Beta-arrestin-1 - Y4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
Y4 74.4
Beta-arrestin-1 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Aromatic TM5 F 248 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 F 248 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 F 248 5x72 s15s16 F 244 C.s15s16.03
Polar TM2 T 76 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic ICL1 A 73 12x51 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 I 80 2x43 s5s6 V 70 N.s5s6.07
Polar ICL1 E 71 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 E 71 12x49 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 E 71 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 R 139 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 139 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 F 248 5x72 s15s16 L 243 C.s15s16.02
Hydrophobic TM5 V 247 5x71 S6 K 77 N.S6.03
Polar ICL2 T 147 - S16 A 247 C.S16.01
Hydrophobic ICL2 T 147 - S16 A 247 C.S16.01
Van-der-waals ICL2 T 147 - S16 A 247 C.S16.01
Hydrophobic TM6 M 260 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 M 260 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 143 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 143 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 143 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 L 267 6x37 s5s6 L 71 N.s5s6.08
Polar ICL2 P 146 - S5 Y 63 N.S5.12
Hydrophobic ICL2 P 146 - S5 Y 63 N.S5.12
Van-der-waals ICL2 P 146 - S5 Y 63 N.S5.12
Hydrophobic TM6 V 266 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 F 248 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 F 248 5x72 S6 K 77 N.S6.03
Polar TM3 N 145 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 N 145 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 N 145 3x56 s15s16 N 245 C.s15s16.04
Ionic H8 K 331 8x52 s20c E 407 C.s20c.17
Polar H8 K 331 8x52 s20c E 407 C.s20c.17
Hydrophobic H8 K 331 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 K 331 8x52 s20c E 407 C.s20c.17
Hydrophobic TM2 T 76 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 T 76 2x39 s5s6 V 70 N.s5s6.07
Ionic ICL2 K 150 - s8s9 D 135 N.s8s9.06
Polar ICL2 K 150 - s8s9 D 135 N.s8s9.06
Polar TM6 H 259 6x29 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 H 259 6x29 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 H 259 6x29 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 241 5x65 s5s6 L 73 N.s5s6.10
Polar H8 T 327 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 T 327 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 L 142 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 I 143 3x54 S6 F 75 N.S6.01
Hydrophobic TM5 L 241 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 L 241 5x65 S6 F 75 N.S6.01
Polar TM6 R 256 6x26 S6 R 76 N.S6.02
Hydrophobic TM6 R 256 6x26 S6 R 76 N.S6.02
Van-der-waals TM6 R 256 6x26 S6 R 76 N.S6.02
Polar H8 N 326 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 326 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 326 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 I 143 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 H 259 6x29 s5s6 L 73 N.s5s6.10
Polar H8 T 327 8x48 s5s6 G 72 N.s5s6.09
Hydrophobic H8 T 327 8x48 s5s6 G 72 N.s5s6.09
Van-der-waals H8 T 327 8x48 s5s6 G 72 N.s5s6.09
Polar ICL2 T 147 - S5 Y 63 N.S5.12
Hydrophobic ICL2 T 147 - S5 Y 63 N.S5.12
Van-der-waals ICL2 T 147 - S5 Y 63 N.S5.12
Hydrophobic ICL2 T 147 - S15 I 241 C.S15.14
Van-der-waals ICL2 T 147 - S15 I 241 C.S15.14
Hydrophobic ICL2 P 146 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 146 - s15s16 N 245 C.s15s16.04
Polar TM5 R 240 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 240 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 240 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 L 255 6x25 s9s10 K 157 N.s9s10.09
Polar ICL2 T 147 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 T 147 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 T 147 - s15s16 N 245 C.s15s16.04
Hydrophobic TM7 Y 322 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 322 7x53 s5s6 V 70 N.s5s6.07
Polar H8 N 328 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 328 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 328 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 Q 244 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 Q 244 5x68 S6 F 75 N.S6.01
Hydrophobic ICL2 K 150 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 K 150 - s5s6 R 65 N.s5s6.02
Polar ICL2 T 147 - S16 Y 249 C.S16.03
Hydrophobic ICL2 T 147 - S16 Y 249 C.S16.03
Van-der-waals ICL2 T 147 - S16 Y 249 C.S16.03
Hydrophobic TM3 L 142 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 L 142 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 Q 244 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 244 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 V 263 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 V 263 6x33 s5s6 L 73 N.s5s6.10
Ionic H8 K 331 8x52 s20c E 405 C.s20c.15
Polar H8 K 331 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 K 331 8x52 s20c E 405 C.s20c.15
Hydrophobic TM2 N 74 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 74 2x37 s5s6 D 67 N.s5s6.04
Polar TM6 H 259 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 H 259 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 H 259 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic H8 N 326 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 N 326 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 V 263 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 263 6x33 s5s6 L 71 N.s5s6.08