Arrestin-C - Y4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
Y4 71.5
Arrestin-C 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 N 74 2x37 s5s6 D 62 N.s5s6.03
Hydrophobic TM2 N 74 2x37 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 N 74 2x37 s5s6 D 62 N.s5s6.03
Hydrophobic TM6 V 263 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 K 150 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 K 150 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 T 147 - s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 T 147 - s15s16 L 243 C.s15s16.05
Ionic ICL2 K 150 - s5s6 D 63 N.s5s6.04
Polar ICL2 K 150 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 K 150 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 E 71 12x49 s5s6 D 62 N.s5s6.03
Hydrophobic TM3 R 139 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 T 252 - S6 V 77 N.S6.07
Hydrophobic TM6 L 267 6x37 s5s6 I 67 N.s5s6.08
Polar H8 N 326 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 N 326 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 326 8x47 s5s6 V 66 N.s5s6.07
Polar ICL2 P 146 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 146 - s5s6 R 61 N.s5s6.02
Hydrophobic TM3 I 143 3x54 s5s6 L 69 N.s5s6.10
Polar ICL3 Y 253 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 Y 253 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 Y 253 - s9s10 E 152 N.s9s10.07
Hydrophobic TM3 I 143 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 143 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 L 255 6x25 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 L 255 6x25 s9s10 T 154 N.s9s10.09
Hydrophobic ICL3 T 252 - s9s10 E 152 N.s9s10.07
Hydrophobic TM2 I 80 2x43 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 I 80 2x43 s5s6 V 66 N.s5s6.07
Polar TM3 R 139 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 139 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 139 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic H8 N 326 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 326 8x47 s5s6 E 65 N.s5s6.06
Polar TM6 S 254 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 S 254 6x24 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 S 254 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM3 L 142 3x53 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 L 142 3x53 s5s6 D 63 N.s5s6.04
Polar H8 T 327 8x48 s5s6 G 68 N.s5s6.09
Van-der-waals H8 T 327 8x48 s5s6 G 68 N.s5s6.09
Hydrophobic TM2 T 76 2x39 s5s6 V 66 N.s5s6.07
Polar H8 T 327 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 328 8x49 s5s6 V 66 N.s5s6.07
Polar ICL2 T 147 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 T 147 - s15s16 Y 241 C.s15s16.03
Polar H8 N 328 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 328 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 328 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 P 146 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 146 - s15s16 Y 241 C.s15s16.03
Ionic ICL1 E 71 12x49 s8s9 K 135 N.s8s9.09
Polar ICL1 E 71 12x49 s8s9 K 135 N.s8s9.09
Hydrophobic ICL1 E 71 12x49 s8s9 K 135 N.s8s9.09
Van-der-waals ICL1 E 71 12x49 s8s9 K 135 N.s8s9.09
Hydrophobic TM6 V 263 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 F 248 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 F 248 5x72 S6 K 73 N.S6.03