Arrestin-C - OR51S1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OR51S1 78.2
Arrestin-C 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 134 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 134 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 H 139 34x52 s15s16 Y 241 C.s15s16.03
Aromatic ICL2 H 139 34x52 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 H 139 34x52 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 P 141 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 141 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 A 142 34x55 s15s16 S 242 C.s15s16.04
Hydrophobic H8 M 303 8x47 s5s6 V 66 N.s5s6.07
Polar TM2 R 65 2x37 s8s9 A 133 N.s8s9.07
Van-der-waals TM2 R 65 2x37 s8s9 A 133 N.s8s9.07
Polar TM6 T 247 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 247 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 247 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 R 65 2x37 s8s9 K 135 N.s8s9.09
Van-der-waals TM2 R 65 2x37 s8s9 K 135 N.s8s9.09
Ionic H8 E 305 8x49 s5s6 R 61 N.s5s6.02
Polar H8 E 305 8x49 s5s6 R 61 N.s5s6.02
Van-der-waals H8 E 305 8x49 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 L 138 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 L 138 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic H8 E 305 8x49 s5s6 D 63 N.s5s6.04
Van-der-waals H8 E 305 8x49 s5s6 D 63 N.s5s6.04
Polar ICL2 L 138 34x51 s15s16 S 242 C.s15s16.04
Polar TM2 R 65 2x37 s8s9 G 134 N.s8s9.08
Van-der-waals TM2 R 65 2x37 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 L 138 34x51 S6 F 71 N.S6.01
Hydrophobic TM2 M 67 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 A 142 34x55 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 A 142 34x55 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 A 133 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 133 3x53 S6 F 71 N.S6.01
Hydrophobic TM6 K 243 6x32 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 K 243 6x32 s5s6 G 68 N.s5s6.09
Polar TM6 T 247 6x36 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 T 247 6x36 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 T 247 6x36 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 L 138 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 138 34x51 S5 Y 59 N.S5.12
Hydrophobic TM3 A 133 3x53 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 A 133 3x53 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 L 232 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 138 34x51 S6 K 73 N.S6.03
Hydrophobic TM6 A 244 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 V 235 5x68 s5s6 L 69 N.s5s6.10
Ionic TM6 E 239 6x28 s9s10 K 157 N.s9s10.12
Polar TM6 E 239 6x28 s9s10 K 157 N.s9s10.12
Van-der-waals TM6 E 239 6x28 s9s10 K 157 N.s9s10.12
Polar TM6 A 244 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 A 244 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 244 6x33 s5s6 I 67 N.s5s6.08
Ionic H8 K 304 8x48 s5s6 E 65 N.s5s6.06
Polar H8 K 304 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 K 304 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic ICL3 E 236 - s9s10 T 154 N.s9s10.09
Hydrophobic ICL2 P 137 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 P 137 34x50 S6 F 71 N.S6.01
Hydrophobic ICL2 P 141 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 141 34x54 S5 Y 59 N.S5.12
Polar ICL1 A 62 12x49 s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 A 62 12x49 s5s6 R 61 N.s5s6.02
Hydrophobic TM2 R 65 2x37 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 R 65 2x37 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 R 130 3x50 s5s6 I 67 N.s5s6.08
Polar TM6 T 247 6x36 s5s6 G 68 N.s5s6.09
Polar TM6 D 240 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 L 138 34x51 S5 F 57 N.S5.10
Van-der-waals ICL2 L 138 34x51 S5 F 57 N.S5.10
Hydrophobic TM6 K 243 6x32 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 134 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 134 3x54 s5s6 I 67 N.s5s6.08