Beta-arrestin-2 - NPBW2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NPBW2 77.2
Beta-arrestin-2 78.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 H 154 - s5s6 R 66 N.s5s6.02
Aromatic ICL2 H 154 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 H 154 - s5s6 R 66 N.s5s6.02
Polar ICL2 V 150 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 V 150 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 V 150 - s15s16 F 245 C.s15s16.03
Hydrophobic TM2 T 78 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 T 78 2x37 s5s6 E 67 N.s5s6.03
Polar ICL2 T 149 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 T 149 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 T 149 - s15s16 S 246 C.s15s16.04
Polar TM2 T 80 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 80 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 80 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 V 258 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 258 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 S 152 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 S 152 - s15s16 S 246 C.s15s16.04
Hydrophobic TM3 R 142 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 142 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 146 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 A 250 6x25 S6 R 77 N.S6.02
Van-der-waals TM6 A 250 6x25 S6 R 77 N.S6.02
Hydrophobic ICL2 H 154 - S16 Y 250 C.S16.03
Polar TM2 T 78 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 78 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic H8 D 320 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 L 244 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 R 245 - s17s18 N 312 C.s17s18.37
Van-der-waals ICL3 R 245 - s17s18 N 312 C.s17s18.37
Hydrophobic TM3 V 145 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 145 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 S 152 - s15s16 F 245 C.s15s16.03
Polar ICL1 K 75 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 75 12x49 s20c D 402 C.s20c.12
Hydrophobic TM6 L 251 6x26 S6 F 76 N.S6.01
Van-der-waals TM6 L 251 6x26 S6 F 76 N.S6.01
Hydrophobic TM6 L 251 6x26 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 L 251 6x26 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 V 146 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 T 149 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 T 149 - s15s16 F 245 C.s15s16.03
Polar ICL2 S 152 - S16 A 248 C.S16.01
Hydrophobic ICL2 S 152 - S16 A 248 C.S16.01
Van-der-waals ICL2 S 152 - S16 A 248 C.S16.01
Polar TM3 R 142 3x50 s5s6 V 71 N.s5s6.07
Polar ICL2 T 149 - S5 Y 64 N.S5.12
Hydrophobic ICL2 T 149 - S5 Y 64 N.S5.12
Van-der-waals ICL2 T 149 - S5 Y 64 N.S5.12
Hydrophobic ICL1 K 75 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 75 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM2 I 84 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 261 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 261 6x36 s5s6 L 72 N.s5s6.08
Polar TM2 V 79 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 V 79 2x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 V 79 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 80 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 A 254 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 L 244 - S6 K 78 N.S6.03
Hydrophobic TM6 K 257 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 257 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 A 250 6x25 S6 D 79 N.S6.04
Hydrophobic TM5 V 242 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 L 239 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 L 239 5x65 S6 F 76 N.S6.01
Polar ICL2 S 152 - s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 S 152 - s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 S 152 - s15s16 T 247 C.s15s16.05
Ionic ICL2 R 158 - s5s6 D 68 N.s5s6.04
Polar ICL2 R 158 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 158 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 158 - s5s6 D 68 N.s5s6.04