Beta-arrestin-2 - OR51M1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OR51M1 77.7
Beta-arrestin-2 77.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 L 142 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 142 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 142 34x51 S5 Y 64 N.S5.12
Polar ICL2 S 145 34x54 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 S 145 34x54 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 S 145 34x54 s8s9 G 138 N.s8s9.08
Hydrophobic TM3 I 138 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 138 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 142 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 142 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 I 138 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 138 3x54 S6 F 76 N.S6.01
Hydrophobic TM3 A 137 3x53 S6 F 76 N.S6.01
Van-der-waals TM3 A 137 3x53 S6 F 76 N.S6.01
Polar ICL2 L 142 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 L 142 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 142 34x51 s15s16 S 246 C.s15s16.04
Polar TM6 T 252 6x36 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 252 6x36 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 T 252 6x36 s5s6 L 74 N.s5s6.10
Polar ICL2 L 142 34x51 S16 Y 250 C.S16.03
Hydrophobic TM3 H 140 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 A 137 3x53 s5s6 L 74 N.s5s6.10
Polar ICL1 R 66 12x49 s20c Q 407 C.s20c.17
Hydrophobic ICL1 R 66 12x49 s20c Q 407 C.s20c.17
Van-der-waals ICL1 R 66 12x49 s20c Q 407 C.s20c.17
Polar H8 E 310 8x49 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 E 245 6x29 S6 R 77 N.S6.02
Hydrophobic TM5 L 240 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 L 142 34x51 s15s16 F 245 C.s15s16.03
Polar TM6 T 252 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 252 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 252 6x36 s5s6 L 72 N.s5s6.08
Polar ICL2 P 141 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 141 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 141 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 Y 144 34x53 s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 Y 144 34x53 s8s9 K 139 N.s8s9.09
Hydrophobic TM4 T 149 4x38 s8s9 T 137 N.s8s9.07
Van-der-waals TM4 T 149 4x38 s8s9 T 137 N.s8s9.07
Polar ICL2 R 143 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 R 143 34x52 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 R 143 34x52 s15s16 S 246 C.s15s16.04
Polar H8 E 310 8x49 s5s6 L 72 N.s5s6.08
Hydrophobic H8 E 310 8x49 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 142 34x51 S16 A 248 C.S16.01
Hydrophobic TM2 M 71 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 Y 72 2x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 142 34x51 S5 F 62 N.S5.10
Hydrophobic TM6 A 249 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 249 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic H8 E 310 8x49 s5s6 V 71 N.s5s6.07
Van-der-waals H8 E 310 8x49 s5s6 V 71 N.s5s6.07
Polar TM2 Y 72 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 Y 72 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 Y 72 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 142 34x51 s15s16 L 244 C.s15s16.02
Van-der-waals ICL2 L 142 34x51 s15s16 L 244 C.s15s16.02
Polar ICL2 S 145 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 S 145 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 S 145 34x54 s8s9 T 137 N.s8s9.07
Polar ICL2 S 145 34x54 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 P 141 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 P 141 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 R 143 34x52 S16 A 248 C.S16.01
Polar ICL2 V 146 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 V 146 34x55 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 V 146 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 L 240 5x68 S6 F 76 N.S6.01
Polar TM6 E 245 6x29 S6 K 78 N.S6.03
Polar TM6 R 248 6x32 s5s6 S 75 N.s5s6.11
Hydrophobic ICL1 L 67 12x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 P 141 34x50 S6 F 76 N.S6.01
Van-der-waals ICL2 P 141 34x50 S6 F 76 N.S6.01