ArrestinDb

Beta-arrestin-2 - BB₁ receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
BB₁	73.5
Beta-arrestin-2	81.5

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.7

iPTM Score: 0.6

PAE mean: 15.2

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	TM6	H	253	6x22	S6	R	77	N.S6.02
Hydrophobic	TM6	R	261	6x30	S6	F	76	N.S6.01
Hydrophobic	TM3	D	140	3x49	s5s6	R	66	N.s5s6.02
Hydrophobic	ICL2	M	149	34x51	S9	C	141	N.S9.01
Hydrophobic	ICL2	Q	152	34x54	s5s6	R	66	N.s5s6.02
Hydrophobic	TM6	Q	257	6x26	S6	R	77	N.S6.02
Hydrophobic	ICL3	P	247	-	s15s16	F	245	C.s15s16.03
Hydrophobic	TM6	L	264	6x33	s5s6	L	74	N.s5s6.10
Hydrophobic	TM3	A	144	3x53	s5s6	L	69	N.s5s6.05
Hydrophobic	TM7	L	324	7x53	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	P	148	34x50	s5s6	G	65	N.s5s6.01
Hydrophobic	ICL1	A	73	12x49	s20c	Y	404	C.s20c.14
Hydrophobic	ICL2	M	151	34x53	S16	Y	250	C.S16.03
Hydrophobic	TM3	I	145	3x54	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	M	149	34x51	S15	I	242	C.S15.14
Hydrophobic	TM5	L	239	5x65	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL3	P	247	-	S6	K	78	N.S6.03
Hydrophobic	TM2	S	76	2x37	s5s6	D	68	N.s5s6.04
Hydrophobic	TM3	R	141	3x50	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	M	149	34x51	S16	Y	250	C.S16.03
Hydrophobic	C-term	R	349	-	s20c	C	409	C.s20c.19
Hydrophobic	TM6	L	264	6x33	s5s6	L	72	N.s5s6.08
Hydrophobic	TM2	P	78	2x39	s5s6	V	71	N.s5s6.07
Hydrophobic	C-term	L	365	-	S20	F	388	C.S20.03
Hydrophobic	ICL2	T	153	34x55	s17s18	R	286	C.s17s18.11
Hydrophobic	TM3	I	145	3x54	s5s6	L	69	N.s5s6.05
Hydrophobic	TM3	I	145	3x54	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL2	M	151	34x53	S8	L	130	N.S8.03
Hydrophobic	H8	S	328	8x47	s5s6	V	71	N.s5s6.07
Hydrophobic	TM2	N	79	2x40	s5s6	V	71	N.s5s6.07
Hydrophobic	TM6	R	261	6x30	s5s6	L	74	N.s5s6.10
Hydrophobic	TM3	R	141	3x50	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	M	149	34x51	s15s16	S	246	C.s15s16.04
Hydrophobic	TM2	I	82	2x43	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	M	151	34x53	s8s9	Q	131	N.s8s9.01
Hydrophobic	ICL2	M	151	34x53	s8s9	P	132	N.s8s9.02
Hydrophobic	C-term	M	362	-	ns1	R	8	N.ns1.15
Hydrophobic	TM6	H	253	6x22	S6	D	79	N.S6.04
Hydrophobic	ICL2	S	154	34x56	s8s9	E	135	N.s8s9.05
Hydrophobic	ICL2	P	148	34x50	S5	Y	64	N.S5.12
Hydrophobic	H8	F	331	8x50	s5s6	V	71	N.s5s6.07
Hydrophobic	TM3	A	144	3x53	s5s6	R	66	N.s5s6.02
Hydrophobic	ICL3	G	248	-	S6	K	78	N.S6.03
