Beta-arrestin-1 - NPFF1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NPFF1 72.8
Beta-arrestin-1 81.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 E 254 - s9s10 K 157 N.s9s10.09
Van-der-waals ICL3 E 254 - s9s10 K 157 N.s9s10.09
Hydrophobic ICL3 G 253 - S9 K 147 N.S9.08
Van-der-waals ICL3 G 253 - S9 K 147 N.S9.08
Ionic ICL3 E 254 - s9s10 H 159 N.s9s10.11
Polar ICL3 E 254 - s9s10 H 159 N.s9s10.11
Hydrophobic ICL3 E 254 - s9s10 H 159 N.s9s10.11
Van-der-waals ICL3 E 254 - s9s10 H 159 N.s9s10.11
Ionic ICL3 E 255 - S6 R 76 N.S6.02
Hydrophobic TM3 I 145 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 G 252 - s9s10 I 158 N.s9s10.10
Van-der-waals ICL3 G 252 - s9s10 I 158 N.s9s10.10
Polar TM3 C 144 3x53 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 C 144 3x53 s5s6 D 69 N.s5s6.06
Van-der-waals TM3 C 144 3x53 s5s6 D 69 N.s5s6.06
Polar H8 R 338 8x52 s8s9 E 134 N.s8s9.05
Van-der-waals H8 R 338 8x52 s8s9 E 134 N.s8s9.05
Hydrophobic TM3 I 145 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic C-term V 374 - S11 E 185 C.S11.02
Van-der-waals C-term V 374 - S11 E 185 C.S11.02
Hydrophobic ICL2 P 148 - S6 F 75 N.S6.01
Van-der-waals ICL2 P 148 - S6 F 75 N.S6.01
Hydrophobic ICL2 F 149 - S5 F 61 N.S5.10
Hydrophobic TM3 I 145 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic C-term S 379 - s10s11 P 180 C.s10s11.07
Polar C-term V 372 - S11 T 186 C.S11.03
Van-der-waals C-term V 372 - S11 T 186 C.S11.03
Polar ICL3 G 253 - S10 R 165 N.S10.03
Hydrophobic ICL3 G 253 - S10 R 165 N.S10.03
Van-der-waals ICL3 G 253 - S10 R 165 N.S10.03
Polar H8 N 335 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 N 335 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 N 335 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 R 141 3x50 s5s6 L 71 N.s5s6.08
Polar ICL3 G 252 - S9 K 147 N.S9.08
Hydrophobic ICL3 G 252 - S9 K 147 N.S9.08
Van-der-waals ICL3 G 252 - S9 K 147 N.S9.08
Hydrophobic ICL2 R 150 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 R 150 - s15s16 F 244 C.s15s16.03
Polar TM6 R 264 6x29 s5s6 G 72 N.s5s6.09
Ionic ICL3 E 255 - S10 R 165 N.S10.03
Polar ICL3 E 255 - S10 R 165 N.S10.03
Hydrophobic ICL3 E 255 - S10 R 165 N.S10.03
Van-der-waals ICL3 E 255 - S10 R 165 N.S10.03
Hydrophobic TM5 L 243 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 243 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 M 271 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 271 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 V 268 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 268 6x33 s5s6 L 71 N.s5s6.08
Ionic C-term R 371 - S19 D 342 C.S19.02
Polar C-term R 371 - S19 D 342 C.S19.02
Hydrophobic C-term R 371 - S19 D 342 C.S19.02
Van-der-waals C-term R 371 - S19 D 342 C.S19.02
Hydrophobic TM3 C 144 3x53 s5s6 V 70 N.s5s6.07
Polar C-term R 370 - S11 R 188 C.S11.05
Van-der-waals C-term R 370 - S11 R 188 C.S11.05
Van-der-waals C-term S 361 - S16 K 250 C.S16.04
Aromatic C-term Y 360 - S16 Y 249 C.S16.03
Hydrophobic C-term Y 360 - S16 Y 249 C.S16.03
Van-der-waals C-term Y 360 - S16 Y 249 C.S16.03
Hydrophobic C-term F 373 - S19 A 344 C.S19.04
Polar ICL2 K 152 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 K 152 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 K 152 - s15s16 F 244 C.s15s16.03
Polar C-term Y 360 - s8s9 D 135 N.s8s9.06
Van-der-waals C-term Y 360 - s8s9 D 135 N.s8s9.06
Polar TM1 N 71 1x60 s8s9 E 134 N.s8s9.05
Hydrophobic C-term V 374 - S11 T 186 C.S11.03
Hydrophobic ICL2 F 149 - S6 F 75 N.S6.01
Polar C-term R 363 - S16 Q 248 C.S16.02
Hydrophobic C-term R 363 - S16 Q 248 C.S16.02
Van-der-waals C-term R 363 - S16 Q 248 C.S16.02
