S-arrestin - OR51I2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OR51I2 82.0
S-arrestin 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 130 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 130 34x51 S15 V 251 C.S15.14
Hydrophobic TM3 I 126 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 126 3x54 S6 F 83 N.S6.01
Hydrophobic ICL2 T 134 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 134 34x55 s8s9 K 145 N.s8s9.09
Polar TM6 T 240 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 240 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 240 6x36 s5s6 I 79 N.s5s6.08
Polar ICL2 P 129 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 129 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 129 34x50 S5 Y 71 N.S5.12
Polar ICL2 R 131 34x52 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 R 131 34x52 s15s16 S 256 C.s15s16.05
Ionic TM6 K 236 6x32 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 Y 132 34x53 s5s6 I 79 N.s5s6.08
Polar TM6 E 233 6x29 S6 D 86 N.S6.04
Hydrophobic H8 E 298 8x49 s5s6 V 78 N.s5s6.07
Van-der-waals H8 E 298 8x49 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 E 233 6x29 S6 R 84 N.S6.02
Van-der-waals TM6 E 233 6x29 S6 R 84 N.S6.02
Hydrophobic TM2 Y 60 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 Y 60 2x40 s5s6 V 78 N.s5s6.07
Polar TM6 K 236 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 236 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 236 6x32 s5s6 G 80 N.s5s6.09
Polar TM6 K 236 6x32 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 K 236 6x32 s5s6 T 82 N.s5s6.11
Hydrophobic ICL2 L 130 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 P 129 34x50 S6 F 83 N.S6.01
Van-der-waals ICL2 P 129 34x50 S6 F 83 N.S6.01
Hydrophobic ICL2 P 129 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 129 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 I 126 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 126 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 R 131 34x52 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 R 131 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic TM2 E 57 2x37 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 A 125 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 125 3x53 S6 F 83 N.S6.01
Hydrophobic TM2 M 59 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 M 59 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 D 128 3x56 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 D 128 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 L 130 34x51 s15s16 L 253 C.s15s16.02
Van-der-waals ICL2 L 130 34x51 s15s16 L 253 C.s15s16.02
Hydrophobic TM3 A 125 3x53 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 A 125 3x53 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 130 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 130 34x51 s15s16 S 255 C.s15s16.04
Polar TM6 E 232 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 E 232 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 E 232 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 L 130 34x51 S5 F 69 N.S5.10
Polar ICL2 L 130 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 130 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 130 34x51 S5 Y 71 N.S5.12
Polar ICL2 A 133 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 133 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 133 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 E 233 6x29 S6 R 85 N.S6.03
Hydrophobic TM6 A 237 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 237 6x33 s5s6 L 81 N.s5s6.10
Ionic ICL2 R 131 34x52 S16 D 257 C.S16.01
Polar ICL2 R 131 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 R 131 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 R 131 34x52 S16 D 257 C.S16.01
Polar TM2 E 57 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 M 59 2x39 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 130 34x51 S9 C 147 N.S9.01