S-arrestin - Y2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
Y2 75.0
S-arrestin 81.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 K 245 5x64 S5 Y 71 N.S5.12
Hydrophobic TM5 K 245 5x64 S5 Y 71 N.S5.12
Van-der-waals TM5 K 245 5x64 S5 Y 71 N.S5.12
Hydrophobic TM3 I 152 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 I 152 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 M 269 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 269 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 L 270 6x37 s5s6 I 79 N.s5s6.08
Ionic C-term H 350 - s5s6 D 75 N.s5s6.04
Polar C-term H 350 - s5s6 D 75 N.s5s6.04
Hydrophobic C-term H 350 - s5s6 D 75 N.s5s6.04
Van-der-waals C-term H 350 - s5s6 D 75 N.s5s6.04
Polar TM3 V 153 3x55 S5 Y 71 N.S5.12
Hydrophobic TM3 I 152 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 152 3x54 S6 F 83 N.S6.01
Polar ICL2 H 155 - S5 Y 71 N.S5.12
Aromatic ICL2 H 155 - S5 Y 71 N.S5.12
Hydrophobic ICL2 H 155 - S5 Y 71 N.S5.12
Van-der-waals ICL2 H 155 - S5 Y 71 N.S5.12
Hydrophobic TM2 T 85 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 85 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 S 158 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 S 158 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 K 159 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 159 - s8s9 K 145 N.s8s9.09
Ionic TM6 R 262 6x29 s9s10 D 166 N.s9s10.08
Polar TM6 R 262 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic TM3 R 148 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 P 252 5x71 S6 D 86 N.S6.04
Van-der-waals TM5 P 252 5x71 S6 D 86 N.S6.04
Polar H8 N 329 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 329 8x47 s5s6 D 77 N.s5s6.06
Polar H8 N 329 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 N 329 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 329 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 T 266 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 266 6x33 s5s6 I 79 N.s5s6.08
Polar ICL2 S 158 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 S 158 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 S 158 - s8s9 K 145 N.s8s9.09
Polar TM5 K 245 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 245 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 245 5x64 s15s16 Y 254 C.s15s16.03
Polar TM5 G 253 5x72 S6 D 86 N.S6.04
Hydrophobic ICL2 L 156 - S9 C 147 N.S9.01
Van-der-waals ICL2 L 156 - S9 C 147 N.S9.01
Van-der-waals H8 S 330 8x48 s5s6 G 80 N.s5s6.09
Polar TM2 T 83 2x37 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 T 83 2x37 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 T 83 2x37 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 P 252 5x71 s17s18 V 324 C.s17s18.40
Hydrophobic TM3 I 152 3x54 s5s6 I 76 N.s5s6.05
Polar TM6 N 256 6x23 S6 D 86 N.S6.04
Polar TM5 S 251 5x70 S6 D 86 N.S6.04
Van-der-waals TM5 S 251 5x70 S6 D 86 N.S6.04
Polar TM5 H 249 5x68 s15s16 Y 254 C.s15s16.03
Aromatic TM5 H 249 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 H 249 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 H 249 5x68 s15s16 Y 254 C.s15s16.03
Polar ICL2 K 159 - s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 K 159 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 K 159 - s5s6 Q 73 N.s5s6.02
Hydrophobic TM5 L 246 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 246 5x65 s5s6 L 81 N.s5s6.10
Aromatic TM5 H 249 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 H 249 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 H 249 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 P 252 5x71 S6 L 87 N.S6.05
Van-der-waals TM5 P 252 5x71 S6 L 87 N.S6.05
Hydrophobic ICL2 H 155 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 H 155 - s8s9 K 145 N.s8s9.09
Polar TM2 N 86 2x40 s5s6 D 77 N.s5s6.06
Polar ICL2 K 159 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 K 159 - s8s9 D 142 N.s8s9.06
Ionic TM6 H 258 6x25 s9s10 D 166 N.s9s10.08
Polar TM6 H 258 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 H 258 6x25 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 H 258 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 262 6x29 s5s6 L 81 N.s5s6.10
Polar TM3 R 148 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 148 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 148 3x50 s5s6 V 78 N.s5s6.07
Ionic ICL2 H 155 - S16 D 257 C.S16.01
Polar ICL2 H 155 - S16 D 257 C.S16.01
Hydrophobic ICL2 H 155 - S16 D 257 C.S16.01
Van-der-waals ICL2 H 155 - S16 D 257 C.S16.01
Polar TM3 I 152 3x54 S5 Y 71 N.S5.12
Hydrophobic TM5 H 249 5x68 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 H 249 5x68 s15s16 L 253 C.s15s16.02
Hydrophobic ICL2 L 156 - S8 L 136 N.S8.03
Van-der-waals ICL2 L 156 - S8 L 136 N.S8.03
Polar TM5 V 250 5x69 S6 R 85 N.S6.03
Hydrophobic TM5 V 250 5x69 S6 R 85 N.S6.03
Van-der-waals TM5 V 250 5x69 S6 R 85 N.S6.03
Polar ICL2 E 157 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 E 157 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 E 157 - s8s9 K 145 N.s8s9.09
Polar TM6 Y 259 6x26 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 Y 259 6x26 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 S 251 5x70 S6 R 85 N.S6.03
Van-der-waals TM5 S 251 5x70 S6 R 85 N.S6.03
Polar TM6 R 262 6x29 s5s6 T 82 N.s5s6.11
Polar ICL2 H 155 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 H 155 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 H 155 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 L 156 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 156 - s8s9 K 145 N.s8s9.09
Hydrophobic TM5 K 245 5x64 s15s16 S 255 C.s15s16.04
Van-der-waals TM5 K 245 5x64 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 L 156 - S15 V 251 C.S15.14
Polar C-term E 352 - s5s6 E 74 N.s5s6.03
Hydrophobic C-term E 352 - s5s6 E 74 N.s5s6.03
Van-der-waals C-term E 352 - s5s6 E 74 N.s5s6.03
Hydrophobic TM5 P 252 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 P 252 5x71 S6 R 85 N.S6.03
Polar H8 N 331 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 331 8x49 s5s6 D 77 N.s5s6.06
Ionic C-term K 360 - s20c E 392 C.s20c.11
Polar C-term K 360 - s20c E 392 C.s20c.11
Van-der-waals C-term K 360 - s20c E 392 C.s20c.11
Hydrophobic ICL2 L 156 - S16 Y 259 C.S16.03
Van-der-waals ICL2 L 156 - S16 Y 259 C.S16.03
Hydrophobic TM6 Y 259 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 Y 259 6x26 S6 R 84 N.S6.02
Ionic C-term H 350 - s5s6 D 77 N.s5s6.06
Polar C-term H 350 - s5s6 D 77 N.s5s6.06
Hydrophobic C-term H 350 - s5s6 D 77 N.s5s6.06
Hydrophobic TM6 T 266 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 T 266 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 L 246 5x65 S6 F 83 N.S6.01
Van-der-waals TM5 L 246 5x65 S6 F 83 N.S6.01