Arrestin-C - NPBW1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NPBW1 78.1
Arrestin-C 81.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 S 144 - S6 K 73 N.S6.03
Hydrophobic ICL2 R 146 - s15s16 S 242 C.s15s16.04
Polar ICL2 S 144 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 S 144 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 S 144 - s15s16 Y 241 C.s15s16.03
Polar TM6 K 240 6x24 s9s10 P 151 N.s9s10.03
Hydrophobic TM6 K 240 6x24 s9s10 P 151 N.s9s10.03
Van-der-waals TM6 K 240 6x24 s9s10 P 151 N.s9s10.03
Hydrophobic TM3 V 138 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 V 138 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 H 238 - S6 V 77 N.S6.07
Van-der-waals ICL3 H 238 - S6 V 77 N.S6.07
Hydrophobic ICL2 R 145 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 R 145 - s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 V 138 3x54 S6 F 71 N.S6.01
Polar TM6 K 240 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 K 240 6x24 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 K 240 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 V 249 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 V 249 6x33 s5s6 L 69 N.s5s6.10
Polar ICL2 R 146 - s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 R 146 - s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 R 146 - s15s16 L 243 C.s15s16.05
Polar TM6 K 240 6x24 s9s10 E 153 N.s9s10.08
Hydrophobic TM6 K 240 6x24 s9s10 E 153 N.s9s10.08
Van-der-waals TM6 K 240 6x24 s9s10 E 153 N.s9s10.08
Polar ICL3 S 237 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 S 237 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 S 237 - s9s10 E 152 N.s9s10.07
Hydrophobic TM2 T 70 2x37 s5s6 D 63 N.s5s6.04
Polar ICL1 R 67 12x49 s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 R 67 12x49 s5s6 R 61 N.s5s6.02
Hydrophobic TM2 T 72 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 72 2x39 s5s6 V 66 N.s5s6.07
Polar TM6 R 248 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 R 248 6x32 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 R 248 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 V 137 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 L 252 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 252 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic H8 D 311 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 V 137 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 V 137 3x53 S6 F 71 N.S6.01
Polar ICL2 R 146 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 R 146 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 R 146 - s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 A 239 6x23 S6 D 74 N.S6.04
Van-der-waals TM6 A 239 6x23 S6 D 74 N.S6.04
Polar ICL3 H 238 - S6 T 79 N.S6.09
Hydrophobic ICL2 T 141 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 T 141 - s15s16 Y 241 C.s15s16.03
Ionic ICL2 R 146 - S16 D 244 C.S16.01
Polar ICL2 R 146 - S16 D 244 C.S16.01
Hydrophobic ICL2 R 146 - S16 D 244 C.S16.01
Van-der-waals ICL2 R 146 - S16 D 244 C.S16.01
Van-der-waals ICL1 R 67 12x49 s17s18 R 282 C.s17s18.11
Hydrophobic TM6 A 241 6x25 S6 R 72 N.S6.02
Van-der-waals TM6 A 241 6x25 S6 R 72 N.S6.02
Polar H8 D 311 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 D 311 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 D 311 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 T 141 - S6 F 71 N.S6.01
Van-der-waals ICL2 T 141 - S6 F 71 N.S6.01
Hydrophobic TM6 A 245 6x29 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 R 134 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 134 3x50 s5s6 I 67 N.s5s6.08