S-arrestin - OR2T11 complex model

GPCR CLASS (FAMILY)

O2 (tetrapod specific odorant)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OR2T11 84.2
S-arrestin 80.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 127 34x51 S6 R 84 N.S6.02
Hydrophobic H8 D 293 8x49 s5s6 V 78 N.s5s6.07
Van-der-waals H8 D 293 8x49 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 P 126 34x50 S6 F 83 N.S6.01
Van-der-waals ICL2 P 126 34x50 S6 F 83 N.S6.01
Hydrophobic TM2 M 56 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 M 56 2x39 s5s6 I 79 N.s5s6.08
Polar TM6 K 233 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 233 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 233 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 L 127 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 127 34x51 S5 Y 71 N.S5.12
Ionic TM6 K 233 6x32 s5s6 D 77 N.s5s6.06
Polar TM6 K 233 6x32 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 K 233 6x32 s5s6 D 77 N.s5s6.06
Van-der-waals TM6 K 233 6x32 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 L 127 34x51 S5 F 69 N.S5.10
Hydrophobic ICL2 P 130 34x54 s8s9 K 145 N.s8s9.09
Polar TM6 S 227 6x26 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 V 131 34x55 S5 Y 71 N.S5.12
Van-der-waals ICL2 V 131 34x55 S5 Y 71 N.S5.12
Hydrophobic ICL2 Y 129 34x53 S6 F 83 N.S6.01
Hydrophobic ICL2 P 126 34x50 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 V 131 34x55 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 V 131 34x55 s15s16 S 255 C.s15s16.04
Hydrophobic TM2 Y 57 2x40 s5s6 V 78 N.s5s6.07
Polar TM6 E 229 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 E 229 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 E 229 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 R 128 34x52 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 R 128 34x52 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 M 225 - s5s6 L 81 N.s5s6.10
Hydrophobic TM3 V 123 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 P 130 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 130 34x54 S5 Y 71 N.S5.12
Polar TM6 T 237 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 237 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 237 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 127 34x51 S6 F 83 N.S6.01
Van-der-waals ICL2 L 127 34x51 S6 F 83 N.S6.01
Hydrophobic TM3 A 122 3x53 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 A 122 3x53 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 127 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 L 127 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 A 122 3x53 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 130 34x54 s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 P 130 34x54 s8s9 G 144 N.s8s9.08
Hydrophobic ICL2 V 131 34x55 S16 D 257 C.S16.01
Van-der-waals ICL2 V 131 34x55 S16 D 257 C.S16.01