Beta-arrestin-2 - OPN5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OPN5 73.6
Beta-arrestin-2 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 G 141 34x53 s5s6 E 67 N.s5s6.03
Van-der-waals ICL2 G 141 34x53 s5s6 E 67 N.s5s6.03
Polar ICL3 D 237 - S6 R 77 N.S6.02
Hydrophobic ICL3 D 237 - S6 R 77 N.S6.02
Van-der-waals ICL3 D 237 - S6 R 77 N.S6.02
Van-der-waals ICL3 F 236 - S6 R 77 N.S6.02
Polar TM6 E 247 6x30 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 E 247 6x30 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 E 247 6x30 s5s6 D 70 N.s5s6.06
Ionic TM6 H 244 6x27 s5s6 D 70 N.s5s6.06
Polar TM6 H 244 6x27 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 H 244 6x27 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 H 244 6x27 s5s6 D 70 N.s5s6.06
Polar TM6 T 251 6x34 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 251 6x34 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 251 6x34 s5s6 V 71 N.s5s6.07
Polar TM6 H 244 6x27 S6 F 76 N.S6.01
Polar TM6 H 241 6x24 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 H 241 6x24 s5s6 G 73 N.s5s6.09
Polar TM6 H 241 6x24 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 H 241 6x24 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 H 241 6x24 s5s6 S 75 N.s5s6.11
Hydrophobic TM5 V 226 5x65 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 V 226 5x65 s5s6 L 72 N.s5s6.08
Polar ICL2 V 142 34x54 s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 V 142 34x54 s5s6 E 67 N.s5s6.03
Van-der-waals ICL2 V 142 34x54 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 M 248 6x31 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 M 248 6x31 s5s6 L 74 N.s5s6.10
Polar TM6 H 244 6x27 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 H 244 6x27 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 H 244 6x27 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 T 251 6x34 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 251 6x34 s5s6 L 72 N.s5s6.08
Polar TM6 M 248 6x31 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 M 248 6x31 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 M 248 6x31 s5s6 V 71 N.s5s6.07
Hydrophobic C-term F 332 - S20 D 390 C.S20.05
Van-der-waals C-term F 332 - S20 D 390 C.S20.05
Hydrophobic TM6 R 239 6x22 S6 R 77 N.S6.02
Van-der-waals TM6 R 239 6x22 S6 R 77 N.S6.02
Polar TM5 S 229 5x68 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 F 236 - s15s16 L 244 C.s15s16.02
Van-der-waals ICL3 F 236 - s15s16 L 244 C.s15s16.02
Hydrophobic TM3 K 134 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 I 135 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 V 142 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 V 142 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 138 34x50 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 L 138 34x50 s5s6 D 68 N.s5s6.04
Polar TM6 I 240 6x23 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 I 240 6x23 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 I 240 6x23 s5s6 S 75 N.s5s6.11
Polar TM6 S 243 6x26 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 S 243 6x26 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 S 243 6x26 s5s6 D 70 N.s5s6.06
Ionic TM6 R 239 6x22 S6 D 79 N.S6.04
Polar TM6 R 239 6x22 S6 D 79 N.S6.04
Hydrophobic TM6 R 239 6x22 S6 D 79 N.S6.04
Van-der-waals TM6 R 239 6x22 S6 D 79 N.S6.04
Hydrophobic TM3 R 131 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 131 3x50 s5s6 V 71 N.s5s6.07
Polar TM6 E 247 6x30 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 E 247 6x30 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 E 247 6x30 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 M 248 6x31 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 248 6x31 s5s6 L 72 N.s5s6.08
Polar TM6 H 244 6x27 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 H 244 6x27 s5s6 L 69 N.s5s6.05
Van-der-waals TM6 H 244 6x27 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 I 240 6x23 S6 R 77 N.S6.02
Van-der-waals TM6 I 240 6x23 S6 R 77 N.S6.02
Hydrophobic TM5 I 222 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 135 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 F 236 - S6 K 78 N.S6.03
Van-der-waals ICL3 F 236 - S6 K 78 N.S6.03
Ionic TM4 K 145 4x38 s8s9 E 135 N.s8s9.05
Polar TM4 K 145 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 145 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 145 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 V 142 34x54 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 V 142 34x54 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 F 236 - S6 F 76 N.S6.01
Polar ICL1 R 66 12x51 s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 66 12x51 s20c Y 404 C.s20c.14
Hydrophobic TM6 H 244 6x27 s5s6 G 65 N.s5s6.01
Polar TM6 H 244 6x27 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 H 244 6x27 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 H 244 6x27 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 V 142 34x54 s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 V 142 34x54 s8s9 P 134 N.s8s9.04
Hydrophobic ICL2 L 138 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 138 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 I 135 3x54 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 I 135 3x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 M 248 6x31 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 M 248 6x31 s5s6 G 73 N.s5s6.09
Polar ICL2 L 138 34x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 138 34x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 L 138 34x50 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 E 247 6x30 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 E 247 6x30 s5s6 V 71 N.s5s6.07
Polar TM6 H 244 6x27 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 H 244 6x27 s5s6 L 72 N.s5s6.08
Polar TM6 V 245 6x28 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 V 245 6x28 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 V 245 6x28 s5s6 G 73 N.s5s6.09
Polar ICL3 S 238 - S6 R 77 N.S6.02
Hydrophobic ICL3 S 238 - S6 R 77 N.S6.02
Polar TM6 H 244 6x27 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 H 244 6x27 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 H 244 6x27 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 I 240 6x23 s20c L 408 C.s20c.18
Hydrophobic TM5 V 226 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 L 250 6x33 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 V 233 5x72 S6 F 76 N.S6.01
Van-der-waals TM5 V 233 5x72 S6 F 76 N.S6.01
Ionic TM6 E 247 6x30 s8s9 K 139 N.s8s9.09
Polar TM6 E 247 6x30 s8s9 K 139 N.s8s9.09
Hydrophobic TM6 I 240 6x23 S5 R 63 N.S5.11
Van-der-waals TM6 I 240 6x23 S5 R 63 N.S5.11
Hydrophobic ICL2 S 139 34x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 S 139 34x51 s8s9 T 137 N.s8s9.07
Polar TM6 M 248 6x31 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 M 248 6x31 s5s6 D 70 N.s5s6.06
Hydrophobic C-term L 334 - S20 V 387 C.S20.02
Hydrophobic TM5 S 229 5x68 s5s6 L 69 N.s5s6.05
Aromatic ICL3 F 236 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 F 236 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 F 236 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 V 142 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 V 142 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL3 D 237 - S6 D 79 N.S6.04
Polar C-term T 339 - s19s20 D 385 C.s19s20.51
Hydrophobic C-term T 339 - s19s20 D 385 C.s19s20.51
Van-der-waals C-term T 339 - s19s20 D 385 C.s19s20.51
Polar TM3 K 134 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 K 134 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 K 134 3x53 s5s6 D 68 N.s5s6.04