S-arrestin - OR51E1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OR51E1 85.3
S-arrestin 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 134 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 H 134 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 135 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 A 135 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic TM5 L 230 5x68 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 132 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 L 132 34x51 S9 C 147 N.S9.01
Ionic ICL2 R 133 34x52 S16 D 257 C.S16.01
Polar ICL2 R 133 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 R 133 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 R 133 34x52 S16 D 257 C.S16.01
Hydrophobic TM6 A 238 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 Y 62 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 Y 62 2x40 s5s6 V 78 N.s5s6.07
Polar ICL2 L 132 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 132 34x51 s15s16 S 255 C.s15s16.04
Polar ICL2 P 131 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 131 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 131 34x50 S5 Y 71 N.S5.12
Polar ICL2 R 133 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 R 133 34x52 s15s16 S 255 C.s15s16.04
Polar ICL2 L 132 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 132 34x51 S16 Y 259 C.S16.03
Hydrophobic TM6 T 241 6x36 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 T 241 6x36 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 C 129 3x55 s15s16 Y 254 C.s15s16.03
Polar TM6 K 237 6x32 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 K 237 6x32 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 T 241 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 T 241 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 L 132 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 132 34x51 S16 D 257 C.S16.01
Hydrophobic ICL1 L 57 12x50 s5s6 V 78 N.s5s6.07
Polar H8 E 299 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 E 299 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 E 299 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 T 136 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 H 134 34x53 s5s6 I 79 N.s5s6.08
Polar TM3 H 130 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 H 130 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 A 135 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 135 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 T 226 5x64 s15s16 Y 254 C.s15s16.03
Polar H8 E 299 8x49 s5s6 V 78 N.s5s6.07
Hydrophobic H8 E 299 8x49 s5s6 V 78 N.s5s6.07
Van-der-waals H8 E 299 8x49 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 A 234 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 I 128 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 128 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 P 131 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 131 34x50 s15s16 Y 254 C.s15s16.03
Polar ICL2 P 131 34x50 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 131 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 132 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 132 34x51 S15 V 251 C.S15.14
Polar ICL2 R 133 34x52 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 R 133 34x52 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 R 133 34x52 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 L 132 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 L 132 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 L 230 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 L 230 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 L 230 5x68 S6 F 83 N.S6.01
Van-der-waals TM5 L 230 5x68 S6 F 83 N.S6.01
Polar ICL2 L 132 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 132 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 132 34x51 S5 Y 71 N.S5.12
Polar TM3 R 124 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 124 3x50 s5s6 V 78 N.s5s6.07
Polar ICL2 L 132 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 132 34x51 s8s9 K 145 N.s8s9.09
Polar TM6 K 237 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 237 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 237 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 L 132 34x51 S5 F 69 N.S5.10
Ionic H8 K 298 8x48 s5s6 D 77 N.s5s6.06
Polar H8 K 298 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 298 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 298 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 E 59 2x37 s5s6 I 79 N.s5s6.08