Beta-arrestin-2 - y6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
y6 69.5
Beta-arrestin-2 77.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 N 69 2x37 s5s6 E 67 N.s5s6.03
Polar ICL2 R 142 - s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 R 142 - s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 R 142 - s15s16 T 247 C.s15s16.05
Polar ICL3 K 246 - S6 L 80 N.S6.05
Hydrophobic ICL3 K 246 - S6 L 80 N.S6.05
Van-der-waals ICL3 K 246 - S6 L 80 N.S6.05
Hydrophobic TM3 I 138 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 138 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 138 3x54 s15s16 F 245 C.s15s16.03
Van-der-waals TM3 I 138 3x54 s15s16 F 245 C.s15s16.03
Ionic TM5 K 242 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 242 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 K 242 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 242 5x71 s17s18 E 314 C.s17s18.39
Ionic ICL2 K 145 - s8s9 D 136 N.s8s9.06
Polar ICL2 K 145 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 K 145 - s8s9 D 136 N.s8s9.06
Hydrophobic TM6 R 252 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 R 252 6x26 S6 R 77 N.S6.02
Polar ICL2 R 142 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 R 142 - s15s16 S 246 C.s15s16.04
Aromatic ICL1 K 66 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 K 66 12x49 s20c Y 404 C.s20c.14
Ionic TM6 R 252 6x26 s5s6 D 70 N.s5s6.06
Polar TM6 R 252 6x26 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 R 252 6x26 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 R 252 6x26 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 L 137 3x53 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 L 137 3x53 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 I 259 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 I 259 6x33 s5s6 G 73 N.s5s6.09
Polar TM5 R 239 5x68 s15s16 F 245 C.s15s16.03
Aromatic TM5 R 239 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 239 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 239 5x68 s15s16 F 245 C.s15s16.03
Polar ICL2 P 146 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 146 - s5s6 R 66 N.s5s6.02
Polar TM6 R 252 6x26 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 R 252 6x26 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 252 6x26 s5s6 S 75 N.s5s6.11
Hydrophobic TM3 R 134 3x50 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 R 134 3x50 s5s6 L 74 N.s5s6.10
Polar ICL2 P 141 - S5 Y 64 N.S5.12
Hydrophobic ICL2 P 141 - S5 Y 64 N.S5.12
Van-der-waals ICL2 P 141 - S5 Y 64 N.S5.12
Hydrophobic ICL2 R 142 - S16 Q 249 C.S16.02
Van-der-waals ICL2 R 142 - S16 Q 249 C.S16.02
Hydrophobic ICL2 R 142 - S16 A 248 C.S16.01
Van-der-waals ICL2 R 142 - S16 A 248 C.S16.01
Polar TM2 N 69 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 N 69 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 N 69 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 71 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 T 71 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 236 5x65 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 E 248 6x22 S6 F 76 N.S6.01
Van-der-waals TM6 E 248 6x22 S6 F 76 N.S6.01
Polar TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 N 249 6x23 S6 I 82 N.S6.07
Polar TM6 N 256 6x30 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 N 256 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 N 256 6x30 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 L 137 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 137 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 K 145 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 K 145 - s5s6 R 66 N.s5s6.02
Hydrophobic TM3 E 133 3x49 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 E 133 3x49 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 V 243 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 V 243 5x72 S6 K 78 N.S6.03
Hydrophobic ICL2 P 141 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 P 141 - s15s16 F 245 C.s15s16.03
Polar TM6 N 249 6x23 S6 D 79 N.S6.04
Hydrophobic TM6 N 249 6x23 S6 D 79 N.S6.04
Van-der-waals TM6 N 249 6x23 S6 D 79 N.S6.04
Hydrophobic TM3 L 137 3x53 s15s16 F 245 C.s15s16.03
Van-der-waals TM3 L 137 3x53 s15s16 F 245 C.s15s16.03
Hydrophobic TM1 K 63 1x60 s5s6 V 71 N.s5s6.07
Polar ICL2 P 141 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 P 141 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 141 - s15s16 S 246 C.s15s16.04
Hydrophobic TM2 N 69 2x37 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 N 69 2x37 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 I 259 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 259 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 E 248 6x22 S6 K 78 N.S6.03
Van-der-waals TM6 E 248 6x22 S6 K 78 N.S6.03