Gz - NPFF2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-05-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
NPFF2 61.4
Gαz 87.4
Gβ1 94.2
Gγ2 82.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 20.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 370 6x29 G.h4s6 T 317 G.h4s6.10
Hydrophobic TM6 K 370 6x29 G.h4s6 T 317 G.h4s6.10
Van-der-waals TM6 K 370 6x29 G.h4s6 T 317 G.h4s6.10
Hydrophobic ICL2 F 253 - G.H5 F 337 G.H5.08
Van-der-waals ICL2 F 253 - G.H5 F 337 G.H5.08
Hydrophobic TM3 V 249 3x54 G.H5 I 352 G.H5.23
Polar TM2 V 181 2x38 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 P 255 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 H 355 5x72 G.H5 F 335 G.H5.06
Hydrophobic TM5 A 351 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 A 351 5x68 G.H5 D 342 G.H5.13
Hydrophobic ICL2 F 253 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 253 - G.S3 L 195 G.S3.01
Hydrophobic TM3 R 245 3x50 G.H5 I 352 G.H5.23
Polar TM3 C 248 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 C 248 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 C 248 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 M 377 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 377 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 348 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM5 A 351 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 K 256 - G.H5 Y 351 G.H5.22
Van-der-waals ICL2 K 256 - G.H5 Y 351 G.H5.22
Hydrophobic TM3 R 245 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 245 3x50 G.H5 L 354 G.H5.25
Ionic TM6 K 371 6x30 G.H5 D 342 G.H5.13
Polar TM6 K 371 6x30 G.H5 D 342 G.H5.13
Hydrophobic TM6 K 371 6x30 G.H5 D 342 G.H5.13
Van-der-waals TM6 K 371 6x30 G.H5 D 342 G.H5.13
Hydrophobic TM2 T 182 2x39 G.H5 I 352 G.H5.23
Polar TM6 S 368 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 368 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 368 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic H8 E 440 8x48 G.H5 C 355 G.H5.26
Van-der-waals H8 E 440 8x48 G.H5 C 355 G.H5.26
Hydrophobic TM3 V 249 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM3 C 248 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 C 248 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM2 T 180 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM6 I 374 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 I 374 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 348 5x65 G.H5 I 345 G.H5.16
Van-der-waals TM5 L 348 5x65 G.H5 I 345 G.H5.16
Polar TM6 K 370 6x29 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 K 370 6x29 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 K 370 6x29 G.h4s6 E 316 G.h4s6.09
Polar ICL2 P 252 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 252 - G.H5 N 348 G.H5.19
Hydrophobic TM6 I 374 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 374 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 F 253 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 253 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 P 252 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 252 - G.H5 I 344 G.H5.15
Hydrophobic TM6 I 374 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 I 374 6x33 G.H5 C 355 G.H5.26
Hydrophobic TM3 V 249 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 249 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 P 252 - G.H5 I 345 G.H5.16
Polar ICL2 K 256 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 K 256 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 K 256 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 F 253 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 253 - G.H5 T 341 G.H5.12
Polar H8 N 439 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 N 439 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 439 8x47 G.H5 G 353 G.H5.24
Ionic TM5 H 355 5x72 G.H5 D 338 G.H5.09
Hydrophobic TM6 L 378 6x37 G.H5 L 354 G.H5.25
Ionic TM6 K 370 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 370 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 K 370 6x29 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 370 6x29 G.H5 C 355 G.H5.26
Polar N-term Q 53 - G.s4h3 E 237 G.s4h3.10
Polar N-term Q 53 - G.s4h3 D 238 G.s4h3.11
Van-der-waals N-term Q 53 - G.s4h3 D 238 G.s4h3.11
Polar N-term S 51 - G.s4h3 Q 240 G.s4h3.13
Hydrophobic TM5 V 353 5x70 G.H5 A 339 G.H5.10
Hydrophobic ICL2 F 253 - G.S1 I 34 G.S1.02
Hydrophobic TM5 V 353 5x70 G.S6 Y 321 G.S6.02
Van-der-waals TM5 V 353 5x70 G.S6 Y 321 G.S6.02
Hydrophobic TM5 V 353 5x70 G.S6 H 323 G.S6.04
Hydrophobic TM5 V 353 5x70 G.H5 D 338 G.H5.09
Hydrophobic ICL2 P 252 - G.H5 T 341 G.H5.12
Ionic ICL3 R 358 - G.H4 E 298 G.H4.04
Polar ICL3 R 358 - G.H4 E 298 G.H4.04
Hydrophobic ICL3 R 358 - G.H4 E 298 G.H4.04
Van-der-waals ICL3 R 358 - G.H4 E 298 G.H4.04
Polar N-term R 59 - H.HB G 112 H.HB.14
Hydrophobic N-term R 59 - H.HB G 112 H.HB.14
Van-der-waals N-term R 59 - H.HB G 112 H.HB.14
Hydrophobic N-term R 59 - H.hbhc P 113 H.hbhc.01
Van-der-waals N-term R 59 - H.hbhc P 113 H.hbhc.01
Hydrophobic N-term L 63 - H.hbhc K 117 H.hbhc.05
Hydrophobic N-term L 61 - H.hbhc E 115 H.hbhc.03
Hydrophobic N-term L 61 - H.hbhc S 116 H.hbhc.04
Van-der-waals N-term L 61 - H.hbhc S 116 H.hbhc.04
Ionic N-term R 59 - H.hbhc E 115 H.hbhc.03
Polar N-term R 59 - H.hbhc E 115 H.hbhc.03
Hydrophobic N-term L 63 - H.hbhc S 116 H.hbhc.04
Van-der-waals N-term L 63 - H.hbhc S 116 H.hbhc.04