Hydrophobic	C-term	V	360	-	S20	E	389	C.S20.04
Hydrophobic	TM6	V	268	6x37	s5s6	L	72	N.s5s6.08
Hydrophobic	TM6	H	253	6x22	S6	R	77	N.S6.02
Hydrophobic	C-term	M	362	-	S20	V	387	C.S20.02
Hydrophobic	ICL2	M	149	34x51	S16	A	248	C.S16.01
Hydrophobic	ICL3	L	246	-	s15s16	F	245	C.s15s16.03
Hydrophobic	TM4	L	157	4x39	s8s9	E	135	N.s8s9.05
Hydrophobic	TM2	P	78	2x39	s5s6	D	68	N.s5s6.04
Hydrophobic	TM6	L	264	6x33	s5s6	G	73	N.s5s6.09
Hydrophobic	ICL2	S	154	34x56	s17s18	R	286	C.s17s18.11
Hydrophobic	TM3	I	145	3x54	S6	F	76	N.S6.01
Hydrophobic	C-term	L	365	-	H1	K	108	N.H1.09
Hydrophobic	ICL2	M	151	34x53	s8s9	A	140	N.s8s9.10
Hydrophobic	TM6	N	251	6x20	S6	I	82	N.S6.07
Hydrophobic	H8	S	328	8x47	s5s6	D	70	N.s5s6.06
Hydrophobic	ICL2	M	149	34x51	S5	Y	64	N.S5.12
Hydrophobic	ICL2	M	151	34x53	s17s18	G	287	C.s17s18.12
Hydrophobic	ICL2	Q	152	34x54	s8s9	D	136	N.s8s9.06
Hydrophobic	ICL3	P	247	-	s15s16	L	244	C.s15s16.02
Ionic	TM3	D	140	3x49	s5s6	R	66	N.s5s6.02
Ionic	H8	R	333	8x52	s20c	D	405	C.s20c.15
Ionic	TM6	H	253	6x22	S6	D	79	N.S6.04
Ionic	H8	E	329	8x48	s9s10	K	161	N.s9s10.12
Polar	TM3	D	140	3x49	s5s6	R	66	N.s5s6.02
Polar	H8	R	333	8x52	s20c	D	405	C.s20c.15
Polar	TM6	Q	257	6x26	S6	R	77	N.S6.02
Polar	ICL2	P	148	34x50	s5s6	G	65	N.s5s6.01
Polar	ICL2	Q	152	34x54	s17s18	R	286	C.s17s18.11
Polar	ICL3	P	247	-	S6	K	78	N.S6.03
Polar	H8	H	334	8x53	s20c	Y	404	C.s20c.14
Polar	ICL2	M	149	34x51	S16	Y	250	C.S16.03
Polar	C-term	R	349	-	s20c	C	409	C.s20c.19
Polar	TM1	N	71	1x60	s20c	Y	404	C.s20c.14
Polar	TM6	R	261	6x30	S5	Y	64	N.S5.12
Polar	C-term	S	364	-	s19s20	D	385	C.s19s20.51
Polar	ICL2	T	153	34x55	s17s18	R	286	C.s17s18.11
Polar	TM6	Q	257	6x26	s5s6	S	75	N.s5s6.11
Polar	TM6	H	253	6x22	S6	D	79	N.S6.04
Polar	TM6	R	261	6x30	s5s6	S	75	N.s5s6.11
Polar	C-term	T	363	-	S1	K	11	N.S1.03
Polar	TM4	A	156	4x38	s8s9	E	135	N.s8s9.05
Polar	C-term	T	363	-	S20	F	388	C.S20.03
Polar	ICL1	S	72	12x48	s20c	D	402	C.s20c.12
Polar	C-term	S	367	-	s19s20	D	383	C.s19s20.49
Polar	TM4	L	157	4x39	s8s9	E	135	N.s8s9.05
Polar	ICL2	S	154	34x56	s17s18	R	286	C.s17s18.11
Polar	H8	E	329	8x48	s9s10	K	161	N.s9s10.12
Polar	C-term	L	365	-	H1	K	108	N.H1.09
Polar	H8	S	328	8x47	s5s6	D	70	N.s5s6.06
Polar	ICL2	Q	152	34x54	s5s6	D	68	N.s5s6.04
Van-der-waals	C-term	R	361	-	S20	F	388	C.S20.03
Van-der-waals	TM6	R	261	6x30	S6	F	76	N.S6.01
Van-der-waals	TM3	D	140	3x49	s5s6	R	66	N.s5s6.02
Van-der-waals	ICL2	M	149	34x51	S9	C	141	N.S9.01
Van-der-waals	ICL2	Q	152	34x54	s5s6	R	66	N.s5s6.02
