Beta-arrestin-1 - NPS receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NPS 73.2
Beta-arrestin-1 80.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic ICL3 K 255 - s6h1 D 93 N.s6h1.07
Polar ICL3 K 255 - s6h1 D 93 N.s6h1.07
Van-der-waals ICL3 K 255 - s6h1 D 93 N.s6h1.07
Ionic TM6 R 262 6x23 S6 D 78 N.S6.04
Polar TM6 R 262 6x23 S6 D 78 N.S6.04
Van-der-waals TM6 R 262 6x23 S6 D 78 N.S6.04
Polar TM6 A 272 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 272 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 156 34x53 S16 Y 249 C.S16.03
Van-der-waals ICL2 F 156 34x53 S16 Y 249 C.S16.03
Hydrophobic C-term M 362 - s20c R 418 C.s20c.28
Van-der-waals C-term M 362 - s20c R 418 C.s20c.28
Ionic TM3 D 145 3x49 s5s6 R 65 N.s5s6.02
Polar TM3 D 145 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 D 145 3x49 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 D 145 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 P 153 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 153 34x50 S5 Y 63 N.S5.12
Polar TM5 Y 244 5x72 S6 R 76 N.S6.02
Hydrophobic TM5 Y 244 5x72 S6 R 76 N.S6.02
Van-der-waals TM5 Y 244 5x72 S6 R 76 N.S6.02
Polar ICL3 K 255 - s6h1 E 92 N.s6h1.06
Hydrophobic ICL3 K 255 - s6h1 E 92 N.s6h1.06
Van-der-waals ICL3 K 255 - s6h1 E 92 N.s6h1.06
Hydrophobic TM7 F 333 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 F 333 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals ICL3 Y 260 - s9s10 I 158 N.s9s10.10
Hydrophobic ICL2 F 156 34x53 S15 I 241 C.S15.14
Ionic TM2 R 82 2x38 s8s9 D 135 N.s8s9.06
Polar TM2 R 82 2x38 s8s9 D 135 N.s8s9.06
Van-der-waals TM2 R 82 2x38 s8s9 D 135 N.s8s9.06
Hydrophobic TM3 I 150 3x54 S6 F 75 N.S6.01
Hydrophobic ICL3 S 258 - s9s10 L 154 N.s9s10.03
Hydrophobic TM6 Y 275 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 V 247 5x75 S6 D 78 N.S6.04
Van-der-waals TM5 V 247 5x75 S6 D 78 N.S6.04
Hydrophobic ICL2 F 156 34x53 S8 L 129 N.S8.03
Van-der-waals ICL2 F 156 34x53 S8 L 129 N.S8.03
Polar TM2 S 81 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 S 81 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 S 81 2x37 s5s6 D 67 N.s5s6.04
Polar ICL2 P 153 34x50 s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 P 153 34x50 s5s6 G 64 N.s5s6.01
Polar C-term R 359 - s20c R 418 C.s20c.28
Hydrophobic C-term R 359 - s20c R 418 C.s20c.28
Van-der-waals C-term R 359 - s20c R 418 C.s20c.28
Hydrophobic TM2 R 82 2x38 s5s6 R 65 N.s5s6.02
Hydrophobic ICL1 K 78 - s20c K 403 C.s20c.13
Polar ICL3 L 256 - S6 N 83 N.S6.09
Van-der-waals ICL3 L 256 - S6 N 83 N.S6.09
Polar TM2 R 82 2x38 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 82 2x38 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 K 271 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 K 240 5x68 S6 F 75 N.S6.01
Polar ICL3 Y 260 - s9s10 L 154 N.s9s10.03
Hydrophobic ICL3 Y 260 - s9s10 L 154 N.s9s10.03
Van-der-waals ICL3 Y 260 - s9s10 L 154 N.s9s10.03
Van-der-waals TM6 A 268 6x29 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 M 83 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 M 83 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM4 G 159 4x38 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 F 156 34x53 S9 C 140 N.S9.01
Polar TM4 E 160 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 E 160 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 M 154 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 M 154 34x51 S5 Y 63 N.S5.12
Hydrophobic H8 S 334 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 150 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 272 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 272 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 I 237 5x65 s5s6 L 73 N.s5s6.10
Polar C-term E 358 - s20c R 418 C.s20c.28
Hydrophobic C-term E 358 - s20c R 418 C.s20c.28
Van-der-waals C-term E 358 - s20c R 418 C.s20c.28
Polar TM2 M 83 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 M 83 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 M 83 2x39 s5s6 D 67 N.s5s6.04
Ionic ICL1 K 78 - s20c E 407 C.s20c.17
Polar ICL1 K 78 - s20c E 407 C.s20c.17
Van-der-waals ICL1 K 78 - s20c E 407 C.s20c.17
Polar TM5 Y 244 5x72 S5 Y 63 N.S5.12
Van-der-waals TM5 Y 244 5x72 S5 Y 63 N.S5.12
Hydrophobic ICL2 M 154 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 M 154 34x51 S15 I 241 C.S15.14
Hydrophobic TM6 A 268 6x29 s5s6 L 73 N.s5s6.10
Ionic ICL1 K 79 - s20c E 404 C.s20c.14
Polar ICL1 K 79 - s20c E 404 C.s20c.14
Hydrophobic ICL1 K 79 - s20c E 404 C.s20c.14
Van-der-waals ICL1 K 79 - s20c E 404 C.s20c.14
Polar ICL1 K 79 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 K 79 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 K 79 - s8s9 T 136 N.s8s9.07
Polar TM5 Y 244 5x72 S6 K 77 N.S6.03
Hydrophobic TM5 Y 244 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 Y 244 5x72 S6 K 77 N.S6.03
Hydrophobic ICL1 K 79 - s20c D 402 C.s20c.12
Hydrophobic TM5 I 248 5x76 s17s18 I 314 C.s17s18.40
Polar ICL2 M 154 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 M 154 34x51 S16 Y 249 C.S16.03
Hydrophobic TM3 R 146 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 146 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 150 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 157 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 L 157 - S16 Y 249 C.S16.03
Van-der-waals ICL2 L 157 - S16 Y 249 C.S16.03
Hydrophobic TM6 K 269 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 K 269 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 Y 244 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Y 244 5x72 s15s16 F 244 C.s15s16.03
Ionic ICL1 K 79 - s5s6 E 66 N.s5s6.03
Polar ICL1 K 79 - s5s6 E 66 N.s5s6.03
Van-der-waals ICL1 K 79 - s5s6 E 66 N.s5s6.03
Hydrophobic TM3 I 150 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 A 268 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 A 268 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic C-term I 364 - s20c N 417 C.s20c.27
Hydrophobic ICL2 M 154 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 M 154 34x51 s15s16 N 245 C.s15s16.04
Polar ICL3 S 258 - S6 N 83 N.S6.09
Van-der-waals ICL3 S 258 - S6 N 83 N.S6.09
Polar C-term H 360 - s20c R 418 C.s20c.28
Hydrophobic C-term H 360 - s20c R 418 C.s20c.28
Van-der-waals C-term H 360 - s20c R 418 C.s20c.28
Polar TM6 K 271 6x32 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 K 271 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic TM7 Y 330 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 A 149 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 M 154 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 M 154 34x51 S9 C 140 N.S9.01
Hydrophobic TM3 A 149 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 A 149 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 C 251 5x79 S6 F 80 N.S6.06
Polar ICL1 K 80 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 K 80 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 K 80 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 L 256 - s9s10 L 154 N.s9s10.03