Gi1 - NPBW2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-05-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
NPBW2 80.1
Gαi1 89.0
Gβ1 93.4
Gγ2 80.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 S 152 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 S 152 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 S 152 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 154 - G.S3 L 194 G.S3.01
Hydrophobic TM5 V 242 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 242 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 250 6x25 G.H5 K 345 G.H5.17
Van-der-waals TM6 A 250 6x25 G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 156 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 156 - G.hns1 R 32 G.hns1.03
Polar ICL2 P 156 - G.hns1 R 32 G.hns1.03
Hydrophobic TM4 R 161 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 R 161 4x40 G.HN R 24 G.HN.48
Hydrophobic ICL2 H 154 - G.S1 E 33 G.S1.01
Polar ICL2 H 154 - G.S1 E 33 G.S1.01
Hydrophobic ICL2 S 152 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 S 152 - G.S3 L 194 G.S3.01
Polar TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 235 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 S 152 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 M 155 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 M 155 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 S 246 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 S 246 - G.S6 Y 320 G.S6.02
Polar ICL3 S 246 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 R 142 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 142 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 251 6x26 G.H5 I 344 G.H5.16
Van-der-waals TM6 L 251 6x26 G.H5 I 344 G.H5.16
Polar ICL2 H 154 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 154 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 154 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 158 - G.H5 C 351 G.H5.23
Polar ICL2 R 153 - G.H5 N 347 G.H5.19
Hydrophobic TM3 V 146 3x54 G.H5 L 353 G.H5.25
Van-der-waals ICL3 R 245 - G.H5 Q 333 G.H5.05
Hydrophobic ICL3 R 245 - G.H5 Q 333 G.H5.05
Polar TM4 T 159 4x38 G.HN R 24 G.HN.48
Polar ICL3 S 246 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 S 246 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 S 246 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 H 154 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 154 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 154 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 T 149 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 T 149 - G.H5 I 344 G.H5.16
Ionic ICL2 R 158 - G.H5 D 350 G.H5.22
Polar ICL2 R 158 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 158 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 158 - G.H5 D 350 G.H5.22
Polar ICL3 S 246 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 S 246 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 S 246 - G.H5 D 341 G.H5.13
Polar TM2 T 80 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 80 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 251 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 L 251 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 V 258 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 258 6x33 G.H5 L 353 G.H5.25
Polar TM6 V 258 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 261 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 L 261 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 239 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 239 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 251 6x26 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 244 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 244 - G.H5 D 341 G.H5.13
Polar ICL2 T 149 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 T 149 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 T 149 - G.H5 N 347 G.H5.19
Hydrophobic TM3 V 146 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 146 3x54 G.H5 L 348 G.H5.20
Ionic ICL3 R 245 - G.H5 D 337 G.H5.09
Polar ICL3 R 245 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 R 245 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 245 - G.H5 D 337 G.H5.09
Hydrophobic TM6 L 261 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 261 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 145 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 V 145 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 244 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 L 244 - G.H5 I 344 G.H5.16
Polar TM6 K 257 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 257 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 257 6x32 G.H5 F 354 G.H5.26
Aromatic TM6 K 257 6x32 G.H5 F 354 G.H5.26
Polar TM6 A 248 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 248 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 A 248 6x23 G.h4s6 E 318 G.h4s6.12
Polar TM6 A 250 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 A 250 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 250 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 254 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 254 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 145 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 145 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM2 T 80 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 80 2x39 G.H5 C 351 G.H5.23
Ionic ICL2 R 153 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 153 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 153 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 153 - G.s2s3 D 193 G.s2s3.02
Polar ICL3 G 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 G 247 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 G 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 250 6x25 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 250 6x25 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 254 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 153 - G.H5 I 343 G.H5.15
Hydrophobic TM6 K 257 6x32 G.H5 L 353 G.H5.25
Ionic TM6 K 249 6x24 G.h4s6 D 315 G.h4s6.09
Polar TM6 K 249 6x24 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 249 6x24 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 H 154 - G.H5 I 343 G.H5.15
Polar ICL3 R 245 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 245 - G.H5 D 341 G.H5.13
Aromatic TM6 K 253 6x28 G.H5 F 354 G.H5.26
Polar TM6 K 257 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 A 254 6x29 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 262 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 S 152 - G.H5 F 336 G.H5.08
Polar TM3 R 142 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 142 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 142 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 251 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 L 251 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 V 258 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 S 152 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 S 152 - G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL3 S 246 - G.S6 H 322 G.S6.04
Polar TM6 K 253 6x28 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 253 6x28 G.h4s6 D 315 G.h4s6.09
Polar ICL2 H 154 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 H 154 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 H 154 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 153 - G.S3 L 194 G.S3.01
Hydrophobic TM6 A 248 6x23 G.S6 Y 320 G.S6.02
Van-der-waals TM6 A 248 6x23 G.S6 Y 320 G.S6.02
Hydrophobic TM4 T 159 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 159 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 Y 160 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 Y 160 4x39 G.HN R 24 G.HN.48
Aromatic TM4 Y 160 4x39 G.HN R 24 G.HN.48
Ionic ICL1 K 75 12x49 G.h2s4 E 216 G.h2s4.02
Polar ICL1 K 75 12x49 G.h2s4 E 216 G.h2s4.02
Van-der-waals ICL1 K 75 12x49 G.h2s4 E 216 G.h2s4.02
Polar TM4 T 159 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 T 159 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 159 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 A 250 6x25 G.S6 Y 320 G.S6.02
Van-der-waals TM6 A 250 6x25 G.S6 Y 320 G.S6.02
Hydrophobic ICL3 L 244 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 244 - G.H5 K 345 G.H5.17
Polar ICL2 R 158 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 158 - G.hns1 R 32 G.hns1.03
Polar TM4 Y 160 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 Y 160 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 Y 160 4x39 G.HN E 28 G.HN.52
Polar TM6 L 251 6x26 G.h4s6 E 318 G.h4s6.12
Ionic H8 K 325 8x52 G.h3s5 D 261 G.h3s5.02
Polar ICL2 M 155 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 M 155 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 155 - G.hns1 R 32 G.hns1.03
Polar TM6 K 249 6x24 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 249 6x24 G.h4s6 E 318 G.h4s6.12
Polar TM4 R 161 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 156 - G.HN E 28 G.HN.52
Hydrophobic TM6 A 248 6x23 G.H5 K 345 G.H5.17
Hydrophobic ICL2 T 149 - G.H5 I 343 G.H5.15
Van-der-waals ICL3 R 245 - G.H5 F 334 G.H5.06