S-arrestin - NMU1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NMU1 75.7
S-arrestin 81.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 Q 287 6x25 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 Q 287 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 L 167 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 167 34x51 S15 V 251 C.S15.14
Hydrophobic TM5 L 265 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 L 265 5x72 S6 R 85 N.S6.03
Hydrophobic TM6 H 288 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 L 299 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals ICL2 L 167 34x51 s15s16 S 255 C.s15s16.04
Polar ICL2 R 170 34x54 S8 L 136 N.S8.03
Hydrophobic ICL2 R 170 34x54 S8 L 136 N.S8.03
Van-der-waals ICL2 R 170 34x54 S8 L 136 N.S8.03
Ionic TM5 E 268 5x75 S6 R 85 N.S6.03
Polar TM5 E 268 5x75 S6 R 85 N.S6.03
Hydrophobic TM5 E 268 5x75 S6 R 85 N.S6.03
Van-der-waals TM5 E 268 5x75 S6 R 85 N.S6.03
Ionic ICL3 R 284 - s9s10 E 165 N.s9s10.07
Polar ICL3 R 284 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 R 284 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 R 284 - s9s10 E 165 N.s9s10.07
Ionic TM6 R 290 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 290 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 290 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic ICL3 R 284 - S6 F 89 N.S6.07
Van-der-waals ICL3 R 284 - S6 F 89 N.S6.07
Polar ICL3 R 284 - S5 T 66 N.S5.07
Hydrophobic ICL3 R 284 - S5 T 66 N.S5.07
Van-der-waals ICL3 R 284 - S5 T 66 N.S5.07
Hydrophobic TM6 V 295 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 295 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 T 93 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 T 93 2x37 s5s6 D 75 N.s5s6.04
Polar ICL3 Y 281 - S6 L 87 N.S6.05
Hydrophobic ICL3 Y 281 - S6 L 87 N.S6.05
Van-der-waals ICL3 Y 281 - S6 L 87 N.S6.05
Polar ICL2 L 167 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 167 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 170 34x54 S9 C 147 N.S9.01
Van-der-waals ICL2 R 170 34x54 S9 C 147 N.S9.01
Hydrophobic ICL2 R 170 34x54 s8s9 S 146 N.s8s9.10
Hydrophobic TM2 N 96 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 96 2x40 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 L 167 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 167 34x51 S16 D 257 C.S16.01
Polar ICL3 R 280 - S6 R 91 N.S6.09
Hydrophobic ICL3 R 280 - S6 R 91 N.S6.09
Van-der-waals ICL3 R 280 - S6 R 91 N.S6.09
Hydrophobic ICL2 R 170 34x54 s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 R 170 34x54 s8s9 P 138 N.s8s9.02
Hydrophobic TM2 L 99 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 L 99 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 L 167 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 L 167 34x51 S9 C 147 N.S9.01
Polar TM5 E 261 5x68 S5 Y 71 N.S5.12
Polar TM6 Q 287 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 Q 287 6x25 s9s10 E 165 N.s9s10.07
Polar ICL2 Q 168 34x52 S16 D 257 C.S16.01
Van-der-waals ICL3 R 284 - S6 R 84 N.S6.02
Polar TM6 H 288 6x26 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 H 288 6x26 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 H 288 6x26 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 V 295 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 295 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM7 Y 356 7x53 s5s6 V 78 N.s5s6.07
Polar H8 S 360 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 S 360 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 360 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 T 95 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 95 2x39 s5s6 V 78 N.s5s6.07
Ionic H8 R 362 8x49 s5s6 D 77 N.s5s6.06
Polar TM5 R 257 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 257 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL3 Y 281 - S6 D 86 N.S6.04
Hydrophobic ICL3 Y 281 - S6 D 86 N.S6.04
Van-der-waals ICL3 Y 281 - S6 D 86 N.S6.04
Hydrophobic TM3 V 163 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 R 159 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 159 3x50 s5s6 I 79 N.s5s6.08
Ionic ICL3 R 284 - S6 D 86 N.S6.04
Polar ICL3 R 284 - S6 D 86 N.S6.04
Hydrophobic ICL3 R 284 - S6 D 86 N.S6.04
Van-der-waals ICL3 R 284 - S6 D 86 N.S6.04
Polar TM6 R 292 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic H8 S 360 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 V 163 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 Q 287 6x25 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 Q 287 6x25 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 292 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 167 34x51 S5 Y 71 N.S5.12
Hydrophobic TM3 A 162 3x53 S6 F 83 N.S6.01
Polar ICL2 R 170 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 170 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 170 34x54 s8s9 K 145 N.s8s9.09
Polar ICL3 R 272 - s7s8 Y 129 N.s7s8.05
Hydrophobic ICL3 R 272 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 R 272 - s7s8 Y 129 N.s7s8.05
Polar ICL2 R 170 34x54 s8s9 Q 137 N.s8s9.01
Hydrophobic ICL2 R 170 34x54 s8s9 Q 137 N.s8s9.01
Van-der-waals ICL2 R 170 34x54 s8s9 Q 137 N.s8s9.01
Hydrophobic ICL3 Y 281 - S6 F 89 N.S6.07
Hydrophobic ICL2 P 166 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 166 34x50 S5 Y 71 N.S5.12
Ionic H8 R 362 8x49 s5s6 D 75 N.s5s6.04
Polar H8 R 362 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 R 362 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic ICL3 Y 281 - S6 Y 88 N.S6.06
Hydrophobic ICL3 R 280 - S6 F 89 N.S6.07
Polar TM2 T 95 2x39 s5s6 D 75 N.s5s6.04
Polar ICL2 V 173 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 173 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 E 261 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 E 261 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 L 258 5x65 s5s6 L 81 N.s5s6.10
Polar ICL3 R 272 - S6 L 87 N.S6.05
Van-der-waals ICL3 R 272 - S6 L 87 N.S6.05
Polar TM7 M 359 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 A 162 3x53 s5s6 I 76 N.s5s6.05
Polar TM3 R 159 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 159 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 159 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 V 163 3x54 S6 F 83 N.S6.01