Beta-arrestin-1 - NMU2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NMU2 76.6
Beta-arrestin-1 82.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 H 150 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 H 150 3x56 s15s16 N 245 C.s15s16.04
Polar TM6 V 266 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 V 266 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 266 6x33 s5s6 L 71 N.s5s6.08
Ionic TM3 E 143 3x49 s5s6 R 65 N.s5s6.02
Polar TM3 E 143 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 E 143 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 156 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 156 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 P 151 34x50 s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 P 151 34x50 s5s6 G 64 N.s5s6.01
Hydrophobic TM4 T 159 4x38 s17s18 R 285 C.s17s18.11
Van-der-waals TM4 T 159 4x38 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 L 156 34x55 s17s18 G 286 C.s17s18.12
Van-der-waals ICL2 L 156 34x55 s17s18 G 286 C.s17s18.12
Hydrophobic TM3 I 148 3x54 S6 F 75 N.S6.01
Polar ICL1 M 76 12x50 s20c E 404 C.s20c.14
Hydrophobic ICL1 M 76 12x50 s20c E 404 C.s20c.14
Van-der-waals ICL1 M 76 12x50 s20c E 404 C.s20c.14
Hydrophobic TM3 I 148 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 148 3x54 s5s6 L 73 N.s5s6.10
Polar TM6 C 262 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 C 262 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 L 270 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 A 147 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 A 147 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 A 147 3x53 s5s6 R 65 N.s5s6.02
Polar H8 S 331 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 331 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 331 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 F 152 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 F 152 34x51 S9 C 140 N.S9.01
Polar ICL2 K 155 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 K 155 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 K 155 34x54 s8s9 K 138 N.s8s9.09
Polar TM6 R 260 6x27 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 260 6x27 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 L 156 34x55 S8 L 129 N.S8.03
Polar H8 R 332 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 R 332 8x48 s5s6 D 69 N.s5s6.06
Polar TM2 T 78 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 T 78 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 T 78 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 L 243 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 243 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 148 3x54 s5s6 L 68 N.s5s6.05
Polar ICL2 K 155 34x54 s8s9 A 139 N.s8s9.10
Hydrophobic ICL2 K 155 34x54 s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 K 155 34x54 s8s9 A 139 N.s8s9.10
Polar H8 R 333 8x49 s5s6 D 69 N.s5s6.06
Polar ICL1 A 75 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 A 75 12x49 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 A 75 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic TM6 C 262 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic ICL1 A 75 12x49 s20c D 402 C.s20c.12
Hydrophobic TM6 L 273 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 273 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 144 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 R 144 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 144 3x50 s5s6 V 70 N.s5s6.07
Polar TM2 T 80 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 T 80 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 80 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 P 151 34x50 S6 F 75 N.S6.01
Ionic TM4 R 160 4x39 s8s9 E 134 N.s8s9.05
Polar TM4 R 160 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 R 160 4x39 s8s9 E 134 N.s8s9.05
Polar TM2 T 80 2x39 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 T 80 2x39 s5s6 R 65 N.s5s6.02
Polar ICL2 K 155 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 K 155 34x54 s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 K 155 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic H8 R 333 8x49 s8s9 G 137 N.s8s9.08
Hydrophobic TM6 M 269 6x36 s5s6 L 71 N.s5s6.08
Ionic H8 R 333 8x49 s20c E 404 C.s20c.14
Polar H8 R 333 8x49 s20c E 404 C.s20c.14
Hydrophobic H8 R 333 8x49 s20c E 404 C.s20c.14
Van-der-waals H8 R 333 8x49 s20c E 404 C.s20c.14
Hydrophobic TM6 I 258 6x25 S6 D 78 N.S6.04
Polar ICL1 K 77 12x51 s8s9 T 136 N.s8s9.07
Polar TM6 R 260 6x27 S6 R 76 N.S6.02
Hydrophobic TM6 R 260 6x27 S6 R 76 N.S6.02
Van-der-waals TM6 R 260 6x27 S6 R 76 N.S6.02
Polar TM5 R 242 5x64 s15s16 F 244 C.s15s16.03
Ionic TM6 R 260 6x27 S6 D 78 N.S6.04
Polar TM6 R 260 6x27 S6 D 78 N.S6.04
Hydrophobic TM6 R 260 6x27 S6 D 78 N.S6.04
Van-der-waals TM6 R 260 6x27 S6 D 78 N.S6.04
Hydrophobic ICL2 L 156 34x55 s17s18 R 285 C.s17s18.11
Polar H8 N 340 8x56 s20c E 407 C.s20c.17
Van-der-waals H8 N 340 8x56 s20c E 407 C.s20c.17
Hydrophobic ICL2 F 152 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 F 152 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic H8 S 331 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM7 I 326 7x52 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 I 326 7x52 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 F 152 34x51 S16 A 247 C.S16.01
Polar ICL2 R 153 34x52 S16 Y 249 C.S16.03
Ionic ICL3 E 253 - S6 K 77 N.S6.03
Polar ICL3 E 253 - S6 K 77 N.S6.03
Van-der-waals ICL3 E 253 - S6 K 77 N.S6.03
Hydrophobic TM3 I 148 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 144 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 152 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 F 152 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 F 152 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 F 152 34x51 S15 I 241 C.S15.14
Hydrophobic ICL2 F 152 34x51 S5 F 61 N.S5.10
Van-der-waals ICL2 F 152 34x51 S5 F 61 N.S5.10
Hydrophobic TM7 Y 327 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 151 34x50 S5 Y 63 N.S5.12
Hydrophobic TM6 V 266 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 V 266 6x33 s5s6 L 73 N.s5s6.10
Polar TM3 L 149 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 L 149 3x55 s15s16 N 245 C.s15s16.04
Polar ICL2 F 152 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 F 152 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 F 152 34x51 S16 Y 249 C.S16.03
Ionic H8 R 333 8x49 s5s6 E 66 N.s5s6.03
Polar H8 R 333 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 R 333 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM7 L 330 7x56 s5s6 V 70 N.s5s6.07
Polar ICL1 A 75 12x49 s20c E 404 C.s20c.14
Hydrophobic ICL1 A 75 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 A 75 12x49 s20c E 404 C.s20c.14
Hydrophobic ICL2 K 155 34x54 S9 C 140 N.S9.01
Hydrophobic TM6 V 266 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 F 152 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 F 152 34x51 s15s16 L 243 C.s15s16.02