S-arrestin - Y5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
Y5 75.7
S-arrestin 80.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 18.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL3 R 351 - s7s8 T 125 N.s7s8.01
Hydrophobic TM2 V 76 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 V 76 2x39 s5s6 V 78 N.s5s6.07
Polar TM6 R 362 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 R 362 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 R 362 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM3 M 142 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 M 142 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 L 370 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 R 369 6x36 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 I 147 - S8 L 136 N.S8.03
Van-der-waals ICL2 I 147 - S8 L 136 N.S8.03
Polar ICL2 P 146 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 146 - s8s9 K 145 N.s8s9.09
Ionic TM6 R 358 6x25 s9s10 E 165 N.s9s10.07
Polar TM6 R 358 6x25 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 R 358 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 358 6x25 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 R 358 6x25 S6 R 84 N.S6.02
Van-der-waals TM6 R 358 6x25 S6 R 84 N.S6.02
Hydrophobic TM5 V 234 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 V 234 5x61 s5s6 L 81 N.s5s6.10
Ionic TM6 R 358 6x25 S6 D 86 N.S6.04
Polar TM6 R 358 6x25 S6 D 86 N.S6.04
Hydrophobic TM6 R 358 6x25 S6 D 86 N.S6.04
Van-der-waals TM6 R 358 6x25 S6 D 86 N.S6.04
Hydrophobic ICL2 P 146 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 146 - s15s16 S 255 C.s15s16.04
Ionic TM5 R 248 5x75 s17s18 D 321 C.s17s18.37
Polar TM5 R 248 5x75 s17s18 D 321 C.s17s18.37
Van-der-waals TM5 R 248 5x75 s17s18 D 321 C.s17s18.37
Hydrophobic TM6 I 359 6x26 S6 R 85 N.S6.03
Polar ICL2 S 148 - S16 Y 259 C.S16.03
Hydrophobic H8 M 445 8x63 s20c E 405 C.s20c.24
Van-der-waals H8 M 445 8x63 s20c E 405 C.s20c.24
Polar ICL2 N 149 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 N 149 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 N 149 - s8s9 D 142 N.s8s9.06
Polar TM5 K 245 5x72 S6 L 87 N.S6.05
Polar ICL2 I 147 - S16 Y 259 C.S16.03
Hydrophobic ICL2 I 147 - S16 Y 259 C.S16.03
Van-der-waals ICL2 I 147 - S16 Y 259 C.S16.03
Ionic TM6 K 361 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 K 361 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 K 361 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 K 361 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic ICL2 I 147 - S16 D 257 C.S16.01
Van-der-waals ICL2 I 147 - S16 D 257 C.S16.01
Hydrophobic ICL2 I 147 - S15 V 251 C.S15.14
Van-der-waals ICL2 I 147 - S15 V 251 C.S15.14
Hydrophobic TM6 I 359 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 I 359 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 V 366 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 366 6x33 s5s6 L 81 N.s5s6.10
Polar TM5 G 241 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 G 241 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 G 241 5x68 S6 R 85 N.S6.03
Ionic H8 H 441 8x59 s20c E 405 C.s20c.24
Polar H8 H 441 8x59 s20c E 405 C.s20c.24
Hydrophobic H8 H 441 8x59 s20c E 405 C.s20c.24
Van-der-waals H8 H 441 8x59 s20c E 405 C.s20c.24
Polar TM6 R 362 6x29 s5s6 G 80 N.s5s6.09
Hydrophobic TM5 K 245 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 K 245 5x72 S6 R 85 N.S6.03
Ionic H8 D 435 8x53 s20c R 398 C.s20c.17
Polar H8 D 435 8x53 s20c R 398 C.s20c.17
Hydrophobic TM6 L 370 6x37 s5s6 L 81 N.s5s6.10
Polar H8 N 430 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 430 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 430 8x48 s5s6 D 77 N.s5s6.06
Polar TM7 L 428 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic ICL3 I 255 - s7s8 Y 129 N.s7s8.05
Polar ICL3 R 351 - S6 S 90 N.S6.08
Hydrophobic ICL3 R 351 - S6 S 90 N.S6.08
Van-der-waals ICL3 R 351 - S6 S 90 N.S6.08
Polar ICL3 S 355 - S6 D 86 N.S6.04
Hydrophobic ICL3 S 355 - S6 D 86 N.S6.04
Hydrophobic TM2 T 74 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 T 74 2x37 s5s6 D 75 N.s5s6.04
Ionic TM6 K 361 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM5 I 238 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 I 238 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 V 366 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic ICL3 R 354 - S6 F 89 N.S6.07
Hydrophobic ICL3 S 355 - S6 Y 88 N.S6.06
Polar ICL2 P 146 - S5 Y 71 N.S5.12
Hydrophobic ICL2 P 146 - S5 Y 71 N.S5.12
Van-der-waals ICL2 P 146 - S5 Y 71 N.S5.12
Polar H8 N 429 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 429 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 429 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 I 80 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 139 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 139 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 T 74 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 T 74 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 I 147 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL3 S 355 - S6 F 89 N.S6.07
Polar TM6 R 369 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 R 369 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 R 369 6x36 s5s6 I 79 N.s5s6.08
Polar ICL2 I 147 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 I 147 - s8s9 K 145 N.s8s9.09
Polar ICL3 R 351 - S6 Y 88 N.S6.06
Hydrophobic ICL3 R 351 - S6 Y 88 N.S6.06
Van-der-waals ICL3 R 351 - S6 Y 88 N.S6.06
Polar ICL2 N 149 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 N 149 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 N 149 - s8s9 K 145 N.s8s9.09
Hydrophobic TM5 K 245 5x72 s17s18 V 324 C.s17s18.40
Polar ICL2 S 148 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 S 148 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 S 148 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 P 146 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 146 - s15s16 Y 254 C.s15s16.03
Hydrophobic H8 N 429 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 139 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 I 79 N.s5s6.08
Polar ICL2 I 147 - S5 Y 71 N.S5.12
Hydrophobic ICL2 I 147 - S5 Y 71 N.S5.12
Van-der-waals ICL2 I 147 - S5 Y 71 N.S5.12
Hydrophobic TM3 I 143 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 143 3x54 S6 F 83 N.S6.01
Hydrophobic TM6 L 373 6x40 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 373 6x40 s5s6 I 79 N.s5s6.08