S-arrestin - NPS receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NPS 73.2
S-arrestin 80.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 R 82 2x38 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 M 154 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 M 154 34x51 S15 V 251 C.S15.14
Hydrophobic TM6 K 269 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 P 153 34x50 s15s16 Y 254 C.s15s16.03
Polar ICL3 Y 260 - s9s10 A 163 N.s9s10.05
Hydrophobic ICL3 Y 260 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 Y 260 - s9s10 A 163 N.s9s10.05
Hydrophobic C-term T 352 - s4s5 L 55 N.s4s5.04
Van-der-waals C-term T 352 - s4s5 L 55 N.s4s5.04
Hydrophobic ICL2 F 156 34x53 S5 Y 71 N.S5.12
Van-der-waals ICL2 F 156 34x53 S5 Y 71 N.S5.12
Van-der-waals TM7 F 333 7x56 s5s6 V 78 N.s5s6.07
Polar TM6 A 272 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 272 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 272 6x33 s5s6 I 79 N.s5s6.08
Ionic ICL1 K 78 - s20c D 402 C.s20c.21
Polar ICL1 K 78 - s20c D 402 C.s20c.21
Van-der-waals ICL1 K 78 - s20c D 402 C.s20c.21
Polar ICL2 K 155 34x52 s8s9 K 145 N.s8s9.09
Hydrophobic C-term R 354 - S4 L 50 N.S4.06
Van-der-waals C-term R 354 - S4 L 50 N.S4.06
Hydrophobic ICL2 M 154 34x51 S8 L 136 N.S8.03
Hydrophobic C-term R 354 - S1 I 20 N.S1.05
Van-der-waals C-term R 354 - S1 I 20 N.S1.05
Ionic C-term E 361 - H1 K 114 N.H1.09
Hydrophobic C-term E 361 - H1 K 114 N.H1.09
Van-der-waals C-term E 361 - H1 K 114 N.H1.09
Ionic C-term E 358 - S1 K 18 N.S1.03
Polar C-term E 358 - S1 K 18 N.S1.03
Van-der-waals C-term E 358 - S1 K 18 N.S1.03
Polar C-term R 354 - S2 Y 29 N.S2.04
Van-der-waals C-term R 354 - S2 Y 29 N.S2.04
Hydrophobic TM6 A 268 6x29 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 A 268 6x29 s5s6 G 80 N.s5s6.09
Polar H8 S 346 8x59 s9s10 K 171 N.s9s10.13
Hydrophobic C-term E 361 - S20 F 379 C.S20.03
Van-der-waals C-term E 361 - S20 F 379 C.S20.03
Hydrophobic TM2 S 81 2x37 s5s6 Q 73 N.s5s6.02
Ionic TM6 R 262 6x23 s9s10 E 165 N.s9s10.07
Polar TM6 R 262 6x23 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 R 262 6x23 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 262 6x23 s9s10 E 165 N.s9s10.07
Hydrophobic ICL2 F 156 34x53 S16 Y 259 C.S16.03
Van-der-waals ICL2 F 156 34x53 S16 Y 259 C.S16.03
Hydrophobic TM6 R 262 6x23 S6 R 84 N.S6.02
Van-der-waals TM6 R 262 6x23 S6 R 84 N.S6.02
Polar TM5 N 250 5x78 s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 N 250 5x78 s7s8 Y 129 N.s7s8.05
Polar TM2 R 82 2x38 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 M 83 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 M 83 2x39 s5s6 V 78 N.s5s6.07
Polar ICL3 K 255 - s6h1 V 98 N.s6h1.03
Van-der-waals TM5 I 248 5x76 S6 Y 88 N.S6.06
Polar ICL2 M 154 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 M 154 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 M 154 34x51 S5 Y 71 N.S5.12
Polar ICL3 S 258 - S6 R 91 N.S6.09
Van-der-waals ICL3 S 258 - S6 R 91 N.S6.09
Hydrophobic H8 S 334 8x47 s5s6 V 78 N.s5s6.07
Polar TM3 R 146 3x50 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 R 146 3x50 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 R 146 3x50 s5s6 I 76 N.s5s6.05
Hydrophobic C-term L 365 - S20 V 378 C.S20.02
Aromatic ICL3 Y 260 - S6 F 89 N.S6.07
Hydrophobic ICL3 Y 260 - S6 F 89 N.S6.07
Van-der-waals ICL3 Y 260 - S6 F 89 N.S6.07
Hydrophobic TM3 I 150 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 150 3x54 s5s6 L 81 N.s5s6.10
Polar TM5 T 243 5x71 S6 R 85 N.S6.03
Hydrophobic TM2 M 83 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 M 83 2x39 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 V 247 5x75 S6 Y 88 N.S6.06
Hydrophobic TM5 I 237 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 K 240 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 A 268 6x29 s5s6 L 81 N.s5s6.10
Polar H8 E 343 8x56 s20c E 405 C.s20c.24
Hydrophobic H8 E 343 8x56 s20c E 405 C.s20c.24
