Arrestin-C - δ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
δ 75.3
Arrestin-C 81.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 239 5x64 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 R 239 5x64 s15s16 S 242 C.s15s16.04
Hydrophobic TM6 V 263 6x37 s5s6 I 67 N.s5s6.08
Polar TM3 H 152 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 H 152 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 P 153 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 153 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 V 154 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 V 154 34x51 S8 L 126 N.S8.03
Ionic TM6 K 252 6x26 S6 D 74 N.S6.04
Polar TM6 K 252 6x26 S6 D 74 N.S6.04
Hydrophobic TM6 K 252 6x26 S6 D 74 N.S6.04
Van-der-waals TM6 K 252 6x26 S6 D 74 N.S6.04
Hydrophobic H8 D 322 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 D 322 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 L 157 34x54 S8 L 126 N.S8.03
Ionic ICL2 R 160 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 160 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 160 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 160 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 84 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 84 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 I 259 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 I 259 6x33 s5s6 I 67 N.s5s6.08
Polar ICL2 K 155 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 K 155 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 K 155 34x52 S16 Y 246 C.S16.03
Ionic H8 K 335 8x60 s20c E 386 C.s20c.20
Polar H8 K 335 8x60 s20c E 386 C.s20c.20
Hydrophobic H8 K 335 8x60 s20c E 386 C.s20c.20
Van-der-waals H8 K 335 8x60 s20c E 386 C.s20c.20
Polar ICL2 R 160 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 160 34x57 s5s6 R 61 N.s5s6.02
Polar H8 Q 331 8x56 s20c E 386 C.s20c.20
Polar ICL2 L 157 34x54 s17s18 R 282 C.s17s18.11
Polar ICL2 V 154 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 V 154 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 V 154 34x51 S16 Y 246 C.S16.03
Ionic ICL2 D 158 34x55 S16 K 248 C.S16.05
Polar ICL2 D 158 34x55 S16 K 248 C.S16.05
Van-der-waals ICL2 D 158 34x55 S16 K 248 C.S16.05
Polar TM3 R 146 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 146 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 L 157 34x54 s5s6 R 61 N.s5s6.02
Polar TM6 K 252 6x26 S6 R 72 N.S6.02
Van-der-waals TM6 K 252 6x26 S6 R 72 N.S6.02
Polar TM5 R 239 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 239 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 239 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 I 259 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 I 259 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM4 T 161 4x38 s17s18 R 282 C.s17s18.11
Van-der-waals TM4 T 161 4x38 s17s18 R 282 C.s17s18.11
Hydrophobic TM5 L 240 5x65 S6 F 71 N.S6.01
Van-der-waals TM5 L 240 5x65 S6 F 71 N.S6.01
Polar H8 N 324 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 324 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 324 8x49 s5s6 E 65 N.s5s6.06
Ionic H8 R 327 8x52 s5s6 E 65 N.s5s6.06
Polar H8 R 327 8x52 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 327 8x52 s5s6 E 65 N.s5s6.06
Hydrophobic TM5 L 240 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 153 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 153 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 A 149 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 149 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM2 I 88 2x43 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 146 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 146 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 V 154 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 V 154 34x51 S15 V 238 C.S15.14
Hydrophobic ICL2 R 160 34x57 s5s6 L 64 N.s5s6.05
Ionic TM3 H 152 3x56 S16 D 244 C.S16.01
Polar TM3 H 152 3x56 S16 D 244 C.S16.01
Hydrophobic TM3 H 152 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 H 152 3x56 S16 D 244 C.S16.01
Hydrophobic TM5 M 236 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 T 82 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 82 2x37 s5s6 D 63 N.s5s6.04
Polar TM3 V 150 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 V 150 3x54 S5 Y 59 N.S5.12
Van-der-waals TM3 V 150 3x54 S5 Y 59 N.S5.12
Polar TM3 C 151 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 C 151 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 C 151 3x55 s15s16 S 242 C.s15s16.04
Polar H8 D 322 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 D 322 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 D 322 8x47 s5s6 V 66 N.s5s6.07
Polar H8 R 334 8x59 s20c S 388 C.s20c.22
Van-der-waals H8 R 334 8x59 s20c S 388 C.s20c.22
Ionic ICL2 K 155 34x52 S16 D 244 C.S16.01
Polar ICL2 K 155 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 K 155 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 K 155 34x52 S16 D 244 C.S16.01
Hydrophobic ICL3 L 246 - S6 K 73 N.S6.03
Van-der-waals ICL3 L 246 - S6 K 73 N.S6.03
Hydrophobic TM5 V 243 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 V 243 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 V 150 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 V 154 34x51 S9 C 137 N.S9.01
Polar H8 E 323 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 A 149 3x53 S5 Y 59 N.S5.12
Van-der-waals TM3 A 149 3x53 S5 Y 59 N.S5.12
Hydrophobic TM3 V 150 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 V 150 3x54 S6 F 71 N.S6.01
Hydrophobic TM6 M 262 6x36 s5s6 I 67 N.s5s6.08