Beta-arrestin-1 - Y1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
Y1 70.5
Beta-arrestin-1 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 N 251 6x23 S6 D 78 N.S6.04
Van-der-waals TM6 N 251 6x23 S6 D 78 N.S6.04
Ionic C-term H 356 - s17s18 E 313 C.s17s18.39
Polar ICL2 R 146 - s15s16 C 242 C.s15s16.01
Van-der-waals ICL2 R 146 - s15s16 C 242 C.s15s16.01
Polar C-term S 353 - S6 D 78 N.S6.04
Hydrophobic C-term S 353 - S6 D 78 N.S6.04
Van-der-waals C-term S 353 - S6 D 78 N.S6.04
Hydrophobic TM2 I 79 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 I 79 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 138 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 138 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 145 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 145 - s15s16 F 244 C.s15s16.03
Polar H8 N 326 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 N 326 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 N 326 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic C-term A 351 - s5s6 T 74 N.s5s6.11
Van-der-waals C-term A 351 - s5s6 T 74 N.s5s6.11
Polar C-term D 358 - s17s18 N 311 C.s17s18.37
Hydrophobic C-term D 358 - s17s18 N 311 C.s17s18.37
Van-der-waals C-term D 358 - s17s18 N 311 C.s17s18.37
Hydrophobic TM2 N 73 2x37 s5s6 L 68 N.s5s6.05
Van-der-waals TM2 N 73 2x37 s5s6 L 68 N.s5s6.05
Hydrophobic C-term A 351 - S6 R 76 N.S6.02
Van-der-waals C-term A 351 - S6 R 76 N.S6.02
Polar H8 N 324 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 L 141 3x53 s8s9 K 138 N.s8s9.09
Van-der-waals TM2 N 76 2x40 s5s6 V 70 N.s5s6.07
Polar C-term T 354 - S6 R 76 N.S6.02
Hydrophobic C-term T 354 - S6 R 76 N.S6.02
Van-der-waals C-term T 354 - S6 R 76 N.S6.02
Hydrophobic ICL2 R 149 - s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 R 149 - s8s9 G 137 N.s8s9.08
Polar H8 N 324 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 N 324 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 N 324 8x47 s5s6 V 70 N.s5s6.07
Polar H8 N 326 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 326 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 326 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic C-term M 355 - S6 F 80 N.S6.06
Polar ICL2 R 149 - S5 Y 63 N.S5.12
Hydrophobic ICL2 R 149 - S5 Y 63 N.S5.12
Van-der-waals ICL2 R 149 - S5 Y 63 N.S5.12
Hydrophobic TM2 T 75 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 T 75 2x39 s5s6 V 70 N.s5s6.07
Polar C-term E 348 - S10 S 163 N.S10.01
Hydrophobic C-term E 348 - S10 S 163 N.S10.01
Van-der-waals C-term E 348 - S10 S 163 N.S10.01
Polar ICL2 R 146 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 146 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 146 - s15s16 N 245 C.s15s16.04
Hydrophobic C-term R 343 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term R 343 - s9s10 R 161 N.s9s10.13
Hydrophobic C-term M 355 - S6 K 77 N.S6.03
Van-der-waals C-term M 355 - S6 K 77 N.S6.03
Hydrophobic TM4 N 151 4x38 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 N 151 4x38 s8s9 T 136 N.s8s9.07
Ionic TM6 K 252 6x24 s9s10 E 155 N.s9s10.07
Polar TM6 K 252 6x24 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 K 252 6x24 s9s10 E 155 N.s9s10.07
Hydrophobic TM7 Y 320 7x53 s5s6 V 70 N.s5s6.07
Polar ICL2 R 146 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 R 146 - s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 R 146 - s15s16 T 246 C.s15s16.05
Hydrophobic C-term T 354 - S6 K 77 N.S6.03
Van-der-waals C-term T 354 - S6 K 77 N.S6.03
Ionic ICL2 R 146 - s17s18 E 313 C.s17s18.39
Polar ICL2 R 146 - s17s18 E 313 C.s17s18.39
Van-der-waals ICL2 R 146 - s17s18 E 313 C.s17s18.39
Hydrophobic C-term D 358 - s17s18 I 314 C.s17s18.40
Van-der-waals C-term D 358 - s17s18 I 314 C.s17s18.40
Hydrophobic C-term M 355 - S6 L 79 N.S6.05
Polar TM2 N 73 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 73 2x37 s5s6 D 67 N.s5s6.04
Polar TM3 R 138 3x50 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 R 138 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 M 264 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 264 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic C-term T 354 - s15s16 F 244 C.s15s16.03
Van-der-waals C-term T 354 - s15s16 F 244 C.s15s16.03
Polar ICL3 R 249 - S6 V 81 N.S6.07
Hydrophobic ICL3 R 249 - S6 V 81 N.S6.07
Van-der-waals ICL3 R 249 - S6 V 81 N.S6.07
Hydrophobic TM6 I 261 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 261 6x33 s5s6 L 71 N.s5s6.08
Polar H8 N 324 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 324 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 324 8x47 s5s6 D 69 N.s5s6.06
Polar ICL1 E 70 12x49 s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 E 70 12x49 s5s6 R 65 N.s5s6.02
Polar H8 N 326 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic H8 N 326 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 N 326 8x49 s5s6 D 67 N.s5s6.04
Polar C-term H 356 - S6 K 77 N.S6.03
Hydrophobic C-term H 356 - S6 K 77 N.S6.03
Van-der-waals C-term H 356 - S6 K 77 N.S6.03
