Beta-arrestin-1 - OR51E1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OR51E1 85.5
Beta-arrestin-1 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 230 5x68 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 230 5x68 s5s6 L 73 N.s5s6.10
Polar ICL2 P 131 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 131 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 131 34x50 S5 Y 63 N.S5.12
Polar ICL2 L 132 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 132 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 132 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 230 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 L 230 5x68 S6 F 75 N.S6.01
Hydrophobic ICL2 L 132 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 132 34x51 S15 I 241 C.S15.14
Hydrophobic ICL1 S 56 12x49 s5s6 L 68 N.s5s6.05
Van-der-waals ICL1 S 56 12x49 s5s6 L 68 N.s5s6.05
Ionic TM6 K 237 6x32 s5s6 D 69 N.s5s6.06
Polar TM6 K 237 6x32 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 K 237 6x32 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 K 237 6x32 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 131 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 131 34x50 s15s16 F 244 C.s15s16.03
Polar TM6 K 237 6x32 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 K 237 6x32 s5s6 T 74 N.s5s6.11
Polar ICL2 R 133 34x52 s15s16 T 246 C.s15s16.05
Hydrophobic TM2 Y 62 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 Y 62 2x40 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 132 34x51 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 L 132 34x51 s15s16 F 244 C.s15s16.03
Polar ICL1 S 56 12x49 s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 S 56 12x49 s5s6 R 65 N.s5s6.02
Polar TM6 K 237 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 K 237 6x32 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 237 6x32 s5s6 G 72 N.s5s6.09
Polar TM3 R 124 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 124 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 A 127 3x53 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 A 127 3x53 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 A 135 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 A 135 34x54 s8s9 G 137 N.s8s9.08
Polar ICL2 T 136 34x55 s15s16 N 245 C.s15s16.04
Polar ICL2 R 133 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 133 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 133 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 132 34x51 S5 F 61 N.S5.10
Hydrophobic TM3 R 124 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 124 3x50 s5s6 L 71 N.s5s6.08
Ionic TM2 E 59 2x37 s8s9 K 138 N.s8s9.09
Polar TM2 E 59 2x37 s8s9 K 138 N.s8s9.09
Hydrophobic TM2 E 59 2x37 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 L 132 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 L 132 34x51 s15s16 L 243 C.s15s16.02
Polar ICL2 A 135 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 A 135 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 A 135 34x54 s8s9 T 136 N.s8s9.07
Polar ICL2 T 136 34x55 s8s9 T 136 N.s8s9.07
Ionic H8 K 298 8x48 s20c E 405 C.s20c.15
Polar H8 K 298 8x48 s20c E 405 C.s20c.15
Van-der-waals H8 K 298 8x48 s20c E 405 C.s20c.15
Hydrophobic TM3 I 128 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 128 3x54 s5s6 L 73 N.s5s6.10
Polar TM6 T 241 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 T 241 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 T 241 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic H8 T 297 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 A 234 6x29 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 234 6x29 s5s6 L 73 N.s5s6.10
Polar TM6 T 241 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 241 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 241 6x36 s5s6 L 71 N.s5s6.08
Ionic TM2 E 59 2x37 s5s6 R 65 N.s5s6.02
Polar TM2 E 59 2x37 s5s6 R 65 N.s5s6.02
Hydrophobic TM2 E 59 2x37 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 E 59 2x37 s5s6 R 65 N.s5s6.02
Hydrophobic H8 E 299 8x49 s5s6 L 68 N.s5s6.05
Hydrophobic H8 E 299 8x49 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 128 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 238 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 238 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 T 241 6x36 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 T 241 6x36 s5s6 G 72 N.s5s6.09
Polar ICL2 L 132 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 132 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 132 34x51 S5 Y 63 N.S5.12
Hydrophobic TM4 T 139 4x38 s8s9 T 136 N.s8s9.07