Beta-arrestin-2 - BB1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
BB1 73.5
Beta-arrestin-2 81.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals C-term R 361 - S20 F 388 C.S20.03
Hydrophobic TM6 R 261 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 R 261 6x30 S6 F 76 N.S6.01
Ionic TM3 D 140 3x49 s5s6 R 66 N.s5s6.02
Polar TM3 D 140 3x49 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 D 140 3x49 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 D 140 3x49 s5s6 R 66 N.s5s6.02
Ionic H8 R 333 8x52 s20c D 405 C.s20c.15
Polar H8 R 333 8x52 s20c D 405 C.s20c.15
Hydrophobic ICL2 M 149 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 M 149 34x51 S9 C 141 N.S9.01
Hydrophobic ICL2 Q 152 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 152 34x54 s5s6 R 66 N.s5s6.02
Polar TM6 Q 257 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 Q 257 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 Q 257 6x26 S6 R 77 N.S6.02
Hydrophobic ICL3 P 247 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 P 247 - s15s16 F 245 C.s15s16.03
Hydrophobic TM6 L 264 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 A 144 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 144 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM7 L 324 7x53 s5s6 V 71 N.s5s6.07
Polar ICL2 P 148 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic ICL2 P 148 34x50 s5s6 G 65 N.s5s6.01
Van-der-waals ICL2 P 148 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic ICL1 A 73 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL2 M 151 34x53 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 151 34x53 S16 Y 250 C.S16.03
Hydrophobic TM3 I 145 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 145 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 M 149 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 M 149 34x51 S15 I 242 C.S15.14
Hydrophobic TM5 L 239 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 239 5x65 s5s6 L 74 N.s5s6.10
Polar ICL2 Q 152 34x54 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 Q 152 34x54 s17s18 R 286 C.s17s18.11
Polar ICL3 P 247 - S6 K 78 N.S6.03
Hydrophobic ICL3 P 247 - S6 K 78 N.S6.03
Van-der-waals ICL3 P 247 - S6 K 78 N.S6.03
Hydrophobic TM2 S 76 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 141 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 141 3x50 s5s6 V 71 N.s5s6.07
Polar H8 H 334 8x53 s20c Y 404 C.s20c.14
Polar ICL2 M 149 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 M 149 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 149 34x51 S16 Y 250 C.S16.03
Polar C-term R 349 - s20c C 409 C.s20c.19
Hydrophobic C-term R 349 - s20c C 409 C.s20c.19
Van-der-waals C-term R 349 - s20c C 409 C.s20c.19
Polar TM1 N 71 1x60 s20c Y 404 C.s20c.14
Van-der-waals TM1 N 71 1x60 s20c Y 404 C.s20c.14
Hydrophobic TM6 L 264 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 264 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 P 78 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic C-term L 365 - S20 F 388 C.S20.03
Van-der-waals C-term L 365 - S20 F 388 C.S20.03
Polar TM6 R 261 6x30 S5 Y 64 N.S5.12
Polar C-term S 364 - s19s20 D 385 C.s19s20.51
Polar ICL2 T 153 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 T 153 34x55 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 T 153 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic TM3 I 145 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 145 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 I 145 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 M 151 34x53 S8 L 130 N.S8.03
Van-der-waals ICL2 M 151 34x53 S8 L 130 N.S8.03
Hydrophobic H8 S 328 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 N 79 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 N 79 2x40 s5s6 V 71 N.s5s6.07
Polar TM6 Q 257 6x26 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 Q 257 6x26 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 R 261 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 141 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 141 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 M 149 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 M 149 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 I 82 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 I 82 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 M 151 34x53 s8s9 Q 131 N.s8s9.01
Van-der-waals ICL2 M 151 34x53 s8s9 Q 131 N.s8s9.01
Hydrophobic ICL2 M 151 34x53 s8s9 P 132 N.s8s9.02
Hydrophobic C-term M 362 - ns1 R 8 N.ns1.15
Ionic TM6 H 253 6x22 S6 D 79 N.S6.04
Polar TM6 H 253 6x22 S6 D 79 N.S6.04
Hydrophobic TM6 H 253 6x22 S6 D 79 N.S6.04
Van-der-waals TM6 H 253 6x22 S6 D 79 N.S6.04
Hydrophobic ICL2 S 154 34x56 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 S 154 34x56 s8s9 E 135 N.s8s9.05
Polar TM6 R 261 6x30 s5s6 S 75 N.s5s6.11
Hydrophobic ICL2 P 148 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 148 34x50 S5 Y 64 N.S5.12
Polar C-term T 363 - S1 K 11 N.S1.03
Hydrophobic H8 F 331 8x50 s5s6 V 71 N.s5s6.07
Polar TM4 A 156 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 A 156 4x38 s8s9 E 135 N.s8s9.05
Polar C-term T 363 - S20 F 388 C.S20.03
Van-der-waals C-term T 363 - S20 F 388 C.S20.03
Hydrophobic TM3 A 144 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 A 144 3x53 s5s6 R 66 N.s5s6.02
Polar ICL1 S 72 12x48 s20c D 402 C.s20c.12
Van-der-waals ICL1 S 72 12x48 s20c D 402 C.s20c.12
Hydrophobic ICL3 G 248 - S6 K 78 N.S6.03
Van-der-waals ICL3 G 248 - S6 K 78 N.S6.03
Hydrophobic C-term V 360 - S20 E 389 C.S20.04
Van-der-waals C-term V 360 - S20 E 389 C.S20.04
Hydrophobic TM6 V 268 6x37 s5s6 L 72 N.s5s6.08
Aromatic TM6 H 253 6x22 S6 R 77 N.S6.02
Hydrophobic TM6 H 253 6x22 S6 R 77 N.S6.02
Hydrophobic C-term M 362 - S20 V 387 C.S20.02
Van-der-waals C-term M 362 - S20 V 387 C.S20.02
Hydrophobic ICL2 M 149 34x51 S16 A 248 C.S16.01
Hydrophobic ICL3 L 246 - s15s16 F 245 C.s15s16.03
Polar C-term S 367 - s19s20 D 383 C.s19s20.49
Polar TM4 L 157 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 L 157 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 L 157 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 P 78 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 P 78 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 L 264 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 L 264 6x33 s5s6 G 73 N.s5s6.09
Polar ICL2 S 154 34x56 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 S 154 34x56 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 S 154 34x56 s17s18 R 286 C.s17s18.11
Hydrophobic TM3 I 145 3x54 S6 F 76 N.S6.01
Ionic H8 E 329 8x48 s9s10 K 161 N.s9s10.12
Polar H8 E 329 8x48 s9s10 K 161 N.s9s10.12
Van-der-waals H8 E 329 8x48 s9s10 K 161 N.s9s10.12
Polar C-term L 365 - H1 K 108 N.H1.09
Hydrophobic C-term L 365 - H1 K 108 N.H1.09
Van-der-waals C-term L 365 - H1 K 108 N.H1.09
Hydrophobic ICL2 M 151 34x53 s8s9 A 140 N.s8s9.10
Hydrophobic TM6 N 251 6x20 S6 I 82 N.S6.07
Polar H8 S 328 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 S 328 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 328 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 M 149 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 151 34x53 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 M 151 34x53 s17s18 G 287 C.s17s18.12
Hydrophobic ICL2 Q 152 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 Q 152 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals H8 R 333 8x52 s9s10 K 161 N.s9s10.12
Polar ICL2 Q 152 34x54 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 P 247 - s15s16 L 244 C.s15s16.02