Aromatic C-term Y 347 - s9s10 K 157 N.s9s10.09
Hydrophobic C-term Y 347 - s9s10 K 157 N.s9s10.09
Van-der-waals C-term Y 347 - s9s10 K 157 N.s9s10.09
Hydrophobic TM6 I 261 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 I 261 6x33 s5s6 L 73 N.s5s6.10
Ionic C-term D 345 - s9s10 H 159 N.s9s10.11
Polar C-term D 345 - s9s10 H 159 N.s9s10.11
Hydrophobic C-term D 345 - s9s10 H 159 N.s9s10.11
Van-der-waals C-term D 345 - s9s10 H 159 N.s9s10.11
Hydrophobic TM6 L 265 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 265 6x37 s5s6 L 71 N.s5s6.08
Ionic C-term D 346 - s9s10 K 160 N.s9s10.12
Polar C-term D 346 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term D 346 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term D 346 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL1 E 70 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 E 70 12x49 s20c D 402 C.s20c.12
Hydrophobic C-term H 356 - s15s16 L 243 C.s15s16.02
Hydrophobic C-term T 354 - S6 F 75 N.S6.01
Ionic TM6 R 254 6x26 S6 D 78 N.S6.04
Polar TM6 R 254 6x26 S6 D 78 N.S6.04
Hydrophobic TM6 R 254 6x26 S6 D 78 N.S6.04
Van-der-waals TM6 R 254 6x26 S6 D 78 N.S6.04
Hydrophobic ICL1 E 70 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 E 70 12x49 s20c E 404 C.s20c.14
Hydrophobic C-term M 352 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term M 352 - s5s6 L 73 N.s5s6.10
Hydrophobic TM6 Y 253 6x25 s9s10 K 157 N.s9s10.09
Hydrophobic C-term Y 347 - s9s10 K 160 N.s9s10.12
Hydrophobic H8 K 325 8x48 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 R 149 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 149 - s8s9 T 136 N.s8s9.07
Hydrophobic C-term M 355 - S6 D 78 N.S6.04
Van-der-waals C-term M 355 - S6 D 78 N.S6.04
Aromatic TM5 R 241 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 241 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 241 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL1 M 71 12x50 s5s6 D 67 N.s5s6.04
Aromatic C-term Y 347 - s9s10 H 159 N.s9s10.11
Hydrophobic C-term Y 347 - s9s10 H 159 N.s9s10.11
Ionic H8 R 329 8x52 s20c E 407 C.s20c.17
Polar H8 R 329 8x52 s20c E 407 C.s20c.17
Hydrophobic H8 R 329 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 R 329 8x52 s20c E 407 C.s20c.17
Hydrophobic TM3 I 142 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 142 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 142 3x54 S6 F 75 N.S6.01
Hydrophobic TM6 I 261 6x33 s5s6 G 72 N.s5s6.09
Polar C-term M 352 - S6 R 76 N.S6.02
Hydrophobic C-term M 352 - S6 R 76 N.S6.02
Van-der-waals C-term M 352 - S6 R 76 N.S6.02
Polar ICL2 R 146 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 R 146 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 R 146 - s15s16 F 244 C.s15s16.03
Polar ICL2 R 149 - S16 Y 249 C.S16.03
Van-der-waals ICL2 R 149 - S16 Y 249 C.S16.03
Polar ICL3 R 249 - S6 N 83 N.S6.09
Hydrophobic ICL3 R 249 - S6 N 83 N.S6.09
Van-der-waals ICL3 R 249 - S6 N 83 N.S6.09
Polar C-term S 353 - S6 K 77 N.S6.03
Hydrophobic C-term S 353 - S6 K 77 N.S6.03
Van-der-waals C-term S 353 - S6 K 77 N.S6.03
Polar C-term D 346 - s9s10 H 159 N.s9s10.11
Hydrophobic C-term D 346 - s9s10 H 159 N.s9s10.11
Van-der-waals C-term D 346 - s9s10 H 159 N.s9s10.11
Polar C-term E 348 - s9s10 I 158 N.s9s10.10
Hydrophobic C-term M 355 - S6 V 81 N.S6.07
Hydrophobic ICL2 R 149 - S16 A 247 C.S16.01
Van-der-waals ICL2 R 149 - S16 A 247 C.S16.01
Hydrophobic TM6 M 264 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 M 264 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic C-term Y 347 - s9s10 I 158 N.s9s10.10
Van-der-waals C-term Y 347 - s9s10 I 158 N.s9s10.10
Hydrophobic TM3 R 138 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 138 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 P 145 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 145 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 145 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL1 E 70 12x49 s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 E 70 12x49 s5s6 D 67 N.s5s6.04
Hydrophobic C-term S 353 - S6 R 76 N.S6.02
Van-der-waals C-term S 353 - S6 R 76 N.S6.02
Polar ICL2 R 149 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 149 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 149 - s15s16 N 245 C.s15s16.04
Ionic C-term E 348 - S10 R 165 N.S10.03
Polar C-term E 348 - S10 R 165 N.S10.03
Hydrophobic C-term E 348 - S10 R 165 N.S10.03
Van-der-waals C-term E 348 - S10 R 165 N.S10.03
Hydrophobic C-term E 348 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term E 348 - s9s10 K 160 N.s9s10.12
Ionic C-term E 348 - S9 K 147 N.S9.08
Polar C-term E 348 - S9 K 147 N.S9.08
Hydrophobic C-term E 348 - S9 K 147 N.S9.08
Van-der-waals C-term E 348 - S9 K 147 N.S9.08
Polar C-term M 352 - s5s6 T 74 N.s5s6.11
Hydrophobic C-term M 352 - s5s6 T 74 N.s5s6.11
Van-der-waals C-term M 352 - s5s6 T 74 N.s5s6.11
Polar TM6 E 257 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic C-term M 352 - S6 F 75 N.S6.01
Van-der-waals C-term M 352 - S6 F 75 N.S6.01