Arrestin-C - OR51B6 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OR51B6 84.7
Arrestin-C 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM2 E 55 2x37 s8s9 K 135 N.s8s9.09
Polar TM2 E 55 2x37 s8s9 K 135 N.s8s9.09
Hydrophobic TM2 E 55 2x37 s8s9 K 135 N.s8s9.09
Van-der-waals TM2 E 55 2x37 s8s9 K 135 N.s8s9.09
Polar ICL2 R 129 34x52 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 R 129 34x52 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 R 129 34x52 s15s16 Y 241 C.s15s16.03
Polar ICL2 T 131 34x54 S16 D 244 C.S16.01
Hydrophobic ICL2 T 131 34x54 S16 D 244 C.S16.01
Van-der-waals ICL2 T 131 34x54 S16 D 244 C.S16.01
Polar TM6 N 237 6x35 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 P 127 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 P 127 34x50 S6 F 71 N.S6.01
Hydrophobic TM3 T 123 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 T 123 3x53 S6 F 71 N.S6.01
Hydrophobic TM3 T 123 3x53 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 T 123 3x53 s5s6 L 69 N.s5s6.10
Polar TM6 K 234 6x32 s5s6 T 70 N.s5s6.11
Hydrophobic TM6 K 234 6x32 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 K 234 6x32 s5s6 T 70 N.s5s6.11
Hydrophobic H8 Q 296 8x49 s5s6 L 64 N.s5s6.05
Van-der-waals H8 Q 296 8x49 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 A 235 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 235 6x33 s5s6 L 69 N.s5s6.10
Polar ICL2 S 132 34x55 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 S 132 34x55 s15s16 L 243 C.s15s16.05
Polar TM6 K 234 6x32 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 K 234 6x32 s5s6 E 65 N.s5s6.06
Van-der-waals TM6 K 234 6x32 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 P 127 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 127 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 128 34x51 s15s16 L 240 C.s15s16.02
Van-der-waals ICL2 L 128 34x51 s15s16 L 240 C.s15s16.02
Polar ICL2 T 131 34x54 S5 Y 59 N.S5.12
Hydrophobic ICL2 R 129 34x52 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 R 129 34x52 s15s16 L 243 C.s15s16.05
Hydrophobic TM6 T 238 6x36 s5s6 I 67 N.s5s6.08
Polar H8 K 295 8x48 s5s6 V 66 N.s5s6.07
Hydrophobic H8 K 295 8x48 s5s6 V 66 N.s5s6.07
Van-der-waals H8 K 295 8x48 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 T 238 6x36 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 T 238 6x36 s5s6 L 69 N.s5s6.10
Polar ICL1 N 52 12x49 s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 N 52 12x49 s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 N 52 12x49 s5s6 R 61 N.s5s6.02
Hydrophobic H8 Q 296 8x49 s5s6 I 67 N.s5s6.08
Van-der-waals H8 Q 296 8x49 s5s6 I 67 N.s5s6.08
Polar ICL2 L 128 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 128 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 128 34x51 s15s16 S 242 C.s15s16.04
Ionic ICL2 R 129 34x52 s17s18 E 310 C.s17s18.39
Polar ICL2 R 129 34x52 s17s18 E 310 C.s17s18.39
Van-der-waals ICL2 R 129 34x52 s17s18 E 310 C.s17s18.39
Polar TM6 K 234 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 K 234 6x32 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 K 234 6x32 s5s6 G 68 N.s5s6.09
Polar ICL2 T 131 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 T 131 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 T 131 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 128 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 L 128 34x51 s15s16 Y 241 C.s15s16.03