Beta-arrestin-1 - NPFF2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NPFF2 61.3
Beta-arrestin-1 81.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 17.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 253 - S6 F 75 N.S6.01
Hydrophobic TM3 R 245 3x50 s5s6 L 71 N.s5s6.08
Polar TM2 T 180 2x37 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 T 180 2x37 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 T 180 2x37 s5s6 D 69 N.s5s6.06
Polar ICL2 K 256 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 K 256 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 K 256 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 F 253 - S6 K 77 N.S6.03
Van-der-waals ICL2 F 253 - S6 K 77 N.S6.03
Ionic ICL3 R 358 - s9s10 E 155 N.s9s10.07
Polar ICL3 R 358 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 R 358 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 R 358 - s9s10 E 155 N.s9s10.07
Ionic H8 R 444 8x52 s20c E 404 C.s20c.14
Hydrophobic TM6 I 374 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 374 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 K 371 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 F 253 - S5 F 61 N.S5.10
Polar ICL2 P 255 - s15s16 F 244 C.s15s16.03
Hydrophobic TM5 T 356 5x73 s9s10 E 155 N.s9s10.07
Hydrophobic TM2 N 183 2x40 s5s6 L 68 N.s5s6.05
Van-der-waals TM2 N 183 2x40 s5s6 L 68 N.s5s6.05
Polar H8 N 439 8x47 s5s6 L 68 N.s5s6.05
Hydrophobic H8 N 439 8x47 s5s6 L 68 N.s5s6.05
Van-der-waals H8 N 439 8x47 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 F 253 - S6 R 76 N.S6.02
Van-der-waals ICL2 F 253 - S6 R 76 N.S6.02
Hydrophobic TM6 M 377 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 377 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM4 I 259 4x39 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 I 259 4x39 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 V 249 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 249 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 378 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 249 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 P 252 - S6 F 75 N.S6.01
Van-der-waals ICL2 P 252 - S6 F 75 N.S6.01
Hydrophobic TM2 T 180 2x37 s5s6 L 68 N.s5s6.05
Hydrophobic ICL1 M 178 12x50 s5s6 L 68 N.s5s6.05
Van-der-waals ICL1 M 178 12x50 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 P 255 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 255 - s15s16 N 245 C.s15s16.04
Hydrophobic TM3 C 248 3x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 C 248 3x53 s5s6 V 70 N.s5s6.07
Hydrophobic H8 F 442 8x50 s5s6 L 68 N.s5s6.05
Hydrophobic ICL1 K 176 12x48 s8s9 P 133 N.s8s9.04
Van-der-waals ICL1 K 176 12x48 s8s9 P 133 N.s8s9.04
Ionic N-term E 16 - S18 K 326 C.S18.10
Polar N-term E 16 - S18 K 326 C.S18.10
Van-der-waals N-term E 16 - S18 K 326 C.S18.10
Hydrophobic TM3 V 249 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic H8 N 441 8x49 s5s6 L 68 N.s5s6.05
Van-der-waals H8 N 441 8x49 s5s6 L 68 N.s5s6.05
Polar TM2 T 182 2x39 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 T 182 2x39 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 T 182 2x39 s5s6 D 69 N.s5s6.06
Ionic TM6 K 370 6x29 s5s6 E 66 N.s5s6.03
Polar TM6 K 370 6x29 s5s6 E 66 N.s5s6.03
Van-der-waals TM6 K 370 6x29 s5s6 E 66 N.s5s6.03
Ionic TM6 K 370 6x29 s20c E 407 C.s20c.17
Polar TM6 K 370 6x29 s20c E 407 C.s20c.17
Hydrophobic TM6 K 370 6x29 s20c E 407 C.s20c.17
Van-der-waals TM6 K 370 6x29 s20c E 407 C.s20c.17
Polar ICL1 H 177 12x49 s8s9 P 133 N.s8s9.04
Hydrophobic ICL1 H 177 12x49 s8s9 P 133 N.s8s9.04
Van-der-waals ICL1 H 177 12x49 s8s9 P 133 N.s8s9.04
Hydrophobic TM5 L 348 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 348 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic H8 N 441 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 N 441 8x49 s5s6 D 67 N.s5s6.04
Ionic ICL1 K 176 12x48 s8s9 E 134 N.s8s9.05
Polar ICL1 K 176 12x48 s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 K 176 12x48 s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 K 176 12x48 s8s9 E 134 N.s8s9.05
Polar ICL2 K 254 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 K 254 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 K 254 - s15s16 F 244 C.s15s16.03
Aromatic TM6 H 365 6x24 s9s10 K 157 N.s9s10.09
Hydrophobic TM6 H 365 6x24 s9s10 K 157 N.s9s10.09
Van-der-waals TM6 H 365 6x24 s9s10 K 157 N.s9s10.09
Hydrophobic TM6 I 374 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 I 374 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 C 248 3x53 s5s6 D 69 N.s5s6.06
Aromatic ICL2 F 253 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 F 253 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 F 253 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 P 252 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 252 - s15s16 F 244 C.s15s16.03