Arrestin-C - Y2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
Y2 75.3
Arrestin-C 82.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term S 354 - s9s10 T 154 N.s9s10.09
Van-der-waals C-term S 354 - s9s10 T 154 N.s9s10.09
Polar H8 R 345 8x63 s20c G 384 C.s20c.18
Hydrophobic H8 R 345 8x63 s20c G 384 C.s20c.18
Polar TM5 H 249 5x68 s15s16 Y 241 C.s15s16.03
Aromatic TM5 H 249 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 249 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 249 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 156 - S8 L 126 N.S8.03
Hydrophobic TM5 S 251 5x70 S6 F 71 N.S6.01
Polar TM6 R 262 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 R 262 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM3 C 151 3x53 s5s6 L 64 N.s5s6.05
Polar ICL2 E 157 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 E 157 - s5s6 R 61 N.s5s6.02
Polar C-term A 359 - s9s10 E 152 N.s9s10.07
Hydrophobic C-term A 359 - s9s10 E 152 N.s9s10.07
Van-der-waals C-term A 359 - s9s10 E 152 N.s9s10.07
Hydrophobic TM6 Y 259 6x26 s15s16 Y 241 C.s15s16.03
Hydrophobic C-term T 356 - s9s10 T 154 N.s9s10.09
Van-der-waals C-term T 356 - s9s10 T 154 N.s9s10.09
Polar TM5 K 245 5x64 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 K 245 5x64 s15s16 S 242 C.s15s16.04
Polar TM5 V 250 5x69 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 V 250 5x69 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 V 250 5x69 s15s16 Y 241 C.s15s16.03
Ionic TM5 K 245 5x64 S16 D 244 C.S16.01
Polar TM5 K 245 5x64 S16 D 244 C.S16.01
Hydrophobic TM5 K 245 5x64 S16 D 244 C.S16.01
Van-der-waals TM5 K 245 5x64 S16 D 244 C.S16.01
Polar ICL2 S 158 - s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 S 158 - s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 S 158 - s17s18 R 282 C.s17s18.11
Hydrophobic TM5 G 253 5x72 S6 K 73 N.S6.03
Polar TM5 H 249 5x68 S5 Y 59 N.S5.12
Aromatic TM5 H 249 5x68 S5 Y 59 N.S5.12
Hydrophobic TM5 H 249 5x68 S5 Y 59 N.S5.12
Hydrophobic ICL2 S 158 - s8s9 D 132 N.s8s9.06
Hydrophobic TM3 I 152 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 152 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 P 252 5x71 S6 K 73 N.S6.03
Van-der-waals TM5 P 252 5x71 S6 K 73 N.S6.03
Hydrophobic TM5 P 252 5x71 S6 F 71 N.S6.01
Ionic ICL2 H 155 - S16 D 244 C.S16.01
Polar ICL2 H 155 - S16 D 244 C.S16.01
Hydrophobic ICL2 H 155 - S16 D 244 C.S16.01
Van-der-waals ICL2 H 155 - S16 D 244 C.S16.01
Polar ICL2 K 159 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 K 159 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 K 159 - s8s9 D 132 N.s8s9.06
Ionic TM6 R 262 6x29 s5s6 E 65 N.s5s6.06
Polar TM6 R 262 6x29 s5s6 E 65 N.s5s6.06
Van-der-waals TM6 R 262 6x29 s5s6 E 65 N.s5s6.06
Polar TM6 Y 259 6x26 s5s6 T 70 N.s5s6.11
Hydrophobic TM6 Y 259 6x26 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 Y 259 6x26 s5s6 T 70 N.s5s6.11
Hydrophobic TM3 I 152 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 L 246 5x65 s5s6 I 67 N.s5s6.08
Ionic ICL2 K 159 - s5s6 D 63 N.s5s6.04
Polar ICL2 K 159 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 K 159 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 K 159 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 L 156 - S16 Y 246 C.S16.03
Van-der-waals ICL2 L 156 - S16 Y 246 C.S16.03
Hydrophobic ICL2 K 159 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 K 159 - s5s6 R 61 N.s5s6.02
Hydrophobic TM5 P 252 5x71 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 P 252 5x71 s15s16 L 240 C.s15s16.02
Hydrophobic TM3 R 148 3x50 s5s6 I 67 N.s5s6.08
Polar ICL2 L 156 - s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 L 156 - s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 L 156 - s17s18 R 282 C.s17s18.11
Polar TM6 Y 259 6x26 S6 F 71 N.S6.01
Aromatic TM6 Y 259 6x26 S6 F 71 N.S6.01
Hydrophobic TM6 Y 259 6x26 S6 F 71 N.S6.01
Van-der-waals TM6 Y 259 6x26 S6 F 71 N.S6.01
Hydrophobic TM3 I 152 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 152 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic H8 N 329 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 329 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 R 262 6x29 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 R 262 6x29 s5s6 G 68 N.s5s6.09
Polar C-term F 357 - s9s10 E 152 N.s9s10.07
Hydrophobic C-term F 357 - s9s10 E 152 N.s9s10.07
Van-der-waals C-term F 357 - s9s10 E 152 N.s9s10.07
Hydrophobic C-term F 357 - S5 M 52 N.S5.05
Van-der-waals C-term F 357 - S5 M 52 N.S5.05
Polar ICL2 H 155 - S5 Y 59 N.S5.12
Aromatic ICL2 H 155 - S5 Y 59 N.S5.12
Hydrophobic ICL2 H 155 - S5 Y 59 N.S5.12
Van-der-waals ICL2 H 155 - S5 Y 59 N.S5.12
Ionic H8 K 334 8x52 s5s6 E 65 N.s5s6.06
Polar H8 K 334 8x52 s5s6 E 65 N.s5s6.06
Van-der-waals H8 K 334 8x52 s5s6 E 65 N.s5s6.06
Polar TM4 K 162 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic TM5 L 246 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 246 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM4 S 161 4x38 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 S 161 4x38 s8s9 E 131 N.s8s9.05
Polar ICL2 H 155 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 H 155 - s5s6 R 61 N.s5s6.02
Polar ICL2 H 155 - S16 Y 246 C.S16.03
Aromatic ICL2 H 155 - S16 Y 246 C.S16.03
Hydrophobic ICL2 H 155 - S16 Y 246 C.S16.03
Van-der-waals ICL2 H 155 - S16 Y 246 C.S16.03
Polar TM5 H 249 5x68 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 H 249 5x68 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 H 249 5x68 s15s16 S 242 C.s15s16.04
Polar TM6 T 266 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 266 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 266 6x33 s5s6 I 67 N.s5s6.08
Polar ICL2 E 157 - s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 E 157 - s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 E 157 - s17s18 R 282 C.s17s18.11
Polar H8 R 345 8x63 s20c E 383 C.s20c.17
Van-der-waals H8 R 345 8x63 s20c E 383 C.s20c.17
Hydrophobic TM5 P 252 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic C-term V 355 - s9s10 T 154 N.s9s10.09
Van-der-waals C-term V 355 - s9s10 T 154 N.s9s10.09
Hydrophobic H8 N 331 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 331 8x49 s5s6 E 65 N.s5s6.06
Polar TM6 Y 259 6x26 S6 R 72 N.S6.02
Hydrophobic C-term F 357 - S9 K 144 N.S9.08
Van-der-waals C-term F 357 - S9 K 144 N.S9.08