Polar TM2 T 78 2x39 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 T 78 2x39 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 T 78 2x39 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 F 149 - s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 F 149 - s15s16 L 243 C.s15s16.02
Ionic TM6 R 260 6x25 s20c E 407 C.s20c.17
Polar TM6 R 260 6x25 s20c E 407 C.s20c.17
Hydrophobic TM6 R 260 6x25 s20c E 407 C.s20c.17
Van-der-waals TM6 R 260 6x25 s20c E 407 C.s20c.17
Ionic ICL3 E 255 - S5 R 62 N.S5.11
Polar ICL3 E 255 - S5 R 62 N.S5.11
Hydrophobic TM6 V 268 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 P 251 5x73 s9s10 I 158 N.s9s10.10
Polar ICL3 E 254 - S10 R 165 N.S10.03
Hydrophobic ICL3 E 254 - S10 R 165 N.S10.03
Van-der-waals ICL3 E 254 - S10 R 165 N.S10.03
Hydrophobic C-term F 373 - S18 K 324 C.S18.08
Van-der-waals C-term F 373 - S18 K 324 C.S18.08
Van-der-waals C-term A 359 - S16 K 250 C.S16.04
Hydrophobic ICL2 K 152 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 148 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 148 - s15s16 F 244 C.s15s16.03
Ionic ICL2 K 152 - s5s6 D 69 N.s5s6.06
Polar ICL2 K 152 - s5s6 D 69 N.s5s6.06
Van-der-waals ICL2 K 152 - s5s6 D 69 N.s5s6.06
Polar ICL2 E 151 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 E 151 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 A 256 - s9s10 K 160 N.s9s10.12
Hydrophobic H8 E 334 8x48 s5s6 E 66 N.s5s6.03
Van-der-waals H8 E 334 8x48 s5s6 E 66 N.s5s6.03
Polar ICL3 E 254 - s9s10 I 158 N.s9s10.10
Hydrophobic ICL3 E 254 - s9s10 I 158 N.s9s10.10
Van-der-waals ICL3 E 254 - s9s10 I 158 N.s9s10.10
Hydrophobic H8 N 335 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 N 335 8x49 s5s6 D 67 N.s5s6.04
Polar ICL3 E 254 - s9s10 K 160 N.s9s10.12
Ionic H8 R 338 8x52 s5s6 E 66 N.s5s6.03
Polar TM2 T 76 2x37 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 R 260 6x25 s20c E 404 C.s20c.14
Van-der-waals TM2 T 76 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 F 149 - S6 R 76 N.S6.02
Van-der-waals ICL2 F 149 - S6 R 76 N.S6.02
Polar H8 E 334 8x48 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 I 145 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 145 3x54 S6 F 75 N.S6.01
Polar TM6 R 260 6x25 s20c K 403 C.s20c.13
Van-der-waals TM6 R 260 6x25 s20c K 403 C.s20c.13
Polar ICL2 K 152 - S5 Y 63 N.S5.12
Hydrophobic ICL2 K 152 - S5 Y 63 N.S5.12
Van-der-waals ICL2 K 152 - S5 Y 63 N.S5.12
Polar H8 R 338 8x52 s8s9 T 136 N.s8s9.07
Hydrophobic H8 R 338 8x52 s8s9 T 136 N.s8s9.07
Van-der-waals H8 R 338 8x52 s8s9 T 136 N.s8s9.07
Polar C-term Y 360 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term Y 360 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term Y 360 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term A 359 - S16 C 251 C.S16.05
Hydrophobic C-term F 373 - S19 E 346 C.S19.06
Ionic C-term R 363 - S15 D 240 C.S15.13
Polar C-term R 363 - S15 D 240 C.S15.13
Van-der-waals C-term R 363 - S15 D 240 C.S15.13
Polar ICL3 E 254 - S9 K 147 N.S9.08
Van-der-waals ICL3 E 254 - S9 K 147 N.S9.08
Aromatic ICL2 F 149 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 F 149 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 F 149 - s15s16 F 244 C.s15s16.03
Ionic TM6 R 264 6x29 s20c E 404 C.s20c.14
Polar TM6 R 264 6x29 s20c E 404 C.s20c.14
Van-der-waals TM6 R 264 6x29 s20c E 404 C.s20c.14
Hydrophobic ICL2 F 149 - S6 K 77 N.S6.03
Van-der-waals ICL2 F 149 - S6 K 77 N.S6.03
Hydrophobic C-term V 376 - s10s11 T 183 C.s10s11.10
Van-der-waals C-term V 376 - s10s11 T 183 C.s10s11.10
Hydrophobic TM6 R 265 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic C-term V 376 - S11 A 184 C.S11.01
Van-der-waals C-term V 376 - S11 A 184 C.S11.01