Beta-arrestin-1 - NTS2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NTS2 76.3
Beta-arrestin-1 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 299 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 299 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 L 280 - S5 T 56 N.S5.05
Hydrophobic ICL3 L 280 - S6 N 83 N.S6.09
Polar H8 F 365 8x50 s5s6 D 69 N.s5s6.06
Hydrophobic ICL3 L 280 - S9 F 149 N.S9.10
Hydrophobic TM3 A 136 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 136 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 R 133 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 L 141 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 141 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 141 34x51 S5 Y 63 N.S5.12
Ionic TM2 R 67 2x38 s8s9 D 135 N.s8s9.06
Polar TM2 R 67 2x38 s8s9 D 135 N.s8s9.06
Ionic ICL1 R 64 - s20c D 402 C.s20c.12
Polar ICL1 R 64 - s20c D 402 C.s20c.12
Hydrophobic ICL1 R 64 - s20c D 402 C.s20c.12
Van-der-waals ICL1 R 64 - s20c D 402 C.s20c.12
Hydrophobic TM5 T 229 5x61 s5s6 L 71 N.s5s6.08
Polar ICL1 R 64 - s20c D 401 C.s20c.11
Hydrophobic ICL1 R 64 - s20c D 401 C.s20c.11
Van-der-waals ICL1 R 64 - s20c D 401 C.s20c.11
Hydrophobic TM3 V 137 3x54 s5s6 L 71 N.s5s6.08
Polar ICL2 L 147 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 P 241 5x73 S6 K 77 N.S6.03
Van-der-waals TM5 P 241 5x73 S6 K 77 N.S6.03
Polar ICL3 S 248 - S6 N 83 N.S6.09
Hydrophobic ICL3 S 248 - S6 N 83 N.S6.09
Van-der-waals ICL3 S 248 - S6 N 83 N.S6.09
Polar TM5 Q 239 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 Q 239 5x71 S6 K 77 N.S6.03
Hydrophobic ICL3 L 280 - s9s10 L 154 N.s9s10.03
Van-der-waals ICL3 L 280 - s9s10 L 154 N.s9s10.03
Hydrophobic TM5 L 233 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 233 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 236 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 L 236 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 L 233 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 L 233 5x65 S6 F 75 N.S6.01
Van-der-waals TM3 Q 139 3x56 s15s16 N 245 C.s15s16.04
Polar ICL2 R 144 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 R 144 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 R 144 34x54 s8s9 K 138 N.s8s9.09
Polar ICL2 P 140 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 140 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 140 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 141 34x51 S9 C 140 N.S9.01
Polar H8 S 362 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 362 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 362 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 140 34x50 s5s6 G 64 N.s5s6.01
Polar H8 S 363 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic ICL3 V 281 - S6 V 81 N.S6.07
Van-der-waals ICL3 V 281 - S6 V 81 N.S6.07
Hydrophobic ICL2 R 144 34x54 s8s9 D 135 N.s8s9.06
Polar TM2 R 67 2x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM2 R 67 2x38 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 L 233 5x65 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 133 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 133 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 L 68 2x39 s5s6 L 68 N.s5s6.05
Polar TM3 C 138 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 C 138 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 A 136 3x53 s5s6 V 70 N.s5s6.07
Polar ICL3 S 248 - S6 V 81 N.S6.07
Van-der-waals ICL3 S 248 - S6 V 81 N.S6.07
Hydrophobic TM7 V 361 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 V 361 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 R 144 34x54 s8s9 A 139 N.s8s9.10
Hydrophobic TM2 L 68 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 L 68 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 141 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 L 141 34x51 S8 L 129 N.S8.03
Hydrophobic TM5 L 236 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 L 236 5x68 S6 F 75 N.S6.01
Hydrophobic TM6 S 295 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 R 144 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 R 144 34x54 s8s9 P 131 N.s8s9.02
Hydrophobic ICL2 L 141 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 141 34x51 S16 Y 249 C.S16.03
Polar H8 S 364 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 364 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 364 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 L 141 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 141 34x51 S15 I 241 C.S15.14
Hydrophobic TM7 V 361 7x56 s5s6 L 71 N.s5s6.08
Polar ICL1 R 64 - s20c K 403 C.s20c.13
Hydrophobic ICL1 R 64 - s20c K 403 C.s20c.13
Van-der-waals ICL1 R 64 - s20c K 403 C.s20c.13
Polar ICL2 R 144 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 R 144 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 144 34x54 s5s6 R 65 N.s5s6.02
Polar TM6 R 288 6x26 S6 R 76 N.S6.02
Hydrophobic TM6 R 288 6x26 S6 R 76 N.S6.02
Van-der-waals TM6 R 288 6x26 S6 R 76 N.S6.02
Polar TM6 R 288 6x26 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 288 6x26 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 L 141 34x51 S16 A 247 C.S16.01
Hydrophobic TM6 S 291 6x29 s5s6 L 73 N.s5s6.10
Polar TM7 V 361 7x56 s5s6 G 72 N.s5s6.09
Polar ICL2 R 144 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 R 144 34x54 s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 R 144 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic TM6 R 288 6x26 S6 F 75 N.S6.01
Van-der-waals TM6 R 288 6x26 S6 F 75 N.S6.01
Hydrophobic TM2 L 68 2x39 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 L 68 2x39 s5s6 D 69 N.s5s6.06
Polar ICL2 R 144 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 R 144 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 R 144 34x54 s8s9 G 137 N.s8s9.08
Polar TM6 S 295 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 S 295 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 295 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 H 283 - s9s10 E 155 N.s9s10.07
Ionic ICL1 R 64 - s20c E 404 C.s20c.14
Hydrophobic ICL1 R 64 - s20c E 404 C.s20c.14
Van-der-waals ICL1 R 64 - s20c E 404 C.s20c.14
Hydrophobic TM3 V 137 3x54 S6 F 75 N.S6.01
Ionic TM2 R 67 2x38 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 67 2x38 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 R 67 2x38 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 L 292 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 292 6x30 s5s6 L 73 N.s5s6.10