Beta-arrestin-2 - OR51B4 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OR51B4 83.7
Beta-arrestin-2 77.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 K 233 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 K 233 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 233 6x32 s5s6 G 73 N.s5s6.09
Polar ICL2 L 127 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 127 34x51 S16 Y 250 C.S16.03
Polar C-term A 310 - s20c K 400 C.s20c.10
Hydrophobic C-term A 310 - s20c K 400 C.s20c.10
Van-der-waals C-term A 310 - s20c K 400 C.s20c.10
Polar ICL2 C 131 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 C 131 34x55 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 C 131 34x55 s8s9 T 137 N.s8s9.07
Polar ICL2 N 130 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 N 130 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 N 130 34x54 s8s9 T 137 N.s8s9.07
Polar TM6 K 233 6x32 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 K 233 6x32 s5s6 S 75 N.s5s6.11
Polar ICL2 P 126 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 126 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 126 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 133 34x57 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 L 133 34x57 s8s9 T 137 N.s8s9.07
Hydrophobic H8 T 293 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 T 293 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 L 127 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 L 127 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 127 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 C 131 34x55 S16 Y 250 C.S16.03
Polar H8 Q 295 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic H8 Q 295 8x49 s5s6 D 68 N.s5s6.04
Van-der-waals H8 Q 295 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 A 122 3x53 s5s6 L 72 N.s5s6.08
Hydrophobic TM4 T 134 4x38 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 127 34x51 s15s16 L 244 C.s15s16.02
Van-der-waals ICL2 L 127 34x51 s15s16 L 244 C.s15s16.02
Ionic C-term R 309 - s20c D 402 C.s20c.12
Polar C-term R 309 - s20c D 402 C.s20c.12
Hydrophobic C-term R 309 - s20c D 402 C.s20c.12
Van-der-waals C-term R 309 - s20c D 402 C.s20c.12
Polar TM6 T 237 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 237 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 237 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 127 34x51 S9 C 141 N.S9.01
Hydrophobic ICL2 L 127 34x51 S5 F 62 N.S5.10
Polar ICL2 Y 129 34x53 s8s9 T 137 N.s8s9.07
Polar ICL2 L 127 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 127 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 127 34x51 S5 Y 64 N.S5.12
Van-der-waals TM6 K 233 6x32 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 S 234 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 S 234 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 Y 129 34x53 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 L 127 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 127 34x51 S16 A 248 C.S16.01
Hydrophobic ICL2 R 128 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 R 128 34x52 S16 A 248 C.S16.01
Ionic H8 R 298 8x52 s5s6 D 68 N.s5s6.04
Polar TM6 E 230 6x29 S6 K 78 N.S6.03
Ionic TM6 K 233 6x32 s5s6 D 70 N.s5s6.06
Polar TM6 K 233 6x32 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 K 233 6x32 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 I 225 5x68 S6 F 76 N.S6.01
Polar TM3 T 125 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 T 125 3x56 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 T 125 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 L 127 34x51 s15s16 F 245 C.s15s16.03
Polar ICL2 R 128 34x52 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 R 128 34x52 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 R 128 34x52 s15s16 T 247 C.s15s16.05
Hydrophobic TM2 E 55 2x37 s5s6 L 69 N.s5s6.05
Van-der-waals TM2 E 55 2x37 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 I 123 3x54 s5s6 L 74 N.s5s6.10
Polar ICL1 S 52 12x49 s5s6 R 66 N.s5s6.02
Polar ICL2 R 128 34x52 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 R 128 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 E 230 6x29 S6 F 76 N.S6.01
Van-der-waals TM6 E 230 6x29 S6 F 76 N.S6.01
Polar ICL2 N 130 34x54 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 N 130 34x54 s8s9 G 138 N.s8s9.08
Hydrophobic H8 Q 295 8x49 s5s6 V 71 N.s5s6.07
Van-der-waals H8 Q 295 8x49 s5s6 V 71 N.s5s6.07
Polar ICL2 N 130 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 P 126 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 P 126 34x50 s15s16 F 245 C.s15s16.03
Polar TM6 E 230 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 E 230 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 E 230 6x29 S6 R 77 N.S6.02
Hydrophobic TM2 M 57 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 M 57 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 127 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 127 34x51 S15 I 242 C.S15.14
Hydrophobic TM2 Y 58 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 Y 58 2x40 s5s6 V 71 N.s5s6.07
Ionic H8 R 298 8x52 s5s6 D 70 N.s5s6.06
Polar H8 R 298 8x52 s5s6 D 70 N.s5s6.06
Ionic TM2 E 55 2x37 s5s6 R 66 N.s5s6.02
Polar TM2 E 55 2x37 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 E 55 2x37 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 E 55 2x37 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 M 57 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 M 57 2x39 s5s6 L 72 N.s5s6.08