Beta-arrestin-2 - NPBW1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
NPBW1 79.4
Beta-arrestin-2 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 R 146 - s15s16 S 246 C.s15s16.04
Hydrophobic TM3 V 138 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 138 3x54 s5s6 L 74 N.s5s6.10
Polar C-term C 324 - s20c L 408 C.s20c.18
Hydrophobic C-term C 324 - s20c L 408 C.s20c.18
Van-der-waals C-term C 324 - s20c L 408 C.s20c.18
Ionic H8 R 316 8x52 s5s6 E 67 N.s5s6.03
Polar H8 R 316 8x52 s5s6 E 67 N.s5s6.03
Van-der-waals H8 R 316 8x52 s5s6 E 67 N.s5s6.03
Hydrophobic H8 R 316 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 R 316 8x52 s20c Y 404 C.s20c.14
Hydrophobic TM6 L 242 6x26 s15s16 F 245 C.s15s16.03
Hydrophobic H8 Q 320 8x56 s20c L 408 C.s20c.18
Van-der-waals H8 Q 320 8x56 s20c L 408 C.s20c.18
Polar ICL2 S 144 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 S 144 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 S 144 - s15s16 F 245 C.s15s16.03
Hydrophobic TM4 T 151 4x38 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 T 70 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 70 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 145 - s15s16 S 246 C.s15s16.04
Polar TM6 A 241 6x25 S6 D 79 N.S6.04
Hydrophobic TM6 A 241 6x25 S6 D 79 N.S6.04
Van-der-waals TM6 A 241 6x25 S6 D 79 N.S6.04
Hydrophobic TM6 A 245 6x29 s5s6 L 74 N.s5s6.10
Polar ICL2 R 145 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 R 145 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 S 144 - s15s16 L 244 C.s15s16.02
Polar ICL2 S 144 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 S 144 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 S 144 - s15s16 S 246 C.s15s16.04
Hydrophobic TM6 L 252 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 252 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic H8 T 323 8x59 s20c C 409 C.s20c.19
Hydrophobic ICL2 T 141 - S5 Y 64 N.S5.12
Polar H8 D 311 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 D 311 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 D 311 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 242 6x26 S6 F 76 N.S6.01
Van-der-waals TM7 Y 307 7x53 s5s6 V 71 N.s5s6.07
Polar C-term C 324 - s20c C 409 C.s20c.19
Hydrophobic C-term C 324 - s20c C 409 C.s20c.19
Van-der-waals C-term C 324 - s20c C 409 C.s20c.19
Van-der-waals ICL3 H 238 - S6 I 82 N.S6.07
Hydrophobic TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Ionic H8 R 316 8x52 s20c D 405 C.s20c.15
Polar H8 R 316 8x52 s20c D 405 C.s20c.15
Hydrophobic H8 R 316 8x52 s20c D 405 C.s20c.15
Van-der-waals H8 R 316 8x52 s20c D 405 C.s20c.15
Polar ICL2 S 144 - s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 S 144 - s15s16 T 247 C.s15s16.05
Hydrophobic TM3 V 137 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 137 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 V 249 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 249 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 T 72 2x39 s5s6 V 71 N.s5s6.07
Ionic ICL1 R 67 12x49 s20c D 402 C.s20c.12
Polar ICL1 R 67 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL1 R 67 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 67 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL2 T 141 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 T 141 - s15s16 F 245 C.s15s16.03
Polar ICL2 R 146 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 R 146 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 146 - s8s9 T 137 N.s8s9.07
Hydrophobic TM6 A 241 6x25 S6 R 77 N.S6.02
Van-der-waals TM6 A 241 6x25 S6 R 77 N.S6.02
Hydrophobic H8 D 311 8x47 s5s6 D 70 N.s5s6.06
Polar H8 Q 320 8x56 s20c D 405 C.s20c.15
Van-der-waals H8 Q 320 8x56 s20c D 405 C.s20c.15
Polar H8 Q 320 8x56 s20c Y 404 C.s20c.14
Van-der-waals H8 Q 320 8x56 s20c Y 404 C.s20c.14
Polar TM6 L 242 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 L 242 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 L 242 6x26 S6 R 77 N.S6.02
Hydrophobic H8 L 321 8x57 s20c L 408 C.s20c.18
Van-der-waals H8 L 321 8x57 s20c L 408 C.s20c.18
Hydrophobic ICL1 P 66 12x48 s20c L 408 C.s20c.18
Van-der-waals ICL1 P 66 12x48 s20c L 408 C.s20c.18
Hydrophobic ICL1 R 67 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 67 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM2 I 76 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 T 141 - S6 F 76 N.S6.01
Van-der-waals ICL2 T 141 - S6 F 76 N.S6.01
Hydrophobic TM6 R 248 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 248 6x32 s5s6 G 73 N.s5s6.09