Arrestin-C - Y5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
Y5 79.3
Arrestin-C 82.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 K 245 5x72 s17s18 G 306 C.s17s18.35
Hydrophobic TM6 S 365 6x32 s5s6 L 69 N.s5s6.10
Ionic TM3 H 145 3x56 S16 D 244 C.S16.01
Polar TM3 H 145 3x56 S16 D 244 C.S16.01
Hydrophobic TM3 H 145 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 H 145 3x56 S16 D 244 C.S16.01
Hydrophobic TM3 I 143 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 143 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 I 143 3x54 s5s6 L 64 N.s5s6.05
Ionic TM6 K 361 6x28 s9s10 E 152 N.s9s10.07
Polar TM6 K 361 6x28 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 K 361 6x28 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 K 361 6x28 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 I 359 6x26 S6 V 77 N.S6.07
Hydrophobic TM3 I 143 3x54 S5 Y 59 N.S5.12
Van-der-waals TM3 I 143 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 R 139 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 139 3x50 s5s6 V 66 N.s5s6.07
Polar TM6 R 362 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 R 362 6x29 s5s6 T 70 N.s5s6.11
Polar ICL2 S 148 - S16 Y 246 C.S16.03
Hydrophobic ICL2 S 148 - S16 Y 246 C.S16.03
Van-der-waals ICL2 S 148 - S16 Y 246 C.S16.03
Polar ICL2 S 148 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 P 146 - S5 Y 59 N.S5.12
Hydrophobic ICL3 M 254 - s6h1 P 90 N.s6h1.07
Polar ICL3 S 355 - S6 V 77 N.S6.07
Hydrophobic ICL3 S 355 - S6 V 77 N.S6.07
Van-der-waals ICL3 S 355 - S6 V 77 N.S6.07
Hydrophobic TM6 L 370 6x37 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 R 369 6x36 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 R 369 6x36 s5s6 L 69 N.s5s6.10
Polar H8 N 429 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 429 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 429 8x47 s5s6 E 65 N.s5s6.06
Polar TM7 L 424 7x52 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 L 424 7x52 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 L 424 7x52 s5s6 I 67 N.s5s6.08
Polar TM3 R 139 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 R 139 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 I 238 5x65 S6 F 71 N.S6.01
Van-der-waals TM5 I 238 5x65 S6 F 71 N.S6.01
Hydrophobic ICL2 I 147 - s17s18 G 283 C.s17s18.12
Hydrophobic TM6 I 359 6x26 S6 L 75 N.S6.05
Hydrophobic TM6 I 359 6x26 S6 D 74 N.S6.04
Van-der-waals TM6 I 359 6x26 S6 D 74 N.S6.04
Hydrophobic TM6 L 373 6x40 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 L 373 6x40 s5s6 V 66 N.s5s6.07
Polar H8 N 430 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 430 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 430 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic ICL1 Q 72 12x50 s8s9 A 133 N.s8s9.07
Hydrophobic TM5 C 240 5x67 S6 K 73 N.S6.03
Van-der-waals TM5 C 240 5x67 S6 K 73 N.S6.03
Hydrophobic TM5 I 238 5x65 S6 R 72 N.S6.02
Hydrophobic ICL3 R 351 - S6 Q 78 N.S6.08
Van-der-waals ICL3 R 351 - S6 Q 78 N.S6.08
Hydrophobic ICL2 P 146 - S15 V 238 C.S15.14
Polar TM7 L 428 7x56 s5s6 G 68 N.s5s6.09
Hydrophobic TM7 L 428 7x56 s5s6 G 68 N.s5s6.09
Van-der-waals TM7 L 428 7x56 s5s6 G 68 N.s5s6.09
Polar TM3 K 144 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 K 144 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 K 144 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM6 L 370 6x37 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 R 358 6x25 S6 V 77 N.S6.07
Van-der-waals TM6 R 358 6x25 S6 V 77 N.S6.07
