Gi3 - Y2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
Y2 78.6
Gαi3 87.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
01
iPTM Score: 0.7
01
PAE mean: 12.6
031


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:
E52G.HNQ06Q17R24H.HAI01E03G.S2E02G.h2s4D13N19Y26G.H5GproteinR6x29S8x48N-S-R-V-P-T-S5x70H-N-N-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNH.HAG.S2G.h2s4G.H5GPCR segments:ICL2TM5TM6H8C-term

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x503x533x544x405x645x655x685x705x715x726x256x296x336x366x378x478x488x49G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.16G.H5.15G.H5.13G.H5.12G.H5.10G.H5.09G.H5.06G.S6.02G.h4s6.12G.h4s6.09G.h2s4.02G.H2.09G.S3.01G.S2.03G.S2.02G.S2.01G.hfs2.04H.hdhe.02H.HA.24H.HA.17H.HA.10H.HA.07H.HA.06H.HA.03G.hns1.03G.hns1.02G.HN.52G.HN.44Res. Pos.Y2 (AFM_NPY2R_HUMAN_GNAI3_HUMAN)- (AFM_NPY2R_HUMAN_GNAI3_HUMAN)--------------------TRCIRKLHSPGHRTMLNSNTRCIRKLHSPGHRTMLNSNLECLNLDITDEFDAYDYGKHIEIVELEKAKEQYVQRQ

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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