Arrestin-C - OR51F2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OR51F2 77.8
Arrestin-C 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 E 247 6x29 S6 K 73 N.S6.03
Hydrophobic TM6 E 247 6x29 S6 K 73 N.S6.03
Van-der-waals TM6 E 247 6x29 S6 K 73 N.S6.03
Hydrophobic TM3 D 135 3x49 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 D 135 3x49 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 K 71 2x37 s5s6 L 64 N.s5s6.05
Polar TM6 K 250 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 K 250 6x32 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 K 250 6x32 s5s6 G 68 N.s5s6.09
Polar TM3 A 139 3x53 s15s16 Y 241 C.s15s16.03
Polar ICL2 L 144 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 144 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 L 144 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 R 136 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 M 73 2x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 M 73 2x39 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 A 139 3x53 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 A 139 3x53 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 144 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 144 34x51 S15 V 238 C.S15.14
Polar ICL2 P 143 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 P 143 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 143 34x50 s15s16 Y 241 C.s15s16.03
Polar TM6 E 247 6x29 S6 D 74 N.S6.04
Hydrophobic TM6 E 247 6x29 S6 D 74 N.S6.04
Van-der-waals TM6 E 247 6x29 S6 D 74 N.S6.04
Polar ICL2 R 145 34x52 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 R 145 34x52 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 R 145 34x52 s15s16 Y 241 C.s15s16.03
Polar TM6 S 244 6x26 S6 D 74 N.S6.04
Hydrophobic TM6 S 244 6x26 S6 D 74 N.S6.04
Van-der-waals TM6 S 244 6x26 S6 D 74 N.S6.04
Polar H8 Q 312 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 Q 312 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 Y 142 3x56 s15s16 Y 241 C.s15s16.03
Van-der-waals TM3 Y 142 3x56 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 K 250 6x32 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 144 34x51 S5 F 57 N.S5.10
Van-der-waals ICL2 L 144 34x51 S5 F 57 N.S5.10
Hydrophobic TM6 A 251 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 251 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 Y 146 34x53 s5s6 V 66 N.s5s6.07
Van-der-waals ICL2 Y 146 34x53 s5s6 V 66 N.s5s6.07
Ionic TM6 K 250 6x32 s5s6 E 65 N.s5s6.06
Polar TM6 K 250 6x32 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 K 250 6x32 s5s6 E 65 N.s5s6.06
Van-der-waals TM6 K 250 6x32 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 I 140 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 140 3x54 s5s6 L 69 N.s5s6.10
Ionic TM6 E 247 6x29 S6 R 72 N.S6.02
Hydrophobic TM6 E 247 6x29 S6 R 72 N.S6.02
Van-der-waals TM6 E 247 6x29 S6 R 72 N.S6.02
Hydrophobic ICL2 L 144 34x51 S9 C 137 N.S9.01
Hydrophobic TM2 K 71 2x37 s5s6 V 66 N.s5s6.07
Polar TM6 K 250 6x32 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 K 250 6x32 s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 R 145 34x52 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 R 145 34x52 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 T 148 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 T 148 34x55 S16 D 244 C.S16.01
Polar TM6 T 254 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 254 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 254 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 254 6x36 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 144 34x51 s15s16 L 240 C.s15s16.02
Van-der-waals ICL2 L 144 34x51 s15s16 L 240 C.s15s16.02
Polar ICL2 L 144 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 144 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 144 34x51 s15s16 S 242 C.s15s16.04
Polar ICL2 T 147 34x54 S5 Y 59 N.S5.12
Ionic ICL2 R 145 34x52 s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 R 145 34x52 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 R 145 34x52 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 L 144 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 144 34x51 S5 Y 59 N.S5.12