Beta-arrestin-1 - GPR68 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR68 74.4
Beta-arrestin-1 78.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 S 290 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 G 217 - S6 K 77 N.S6.03
Van-der-waals ICL3 G 217 - S6 K 77 N.S6.03
Hydrophobic TM5 V 212 5x65 S6 F 75 N.S6.01
Hydrophobic TM2 L 56 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 L 56 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 119 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 119 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 A 211 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 A 122 3x53 s5s6 L 68 N.s5s6.05
Polar ICL2 R 128 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 128 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 V 123 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 123 3x54 S6 F 75 N.S6.01
Hydrophobic TM3 V 123 3x54 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 V 123 3x54 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 V 212 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM4 T 134 4x38 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 T 134 4x38 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 H 216 - S6 K 77 N.S6.03
Hydrophobic TM3 V 123 3x54 s5s6 L 73 N.s5s6.10
Polar TM3 H 125 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 H 125 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 H 125 3x56 s15s16 N 245 C.s15s16.04
Ionic H8 R 299 8x56 s20c E 407 C.s20c.17
Polar H8 R 299 8x56 s20c E 407 C.s20c.17
Hydrophobic H8 R 299 8x56 s20c E 407 C.s20c.17
Van-der-waals H8 R 299 8x56 s20c E 407 C.s20c.17
Hydrophobic ICL2 F 127 34x51 s8s9 G 137 N.s8s9.08
Hydrophobic ICL3 S 215 - S6 F 75 N.S6.01
Van-der-waals ICL3 S 215 - S6 F 75 N.S6.01
Ionic ICL2 H 130 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 H 130 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 H 130 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 H 130 34x54 s8s9 D 135 N.s8s9.06
Polar H8 E 291 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 E 291 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 E 291 8x48 s5s6 D 69 N.s5s6.06
Ionic TM2 E 55 2x38 s8s9 K 138 N.s8s9.09
Polar ICL2 R 133 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 133 34x57 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 133 34x57 s8s9 T 136 N.s8s9.07
Polar ICL3 G 217 - S6 D 78 N.S6.04
Hydrophobic ICL3 G 217 - S6 D 78 N.S6.04
Van-der-waals ICL3 G 217 - S6 D 78 N.S6.04
Van-der-waals ICL2 P 126 34x50 s8s9 G 137 N.s8s9.08
Polar TM6 Q 219 6x26 S6 D 78 N.S6.04
Van-der-waals TM6 Q 219 6x26 S6 D 78 N.S6.04
Polar ICL2 P 126 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 126 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 126 34x50 S5 Y 63 N.S5.12
Polar TM3 R 119 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 119 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 119 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 V 230 6x37 s5s6 L 71 N.s5s6.08
Polar TM6 R 222 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic H8 S 290 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 290 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 Y 205 5x58 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 Y 286 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 F 127 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 F 127 34x51 S16 A 247 C.S16.01
Hydrophobic TM3 V 123 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 R 133 34x57 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 R 133 34x57 s8s9 K 138 N.s8s9.09
Hydrophobic H8 T 292 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 F 127 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 F 127 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 I 208 5x61 s5s6 L 73 N.s5s6.10
Polar TM2 N 54 2x37 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 N 54 2x37 s5s6 R 65 N.s5s6.02
Polar ICL1 R 53 12x51 s5s6 R 65 N.s5s6.02
Hydrophobic ICL1 R 53 12x51 s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 R 53 12x51 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 F 127 34x51 S9 C 140 N.S9.01
Polar ICL2 R 128 34x52 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 R 128 34x52 s15s16 T 246 C.s15s16.05
Polar TM2 N 54 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 F 127 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 F 127 34x51 S15 I 241 C.S15.14
Hydrophobic TM6 L 229 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 229 6x36 s5s6 L 71 N.s5s6.08
Polar H8 T 292 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 T 292 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 T 292 8x49 s5s6 D 69 N.s5s6.06
Ionic TM2 E 55 2x38 s5s6 R 65 N.s5s6.02
Polar TM2 E 55 2x38 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 E 55 2x38 s5s6 R 65 N.s5s6.02
Hydrophobic H8 T 292 8x49 s5s6 D 67 N.s5s6.04
Polar ICL2 H 130 34x54 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 H 130 34x54 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 H 130 34x54 s8s9 E 134 N.s8s9.05
Polar ICL3 T 218 - S6 R 76 N.S6.02
Hydrophobic ICL3 T 218 - S6 R 76 N.S6.02
Van-der-waals ICL3 T 218 - S6 R 76 N.S6.02
Hydrophobic TM5 I 208 5x61 s5s6 L 71 N.s5s6.08
Polar ICL2 H 130 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 H 130 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 H 130 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 F 127 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 F 127 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL3 G 217 - S6 R 76 N.S6.02
Van-der-waals ICL3 G 217 - S6 R 76 N.S6.02
Polar TM6 R 222 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 R 222 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 R 222 6x29 s5s6 G 72 N.s5s6.09
Ionic H8 R 295 8x52 s5s6 E 66 N.s5s6.03
Polar H8 R 295 8x52 s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 P 126 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 126 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 126 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 126 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 I 226 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 I 226 6x33 s5s6 L 73 N.s5s6.10
Aromatic ICL2 F 127 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 F 127 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 F 127 34x51 S5 Y 63 N.S5.12