Gq - NMU2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-05-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
NMU2 76.6
Gαq 89.7
Gβ1 93.7
Gγ2 74.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 23.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM6 R 263 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 263 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 263 6x30 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 263 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM3 E 143 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 143 3x49 G.H5 Y 356 G.H5.23
Polar TM3 E 143 3x49 G.H5 Y 356 G.H5.23
Polar ICL2 K 155 34x54 G.h2s4 T 224 G.h2s4.05
Van-der-waals ICL2 K 155 34x54 G.h2s4 T 224 G.h2s4.05
Hydrophobic TM2 L 84 2x43 G.H5 N 357 G.H5.24
Van-der-waals TM2 L 84 2x43 G.H5 N 357 G.H5.24
Polar TM6 Q 259 6x26 G.S6 I 324 G.S6.01
Polar TM3 R 144 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 144 3x50 G.H5 N 357 G.H5.24
Ionic H8 R 332 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 R 332 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic H8 R 332 8x48 G.h4s6 D 321 G.h4s6.12
Van-der-waals H8 R 332 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 L 273 6x40 G.H5 L 358 G.H5.25
Polar TM6 N 257 6x24 G.S6 S 326 G.S6.03
Van-der-waals TM6 N 257 6x24 G.S6 S 326 G.S6.03
Hydrophobic TM3 R 144 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 256 6x23 G.S6 S 326 G.S6.03
Van-der-waals TM6 A 256 6x23 G.S6 S 326 G.S6.03
Van-der-waals TM5 R 242 5x64 G.H5 K 345 G.H5.12
Hydrophobic TM3 I 148 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 K 155 34x54 G.H5 I 348 G.H5.15
Hydrophobic TM5 L 243 5x65 G.H5 L 349 G.H5.16
Hydrophobic ICL2 F 152 34x51 G.S3 F 201 G.S3.03
Polar TM6 N 255 6x22 G.S6 F 328 G.S6.05
Hydrophobic TM6 N 255 6x22 G.S6 F 328 G.S6.05
Van-der-waals TM6 N 255 6x22 G.S6 F 328 G.S6.05
Hydrophobic ICL2 L 156 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 L 156 34x55 G.hns1 R 38 G.hns1.03
Polar TM2 T 80 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 80 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 80 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 F 152 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 F 152 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM6 N 257 6x24 G.H4 L 310 G.H4.12
Hydrophobic ICL2 F 152 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 F 152 34x51 G.H5 I 348 G.H5.15
Polar H8 S 331 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 331 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 331 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 156 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 L 156 34x55 G.hns1 R 37 G.hns1.02
Polar ICL3 G 254 - G.H4 R 306 G.H4.08
Hydrophobic ICL2 P 151 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM5 L 243 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM6 Q 259 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM3 I 148 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 148 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM3 A 147 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 Y 356 G.H5.23
Polar TM2 T 80 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 T 80 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL2 F 152 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 F 152 34x51 G.S1 L 40 G.S1.02
Hydrophobic ICL2 P 151 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 151 34x50 G.H5 I 348 G.H5.15
Polar TM3 A 147 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM6 Q 259 6x26 G.H4 V 314 G.H4.16
Van-der-waals TM6 Q 259 6x26 G.H4 V 314 G.H4.16
Hydrophobic TM6 I 258 6x25 G.S6 Y 325 G.S6.02
Van-der-waals TM6 I 258 6x25 G.S6 Y 325 G.S6.02
Aromatic ICL2 F 152 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 F 152 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 F 152 34x51 G.H5 F 341 G.H5.08
Ionic TM6 R 260 6x27 G.H5 D 346 G.H5.13
Polar TM6 R 260 6x27 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 260 6x27 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 260 6x27 G.H5 D 346 G.H5.13
Hydrophobic TM3 I 148 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 148 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM6 L 270 6x37 G.H5 L 358 G.H5.25
