Beta-arrestin-2 - OPN4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OPN4 62.6
Beta-arrestin-2 77.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM7 Y 350 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 171 3x53 s5s6 R 66 N.s5s6.02
Ionic H8 K 356 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 356 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 356 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 356 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 I 172 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 L 282 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 L 282 - s9s10 L 155 N.s9s10.03
Polar ICL2 T 178 34x53 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 176 34x51 s15s16 T 247 C.s15s16.05
Polar TM7 T 353 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 T 353 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 T 353 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 176 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 176 34x51 S16 A 248 C.S16.01
Hydrophobic TM3 I 172 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 172 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM2 T 103 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 175 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM7 T 353 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 C 275 5x78 S6 F 81 N.S6.06
Van-der-waals TM5 C 275 5x78 S6 F 81 N.S6.06
Polar H8 H 354 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 H 354 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 H 354 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 P 175 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 175 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 175 34x50 S5 Y 64 N.S5.12
Polar TM7 T 353 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic ICL3 L 282 - s9s10 E 156 N.s9s10.07
Hydrophobic TM5 I 258 5x61 s5s6 L 74 N.s5s6.10
Polar ICL2 T 178 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 T 178 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 F 179 34x54 S8 L 130 N.S8.03
Hydrophobic ICL3 W 283 - S6 I 82 N.S6.07
Hydrophobic ICL2 G 180 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 I 262 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 262 5x65 s5s6 L 74 N.s5s6.10
Polar H8 H 354 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 H 354 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 H 354 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 F 179 34x54 S9 C 141 N.S9.01
Polar ICL2 A 182 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 182 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 182 34x57 s5s6 R 66 N.s5s6.02
Aromatic ICL2 F 179 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 176 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 176 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL1 S 100 12x49 s20c Y 404 C.s20c.14
Polar TM5 A 268 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 A 268 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 A 268 5x71 S6 K 78 N.S6.03
Ionic TM4 K 184 4x39 s8s9 E 135 N.s8s9.05
Polar TM4 K 184 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 184 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 184 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 I 297 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic H8 K 356 8x49 s20c L 408 C.s20c.18
Van-der-waals H8 K 356 8x49 s20c L 408 C.s20c.18
Hydrophobic TM3 R 168 3x50 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 R 168 3x50 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 L 269 5x72 S6 D 79 N.S6.04
Van-der-waals TM5 L 269 5x72 S6 D 79 N.S6.04
Hydrophobic ICL2 L 176 34x51 S5 Y 64 N.S5.12
Hydrophobic H8 P 355 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 P 355 8x48 s5s6 D 70 N.s5s6.06
Aromatic ICL2 F 179 34x54 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 179 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 179 34x54 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 179 34x54 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 F 179 34x54 s8s9 A 140 N.s8s9.10
Polar TM6 K 293 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM5 F 272 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 F 272 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 F 272 5x75 s15s16 L 244 C.s15s16.02
Ionic TM3 R 168 3x50 s5s6 D 68 N.s5s6.04
Polar TM3 R 168 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 168 3x50 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 168 3x50 s5s6 D 68 N.s5s6.04
Polar TM2 T 103 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 103 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 103 2x37 s5s6 D 68 N.s5s6.04
Polar TM5 G 273 5x76 S6 L 80 N.S6.05
Hydrophobic TM3 I 172 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 172 3x54 S6 F 76 N.S6.01
Hydrophobic TM5 Y 255 5x58 s5s6 L 72 N.s5s6.08
Polar ICL2 L 176 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 176 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 176 34x51 S16 Y 250 C.S16.03
Hydrophobic TM3 R 168 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 168 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 N 106 2x40 s5s6 D 68 N.s5s6.04
Ionic TM6 R 285 6x24 s9s10 E 156 N.s9s10.07
Polar TM6 R 285 6x24 s9s10 E 156 N.s9s10.07
Van-der-waals TM6 R 285 6x24 s9s10 E 156 N.s9s10.07
Hydrophobic ICL2 F 179 34x54 s8s9 Q 131 N.s8s9.01
Hydrophobic TM5 F 272 5x75 S6 L 80 N.S6.05
Hydrophobic ICL2 L 176 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 176 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 V 171 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 F 272 5x75 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 F 272 5x75 s17s18 E 314 C.s17s18.39
Hydrophobic C-term Y 382 - s1s2 P 15 N.s1s2.02
Hydrophobic TM2 I 109 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 I 109 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 M 294 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 M 294 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 I 262 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 I 262 5x65 S6 F 76 N.S6.01
Polar TM2 A 105 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 A 105 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 A 105 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM7 T 353 7x56 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 F 179 34x54 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 179 34x54 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 F 179 34x54 s17s18 G 287 C.s17s18.12
Hydrophobic TM3 V 171 3x53 S5 Y 64 N.S5.12
Hydrophobic C-term Y 382 - s20c Q 407 C.s20c.17
Hydrophobic ICL3 W 283 - S6 D 79 N.S6.04
Hydrophobic C-term H 378 - s9s10 K 161 N.s9s10.12
Hydrophobic TM5 T 265 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 T 265 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 L 269 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 L 269 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 F 272 5x75 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 F 272 5x75 s17s18 V 315 C.s17s18.40