Van-der-waals	TM6	Q	257	6x26	S6	R	77	N.S6.02
Van-der-waals	ICL3	P	247	-	s15s16	F	245	C.s15s16.03
Van-der-waals	TM3	A	144	3x53	s5s6	L	69	N.s5s6.05
Van-der-waals	ICL2	P	148	34x50	s5s6	G	65	N.s5s6.01
Van-der-waals	ICL2	M	151	34x53	S16	Y	250	C.S16.03
Van-der-waals	TM3	I	145	3x54	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL2	M	149	34x51	S15	I	242	C.S15.14
Van-der-waals	TM5	L	239	5x65	s5s6	L	74	N.s5s6.10
Van-der-waals	ICL2	Q	152	34x54	s17s18	R	286	C.s17s18.11
Van-der-waals	ICL3	P	247	-	S6	K	78	N.S6.03
Van-der-waals	TM3	R	141	3x50	s5s6	V	71	N.s5s6.07
Van-der-waals	ICL2	M	149	34x51	S16	Y	250	C.S16.03
Van-der-waals	C-term	R	349	-	s20c	C	409	C.s20c.19
Van-der-waals	TM1	N	71	1x60	s20c	Y	404	C.s20c.14
Van-der-waals	TM6	L	264	6x33	s5s6	L	72	N.s5s6.08
Van-der-waals	C-term	L	365	-	S20	F	388	C.S20.03
Van-der-waals	ICL2	T	153	34x55	s17s18	R	286	C.s17s18.11
Van-der-waals	TM3	I	145	3x54	s5s6	L	69	N.s5s6.05
Van-der-waals	ICL2	M	151	34x53	S8	L	130	N.S8.03
Van-der-waals	TM2	N	79	2x40	s5s6	V	71	N.s5s6.07
Van-der-waals	TM6	Q	257	6x26	s5s6	S	75	N.s5s6.11
Van-der-waals	TM3	R	141	3x50	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL2	M	149	34x51	s15s16	S	246	C.s15s16.04
Van-der-waals	TM2	I	82	2x43	s5s6	V	71	N.s5s6.07
Van-der-waals	ICL2	M	151	34x53	s8s9	Q	131	N.s8s9.01
Van-der-waals	TM6	H	253	6x22	S6	D	79	N.S6.04
Van-der-waals	ICL2	S	154	34x56	s8s9	E	135	N.s8s9.05
Van-der-waals	ICL2	P	148	34x50	S5	Y	64	N.S5.12
Van-der-waals	TM4	A	156	4x38	s8s9	E	135	N.s8s9.05
Van-der-waals	C-term	T	363	-	S20	F	388	C.S20.03
Van-der-waals	TM3	A	144	3x53	s5s6	R	66	N.s5s6.02
Van-der-waals	ICL1	S	72	12x48	s20c	D	402	C.s20c.12
Van-der-waals	ICL3	G	248	-	S6	K	78	N.S6.03
Van-der-waals	C-term	V	360	-	S20	E	389	C.S20.04
Van-der-waals	C-term	M	362	-	S20	V	387	C.S20.02
Van-der-waals	TM4	L	157	4x39	s8s9	E	135	N.s8s9.05
Van-der-waals	TM2	P	78	2x39	s5s6	D	68	N.s5s6.04
Van-der-waals	TM6	L	264	6x33	s5s6	G	73	N.s5s6.09
Van-der-waals	ICL2	S	154	34x56	s17s18	R	286	C.s17s18.11
Van-der-waals	H8	E	329	8x48	s9s10	K	161	N.s9s10.12
Van-der-waals	C-term	L	365	-	H1	K	108	N.H1.09
Van-der-waals	H8	S	328	8x47	s5s6	D	70	N.s5s6.06
Van-der-waals	ICL2	M	151	34x53	s17s18	G	287	C.s17s18.12
Van-der-waals	ICL2	Q	152	34x54	s8s9	D	136	N.s8s9.06
Van-der-waals	H8	R	333	8x52	s9s10	K	161	N.s9s10.12

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Beta-arrestin-2 - BB1 receptor complex model Download Full