Hydrophobic TM2 V 76 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 V 76 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 R 358 6x25 S5 M 52 N.S5.05
Van-der-waals TM6 R 358 6x25 S5 M 52 N.S5.05
Polar ICL2 I 147 - S16 Y 246 C.S16.03
Hydrophobic ICL2 I 147 - S16 Y 246 C.S16.03
Van-der-waals ICL2 I 147 - S16 Y 246 C.S16.03
Polar TM5 C 240 5x67 S6 D 74 N.S6.04
Hydrophobic TM5 C 240 5x67 S6 D 74 N.S6.04
Van-der-waals TM5 C 240 5x67 S6 D 74 N.S6.04
Hydrophobic ICL2 P 146 - S9 C 137 N.S9.01
Hydrophobic TM2 V 76 2x39 s5s6 L 64 N.s5s6.05
Polar TM6 R 369 6x36 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 R 369 6x36 s5s6 G 68 N.s5s6.09
Polar TM2 T 74 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 74 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 74 2x37 s5s6 D 63 N.s5s6.04
Polar TM5 S 237 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 S 237 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 S 237 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 I 147 - S15 V 238 C.S15.14
Van-der-waals ICL2 I 147 - S15 V 238 C.S15.14
Hydrophobic TM7 L 428 7x56 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 L 428 7x56 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 V 234 5x61 S6 F 71 N.S6.01
Van-der-waals TM5 V 234 5x61 S6 F 71 N.S6.01
Polar TM5 R 236 5x63 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 236 5x63 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 236 5x63 s15s16 Y 241 C.s15s16.03
Polar ICL2 N 149 - s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 N 149 - s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 N 149 - s17s18 R 282 C.s17s18.11
Hydrophobic TM6 V 366 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 V 366 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 I 238 5x65 S6 K 73 N.S6.03
Polar TM5 S 237 5x64 S5 Y 59 N.S5.12
Hydrophobic TM3 M 142 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 M 142 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 P 146 - S5 F 57 N.S5.10
Polar TM6 R 362 6x29 S6 R 72 N.S6.02
Hydrophobic TM6 R 362 6x29 S6 R 72 N.S6.02
Van-der-waals TM6 R 362 6x29 S6 R 72 N.S6.02
Hydrophobic TM6 L 373 6x40 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 373 6x40 s5s6 I 67 N.s5s6.08
Polar H8 G 431 8x49 s5s6 E 65 N.s5s6.06
Polar TM3 R 139 3x50 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 T 74 2x37 s8s9 A 133 N.s8s9.07
Ionic TM6 R 362 6x29 S6 D 74 N.S6.04
Polar TM6 R 362 6x29 S6 D 74 N.S6.04
Hydrophobic TM6 R 362 6x29 S6 D 74 N.S6.04
Van-der-waals TM6 R 362 6x29 S6 D 74 N.S6.04
Hydrophobic TM3 M 142 3x53 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 M 142 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 M 142 3x53 s5s6 D 63 N.s5s6.04
Ionic H8 H 441 8x59 s20c E 386 C.s20c.20
Polar H8 H 441 8x59 s20c E 386 C.s20c.20
Hydrophobic H8 H 441 8x59 s20c E 386 C.s20c.20
Van-der-waals H8 H 441 8x59 s20c E 386 C.s20c.20
Polar TM3 H 145 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 H 145 3x56 s15s16 S 242 C.s15s16.04
Ionic ICL3 R 354 - s6h1 E 86 N.s6h1.03
Polar ICL3 R 354 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL3 R 354 - s6h1 E 86 N.s6h1.03
Van-der-waals ICL3 R 354 - s6h1 E 86 N.s6h1.03
Polar TM6 R 369 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 R 369 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 R 369 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 I 147 - S15 T 236 C.S15.12
Hydrophobic ICL2 I 147 - S8 L 126 N.S8.03
Van-der-waals ICL2 I 147 - S8 L 126 N.S8.03