Van-der-waals H8 E 343 8x56 s20c E 405 C.s20c.24
Hydrophobic ICL2 M 154 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 M 154 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 Y 275 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 Y 275 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 F 156 34x53 S9 C 147 N.S9.01
Hydrophobic TM5 V 247 5x75 S6 L 87 N.S6.05
Polar C-term R 354 - S2 T 27 N.S2.02
Hydrophobic C-term R 354 - S2 T 27 N.S2.02
Van-der-waals C-term R 354 - S2 T 27 N.S2.02
Ionic TM6 R 262 6x23 S6 D 86 N.S6.04
Polar TM6 R 262 6x23 S6 D 86 N.S6.04
Hydrophobic TM6 R 262 6x23 S6 D 86 N.S6.04
Van-der-waals TM6 R 262 6x23 S6 D 86 N.S6.04
Aromatic TM5 Y 244 5x72 S6 R 85 N.S6.03
Hydrophobic TM5 Y 244 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 Y 244 5x72 S6 R 85 N.S6.03
Hydrophobic ICL2 F 156 34x53 S8 L 136 N.S8.03
Polar ICL2 M 154 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 M 154 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 M 154 34x51 S16 Y 259 C.S16.03
Polar TM2 S 81 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 S 81 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 S 81 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 Y 244 5x72 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 Y 244 5x72 s15s16 L 253 C.s15s16.02
Hydrophobic H8 E 343 8x56 s20c D 404 C.s20c.23
Van-der-waals H8 E 343 8x56 s20c D 404 C.s20c.23
Hydrophobic ICL1 K 79 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 K 79 - s5s6 D 75 N.s5s6.04
Ionic ICL1 K 79 - s5s6 E 74 N.s5s6.03
Polar ICL1 K 79 - s5s6 E 74 N.s5s6.03
Van-der-waals ICL1 K 79 - s5s6 E 74 N.s5s6.03
Hydrophobic ICL3 S 258 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 S 258 - s9s10 A 163 N.s9s10.05
Polar TM6 K 271 6x32 s5s6 V 78 N.s5s6.07
Polar ICL2 P 153 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 153 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 153 34x50 S5 Y 71 N.S5.12
Hydrophobic TM5 Y 244 5x72 S6 R 84 N.S6.02
Hydrophobic ICL2 M 154 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 M 154 34x51 S9 C 147 N.S9.01
Hydrophobic TM7 Y 330 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 330 7x53 s5s6 V 78 N.s5s6.07
Polar C-term K 367 - s20c H 385 C.s20c.04
Polar ICL3 Y 260 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 Y 260 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 Y 260 - s9s10 E 165 N.s9s10.07
Polar TM5 Y 244 5x72 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 Y 244 5x72 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 Y 244 5x72 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 V 247 5x75 S6 D 86 N.S6.04
Van-der-waals TM5 V 247 5x75 S6 D 86 N.S6.04
Hydrophobic TM3 I 150 3x54 S6 F 83 N.S6.01
Polar TM5 I 248 5x76 s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 I 248 5x76 s7s8 Y 129 N.s7s8.05
Van-der-waals TM5 I 248 5x76 s7s8 Y 129 N.s7s8.05
Hydrophobic TM6 A 272 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 272 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 N 250 5x78 S6 Y 88 N.S6.06
Hydrophobic TM6 K 271 6x32 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 146 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 146 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 M 154 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 M 154 34x51 S16 D 257 C.S16.01
Hydrophobic C-term L 365 - ns1 N 13 N.ns1.13
Van-der-waals C-term L 365 - ns1 N 13 N.ns1.13
Hydrophobic C-term M 362 - S1 K 18 N.S1.03
Van-der-waals C-term M 362 - S1 K 18 N.S1.03
Polar ICL2 F 156 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 156 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 F 156 34x53 s8s9 K 145 N.s8s9.09
Ionic TM6 K 267 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 K 267 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 K 267 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 267 6x28 s9s10 D 166 N.s9s10.08
Polar TM1 R 77 1x60 s5s6 D 77 N.s5s6.06