Polar TM7 Y 327 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM7 Y 327 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 327 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM4 T 159 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 T 159 4x38 G.hns1 R 37 G.hns1.02
Polar TM6 R 263 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM6 R 263 6x30 G.H5 Q 350 G.H5.17
Van-der-waals TM6 R 263 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM6 V 266 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 P 261 6x28 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 V 266 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 V 266 6x33 G.H5 V 359 G.H5.26
Polar ICL2 S 158 34x57 G.H5 Y 356 G.H5.23
Hydrophobic TM6 M 269 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 M 269 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 256 6x23 G.S6 H 327 G.S6.04
Hydrophobic TM6 R 260 6x27 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 R 260 6x27 G.h4s6 I 323 G.h4s6.20
Polar H8 S 331 8x47 G.H5 V 359 G.H5.26
Hydrophobic H8 S 331 8x47 G.H5 V 359 G.H5.26
Van-der-waals H8 S 331 8x47 G.H5 V 359 G.H5.26
Hydrophobic TM6 R 263 6x30 G.H5 L 349 G.H5.16
Van-der-waals TM6 R 263 6x30 G.H5 L 349 G.H5.16
Polar ICL2 P 151 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 151 34x50 G.H5 N 352 G.H5.19
Hydrophobic TM6 A 256 6x23 G.H5 F 339 G.H5.06
Van-der-waals TM6 A 256 6x23 G.H5 F 339 G.H5.06
Hydrophobic ICL2 K 155 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 K 155 34x54 G.S1 L 40 G.S1.02
Polar TM3 R 144 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM6 N 255 6x22 G.S6 H 327 G.S6.04
Van-der-waals TM6 N 255 6x22 G.S6 H 327 G.S6.04
Polar TM6 N 255 6x22 G.S6 H 327 G.S6.04
Hydrophobic ICL2 F 152 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 F 152 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM6 V 266 6x33 G.H5 L 353 G.H5.20
Van-der-waals TM6 V 266 6x33 G.H5 L 353 G.H5.20
Van-der-waals TM2 T 78 2x37 G.H5 E 355 G.H5.22
Polar TM2 T 78 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 T 78 2x37 G.H5 E 355 G.H5.22
Hydrophobic H8 F 334 8x50 G.H5 N 357 G.H5.24
Van-der-waals H8 F 334 8x50 G.H5 N 357 G.H5.24
Hydrophobic TM5 D 246 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 D 246 5x68 G.H5 L 349 G.H5.16
Hydrophobic C-term L 393 - H.hbhc S 122 H.hbhc.04
Hydrophobic C-term F 371 - G.H2 R 210 G.H2.01
Polar C-term H 389 - H.hbhc K 120 H.hbhc.02
Van-der-waals C-term H 389 - H.hbhc K 120 H.hbhc.02
Hydrophobic TM6 I 258 6x25 G.H5 F 339 G.H5.06
Polar ICL2 S 158 34x57 G.hns1 R 37 G.hns1.02
Hydrophobic C-term F 365 - G.H3 P 262 G.H3.16
Van-der-waals C-term F 365 - G.H3 P 262 G.H3.16
Polar ICL2 K 155 34x54 G.S1 E 39 G.S1.01
Polar H8 R 332 8x48 G.H5 V 359 G.H5.26
Hydrophobic C-term N 390 - H.hbhc K 120 H.hbhc.02
Polar C-term N 390 - H.hbhc K 120 H.hbhc.02
Van-der-waals C-term N 390 - H.hbhc K 120 H.hbhc.02
Hydrophobic C-term L 366 - G.H2 I 217 G.H2.08
Van-der-waals C-term L 366 - G.H2 I 217 G.H2.08
Hydrophobic TM6 I 258 6x25 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 R 260 6x27 G.H5 Q 350 G.H5.17
Van-der-waals TM6 R 260 6x27 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 P 151 34x50 G.H5 K 345 G.H5.12
Hydrophobic C-term L 393 - H.hbhc K 120 H.hbhc.02
Van-der-waals C-term L 393 - H.hbhc K 120 H.hbhc.02
Polar C-term S 391 - H.hbhc K 120 H.hbhc.02
Hydrophobic C-term S 391 - H.hbhc K 120 H.hbhc.02
Van-der-waals C-term S 391 - H.hbhc K 120 H.hbhc.02
Polar C-term E 376 - G.s4h3 N 244 G.s4h3.13
Van-der-waals C-term E 376 - G.s4h3 N 244 G.s4h3.13
Ionic TM5 D 246 5x68 G.H5 K 345 G.H5.12
Hydrophobic C-term L 374 - G.s4h3 E 245 G.s4h3.14
Van-der-waals C-term L 374 - G.s4h3 E 245 G.s4h3.14
Polar TM6 R 260 6x27 G.S6 Y 325 G.S6.02
Hydrophobic TM6 R 260 6x27 G.S6 Y 325 G.S6.02
Van-der-waals TM6 R 260 6x27 G.S6 Y 325 G.S6.02
Polar C-term C 369 - G.H3 Y 261 G.H3.15
Hydrophobic C-term C 369 - G.H3 Y 261 G.H3.15
Van-der-waals C-term C 369 - G.H3 Y 261 G.H3.15
Polar TM6 N 255 6x22 G.H4 R 306 G.H4.08
Aromatic C-term F 371 - G.H2 R 214 G.H2.05
Hydrophobic C-term F 371 - G.H2 R 214 G.H2.05
Van-der-waals C-term F 371 - G.H2 R 214 G.H2.05
Van-der-waals C-term N 390 - H.HB D 117 H.HB.13
Hydrophobic C-term H 392 - H.hbhc K 120 H.hbhc.02
Van-der-waals TM6 M 269 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM6 M 269 6x36 G.H5 N 357 G.H5.24