Beta-arrestin-2 - NMU1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NMU1 76.3
Beta-arrestin-2 81.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 L 167 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 167 34x51 S16 Y 250 C.S16.03
Polar ICL3 R 272 - S6 L 80 N.S6.05
Van-der-waals ICL3 R 272 - S6 L 80 N.S6.05
Polar ICL3 S 279 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 S 279 - s9s10 E 156 N.s9s10.07
Polar TM1 H 88 1x60 s20c Y 404 C.s20c.14
Van-der-waals TM1 H 88 1x60 s20c Y 404 C.s20c.14
Polar ICL3 R 280 - S6 T 84 N.S6.09
Hydrophobic ICL3 R 280 - S6 T 84 N.S6.09
Van-der-waals ICL3 R 280 - S6 T 84 N.S6.09
Hydrophobic ICL3 Y 281 - S6 D 79 N.S6.04
Hydrophobic ICL2 L 167 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 167 34x51 s15s16 S 246 C.s15s16.04
Ionic ICL2 R 170 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 R 170 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 R 170 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 R 170 34x54 s5s6 G 65 N.s5s6.01
Hydrophobic ICL2 R 170 34x54 s5s6 G 65 N.s5s6.01
Van-der-waals ICL2 R 170 34x54 s5s6 G 65 N.s5s6.01
Hydrophobic ICL3 R 280 - S5 T 57 N.S5.05
Van-der-waals ICL3 R 280 - S5 T 57 N.S5.05
Hydrophobic TM5 L 258 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 167 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 167 34x51 S15 I 242 C.S15.14
Hydrophobic ICL1 A 90 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 A 90 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM3 V 163 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 163 3x54 s5s6 L 69 N.s5s6.05
Polar TM5 R 257 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 H 288 6x26 S6 R 77 N.S6.02
Hydrophobic ICL2 L 167 34x51 S9 C 141 N.S9.01
Polar ICL3 R 272 - S6 D 79 N.S6.04
Polar ICL3 R 284 - S5 T 59 N.S5.07
Polar TM6 H 288 6x26 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 H 288 6x26 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 H 288 6x26 s5s6 S 75 N.s5s6.11
Hydrophobic ICL2 R 170 34x54 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 R 170 34x54 s8s9 A 140 N.s8s9.10
Hydrophobic ICL3 Y 281 - S6 I 82 N.S6.07
Polar H8 S 360 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 R 284 - S6 R 77 N.S6.02
Van-der-waals ICL3 R 284 - S6 R 77 N.S6.02
Hydrophobic TM3 A 162 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 162 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 R 170 34x54 S9 C 141 N.S9.01
Polar H8 S 360 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 360 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 S 360 8x47 s5s6 V 71 N.s5s6.07
Ionic TM4 R 175 4x39 s8s9 E 135 N.s8s9.05
Polar TM4 R 175 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 R 175 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 R 175 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 E 261 5x68 s15s16 F 245 C.s15s16.03
Ionic ICL3 R 284 - S9 E 146 N.S9.06
Hydrophobic TM3 R 159 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 M 298 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 298 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 295 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 295 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 163 3x54 s5s6 L 72 N.s5s6.08
Polar ICL2 R 170 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 170 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 170 34x54 s5s6 R 66 N.s5s6.02
Ionic H8 R 362 8x49 s5s6 E 67 N.s5s6.03
Polar H8 R 362 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 R 362 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 R 362 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 R 292 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 166 34x50 s5s6 G 65 N.s5s6.01
Van-der-waals TM2 T 93 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 L 99 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 163 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 L 167 34x51 S16 A 248 C.S16.01
Ionic TM5 E 268 5x75 S6 K 78 N.S6.03
Polar TM5 E 268 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 E 268 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 E 268 5x75 S6 K 78 N.S6.03
Hydrophobic TM3 V 163 3x54 s5s6 L 74 N.s5s6.10
Polar ICL3 R 280 - s9s10 L 155 N.s9s10.03
Hydrophobic ICL3 R 280 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 R 280 - s9s10 L 155 N.s9s10.03
Hydrophobic ICL2 P 166 34x50 S5 Y 64 N.S5.12
Polar ICL2 R 170 34x54 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 R 170 34x54 s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 R 170 34x54 s8s9 K 139 N.s8s9.09
Polar ICL2 V 173 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 V 173 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 V 173 34x57 s5s6 R 66 N.s5s6.02
Ionic ICL3 R 284 - S6 D 79 N.S6.04
Polar ICL3 R 284 - S6 D 79 N.S6.04
Hydrophobic ICL3 R 284 - S6 D 79 N.S6.04
Van-der-waals ICL3 R 284 - S6 D 79 N.S6.04
Hydrophobic TM6 V 295 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 295 6x33 s5s6 L 72 N.s5s6.08
Polar TM2 T 95 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 95 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 95 2x39 s5s6 D 68 N.s5s6.04
Polar ICL2 A 169 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 169 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 169 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 R 280 - S9 F 150 N.S9.10
Van-der-waals ICL3 R 280 - S9 F 150 N.S9.10