Beta-arrestin-1 - y6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
y6 69.5
Beta-arrestin-1 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 N 69 2x37 s5s6 D 67 N.s5s6.04
Polar ICL3 K 246 - S5 T 58 N.S5.07
Hydrophobic ICL3 K 247 - S9 K 147 N.S9.08
Van-der-waals ICL3 K 247 - S9 K 147 N.S9.08
Hydrophobic TM1 K 63 1x60 s8s9 E 134 N.s8s9.05
Van-der-waals TM1 K 63 1x60 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 142 - s17s18 E 313 C.s17s18.39
Van-der-waals ICL2 R 142 - s17s18 E 313 C.s17s18.39
Hydrophobic TM3 R 134 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 134 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 M 262 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 138 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 138 3x54 s5s6 L 68 N.s5s6.05
Polar TM6 R 252 6x26 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 R 252 6x26 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 252 6x26 s5s6 T 74 N.s5s6.11
Ionic ICL1 K 66 12x49 s8s9 E 134 N.s8s9.05
Polar ICL1 K 66 12x49 s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 K 66 12x49 s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 K 66 12x49 s8s9 E 134 N.s8s9.05
Ionic TM1 K 63 1x60 s5s6 E 66 N.s5s6.03
Polar TM1 K 63 1x60 s5s6 E 66 N.s5s6.03
Van-der-waals TM1 K 63 1x60 s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 K 145 - s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 K 145 - s15s16 T 246 C.s15s16.05
Ionic ICL3 K 246 - S6 D 78 N.S6.04
Polar TM1 K 63 1x60 s8s9 D 135 N.s8s9.06
Hydrophobic TM1 K 63 1x60 s8s9 D 135 N.s8s9.06
Van-der-waals TM1 K 63 1x60 s8s9 D 135 N.s8s9.06
Van-der-waals TM6 E 255 6x29 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 R 252 6x26 S6 R 76 N.S6.02
Van-der-waals TM6 R 252 6x26 S6 R 76 N.S6.02
Hydrophobic TM3 L 137 3x53 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 L 137 3x53 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 E 255 6x29 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 M 262 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 M 262 6x36 s5s6 V 70 N.s5s6.07
Ionic TM3 E 133 3x49 s5s6 R 65 N.s5s6.02
Polar TM3 E 133 3x49 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 E 133 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic ICL1 A 67 12x50 s8s9 D 135 N.s8s9.06
Ionic TM6 E 255 6x29 s8s9 K 138 N.s8s9.09
Aromatic TM6 R 252 6x26 S6 F 75 N.S6.01
Polar TM6 I 259 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 I 259 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 259 6x33 s5s6 L 71 N.s5s6.08
Polar TM2 T 71 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 T 71 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 71 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 138 3x54 s5s6 L 73 N.s5s6.10
Polar TM2 T 71 2x39 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 T 71 2x39 s5s6 R 65 N.s5s6.02
Ionic ICL3 K 247 - S9 E 145 N.S9.06
Polar ICL3 K 247 - S9 E 145 N.S9.06
Hydrophobic ICL3 K 247 - S9 E 145 N.S9.06
Van-der-waals ICL3 K 247 - S9 E 145 N.S9.06
Hydrophobic TM3 I 138 3x54 S6 F 75 N.S6.01
Polar ICL2 K 145 - s15s16 C 242 C.s15s16.01
Hydrophobic ICL2 K 145 - s15s16 C 242 C.s15s16.01
Van-der-waals ICL2 K 145 - s15s16 C 242 C.s15s16.01
Hydrophobic TM5 L 236 5x65 S6 F 75 N.S6.01
Hydrophobic TM3 L 137 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 L 137 3x53 s5s6 R 65 N.s5s6.02
Ionic ICL2 K 145 - s17s18 E 313 C.s17s18.39
Polar ICL2 K 145 - s17s18 E 313 C.s17s18.39
Van-der-waals ICL2 K 145 - s17s18 E 313 C.s17s18.39
Hydrophobic TM5 L 236 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 236 5x65 s5s6 L 73 N.s5s6.10
Polar TM6 N 249 6x23 S10 R 165 N.S10.03
Hydrophobic TM6 I 259 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 I 259 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 N 256 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 N 256 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals ICL1 K 66 12x49 s8s9 D 135 N.s8s9.06
Polar TM2 N 69 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 N 69 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 N 69 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 R 239 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 R 239 5x68 S6 F 75 N.S6.01
Polar TM6 N 249 6x23 s20c E 405 C.s20c.15
Polar ICL2 P 141 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 P 141 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 141 - s15s16 F 244 C.s15s16.03
Hydrophobic TM1 K 63 1x60 s8s9 T 136 N.s8s9.07
Van-der-waals TM1 K 63 1x60 s8s9 T 136 N.s8s9.07
Hydrophobic TM6 E 255 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 E 255 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM3 L 137 3x53 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 K 247 - S10 R 165 N.S10.03
Van-der-waals ICL3 K 247 - S10 R 165 N.S10.03
Hydrophobic TM6 I 259 6x33 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 I 259 6x33 s5s6 G 72 N.s5s6.09
Ionic TM6 E 248 6x22 s9s10 H 159 N.s9s10.11
Polar TM6 E 248 6x22 s9s10 H 159 N.s9s10.11
Hydrophobic TM6 L 263 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 263 6x37 s5s6 L 71 N.s5s6.08
Ionic ICL3 K 245 - s9s10 E 155 N.s9s10.07
Polar ICL3 K 245 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 K 245 - s9s10 E 155 N.s9s10.07
Polar TM6 E 255 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 E 255 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 E 255 6x29 s5s6 T 74 N.s5s6.11
Ionic TM6 E 248 6x22 s9s10 K 157 N.s9s10.09
Polar TM6 E 248 6x22 s9s10 K 157 N.s9s10.09
Hydrophobic TM6 E 248 6x22 s9s10 K 157 N.s9s10.09
Van-der-waals TM6 E 248 6x22 s9s10 K 157 N.s9s10.09
Polar TM2 N 69 2x37 s15s16 N 245 C.s15s16.04
Polar TM3 R 134 3x50 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 R 134 3x50 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 R 134 3x50 s5s6 D 67 N.s5s6.04