Arrestin-C - NTS1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NTS1 72.6
Arrestin-C 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 298 6x30 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 L 298 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic TM2 V 101 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 V 101 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 170 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 170 3x54 S6 F 71 N.S6.01
Polar ICL3 S 287 - S6 V 77 N.S6.07
Hydrophobic ICL3 F 286 - s7s8 N 119 N.s7s8.05
Hydrophobic TM5 M 266 5x68 S6 F 71 N.S6.01
Van-der-waals TM5 M 266 5x68 S6 F 71 N.S6.01
Hydrophobic C-term Y 418 - s20c E 374 C.s20c.07
Van-der-waals C-term Y 418 - s20c E 374 C.s20c.07
Hydrophobic TM3 I 170 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 170 3x54 s5s6 L 64 N.s5s6.05
Aromatic ICL3 F 286 - S6 Y 76 N.S6.06
Hydrophobic ICL3 F 286 - S6 Y 76 N.S6.06
Van-der-waals ICL3 F 286 - S6 Y 76 N.S6.06
Polar ICL2 F 174 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 F 174 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 F 174 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 K 177 34x54 S9 C 137 N.S9.01
Polar H8 S 368 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 S 368 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic ICL3 F 286 - s7s8 V 117 N.s7s8.03
Van-der-waals ICL3 F 286 - s7s8 V 117 N.s7s8.03
Polar TM2 T 100 2x38 s5s6 D 63 N.s5s6.04
Polar ICL2 K 177 34x54 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 K 177 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic TM5 L 263 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 263 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 L 162 3x46 s5s6 V 66 N.s5s6.07
Polar ICL2 K 177 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 K 177 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 K 177 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 L 305 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic H8 S 368 8x47 s5s6 G 68 N.s5s6.09
Hydrophobic ICL3 I 290 - S6 K 73 N.S6.03
Hydrophobic ICL2 F 174 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 F 174 34x51 s15s16 S 242 C.s15s16.04
Polar TM6 R 294 6x26 S6 R 72 N.S6.02
Hydrophobic TM6 R 294 6x26 S6 R 72 N.S6.02
Van-der-waals TM6 R 294 6x26 S6 R 72 N.S6.02
Hydrophobic TM2 L 105 2x43 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 L 105 2x43 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 A 169 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 169 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM2 Q 98 2x36 s8s9 A 133 N.s8s9.07
Van-der-waals TM2 Q 98 2x36 s8s9 A 133 N.s8s9.07
Hydrophobic ICL3 A 289 - S6 V 77 N.S6.07
Van-der-waals ICL3 A 289 - S6 V 77 N.S6.07
Hydrophobic TM7 V 367 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 V 367 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 V 101 2x39 s5s6 D 63 N.s5s6.04
Polar TM5 K 262 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 K 262 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 K 262 5x64 s15s16 Y 241 C.s15s16.03
Polar ICL2 M 180 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 M 180 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 M 180 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 F 174 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 F 174 34x51 S9 C 137 N.S9.01
Polar TM4 S 181 4x38 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 S 181 4x38 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 S 181 4x38 s8s9 E 131 N.s8s9.05
Polar TM6 R 294 6x26 s5s6 T 70 N.s5s6.11
Hydrophobic TM5 M 266 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 M 266 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 P 173 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 173 34x50 s15s16 S 242 C.s15s16.04
Polar ICL2 F 174 34x51 S5 Y 59 N.S5.12
Aromatic ICL2 F 174 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 F 174 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 F 174 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL3 M 288 - S6 K 73 N.S6.03
Polar TM3 R 166 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 166 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 166 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 F 286 - s7s8 L 120 N.s7s8.06
Van-der-waals ICL3 F 286 - s7s8 L 120 N.s7s8.06
Hydrophobic TM6 R 294 6x26 S6 K 73 N.S6.03
Van-der-waals TM6 R 294 6x26 S6 K 73 N.S6.03
Ionic TM1 K 91 1x60 s5s6 E 65 N.s5s6.06
Polar C-term L 417 - s20c K 378 C.s20c.11
Hydrophobic C-term L 417 - s20c K 378 C.s20c.11
Hydrophobic ICL3 M 288 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 M 288 - s17s18 L 311 C.s17s18.40
Ionic ICL2 K 175 34x52 S16 D 244 C.S16.01
Polar ICL2 K 175 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 K 175 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 K 175 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 F 174 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 F 174 34x51 S8 L 126 N.S8.03
Polar H8 N 370 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 370 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 370 8x49 s5s6 E 65 N.s5s6.06
Polar ICL2 A 176 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 A 176 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 A 176 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 K 177 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 K 177 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic TM3 I 170 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 170 3x54 s5s6 I 67 N.s5s6.08
Polar TM5 Q 273 5x75 S6 K 73 N.S6.03
Hydrophobic TM5 Q 273 5x75 S6 K 73 N.S6.03
Van-der-waals TM5 Q 273 5x75 S6 K 73 N.S6.03
Hydrophobic ICL2 T 178 34x55 S16 Y 246 C.S16.03
Hydrophobic C-term Y 418 - s20c K 378 C.s20c.11
Van-der-waals C-term Y 418 - s20c K 378 C.s20c.11
Van-der-waals TM2 L 97 2x35 s5s6 E 65 N.s5s6.06
Hydrophobic ICL3 M 288 - S6 D 74 N.S6.04
Van-der-waals ICL3 M 288 - S6 D 74 N.S6.04
Hydrophobic TM5 I 259 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 M 288 - S6 L 75 N.S6.05
Van-der-waals ICL3 M 288 - S6 L 75 N.S6.05
Hydrophobic TM2 S 96 2x34 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 S 96 2x34 s5s6 D 62 N.s5s6.03
Hydrophobic TM6 A 297 6x29 s5s6 L 69 N.s5s6.10
Polar ICL2 F 174 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 F 174 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 F 174 34x51 S16 D 244 C.S16.01
Polar ICL2 P 173 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 173 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 173 34x50 S5 Y 59 N.S5.12
Polar TM6 R 294 6x26 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 R 294 6x26 s15s16 Y 241 C.s15s16.03
Hydrophobic TM7 V 367 7x56 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 V 367 7x56 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 H 172 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 R 166 3x50 s5s6 I 67 N.s5s6.08
Polar TM2 T 100 2x38 s5s6 R 61 N.s5s6.02
Polar TM2 S 99 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 S 99 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 S 99 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 F 174 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 F 174 34x51 S15 V 238 C.S15.14
Hydrophobic TM6 G 301 6x33 s5s6 I 67 N.s5s6.08
Aromatic ICL2 K 177 34x54 S5 Y 59 N.S5.12
Hydrophobic TM2 H 102 2x40 s5s6 V 66 N.s5s6.07