Gz - δ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-05-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
δ 75.5
Gαz 88.2
Gβ1 94.4
Gγ2 76.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 28.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 154 34x51 G.s2s3 E 194 G.s2s3.02
Ionic TM5 R 239 5x64 G.H5 D 342 G.H5.13
Polar TM5 R 239 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 239 5x64 G.H5 D 342 G.H5.13
Hydrophobic TM5 M 236 5x61 G.H5 L 354 G.H5.25
Hydrophobic ICL2 V 154 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM6 I 259 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 259 6x33 G.H5 L 354 G.H5.25
Ionic ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 E 251 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 E 251 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 M 262 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM6 M 262 6x36 G.H5 G 353 G.H5.24
Ionic TM6 K 252 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 252 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 K 252 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 K 252 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 V 154 34x51 G.S3 L 195 G.S3.01
Polar TM2 T 84 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 T 84 2x39 G.H5 Y 351 G.H5.22
Hydrophobic ICL3 R 244 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 244 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 L 245 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 L 245 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 L 245 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 V 150 3x54 G.H5 L 349 G.H5.20
Polar TM3 R 146 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM5 R 239 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 239 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM3 A 149 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 149 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM5 V 243 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM2 T 84 2x39 G.H5 I 352 G.H5.23
Hydrophobic ICL3 L 245 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 L 245 - G.H5 Q 346 G.H5.17
Hydrophobic TM3 V 150 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 V 150 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 R 160 34x57 G.H5 I 352 G.H5.23
Van-der-waals ICL2 R 160 34x57 G.H5 I 352 G.H5.23
Polar ICL3 R 244 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 244 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 L 157 34x54 G.H5 I 344 G.H5.15
Polar ICL2 R 160 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 160 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic ICL3 L 246 - G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Polar ICL2 R 160 34x57 G.H5 N 348 G.H5.19
Van-der-waals ICL2 R 160 34x57 G.H5 N 348 G.H5.19
Hydrophobic TM6 M 262 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 153 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM5 L 240 5x65 G.H5 L 349 G.H5.20
Polar ICL2 L 157 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 157 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 L 157 34x54 G.hns1 R 31 G.hns1.02
Polar TM3 A 149 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 153 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM6 V 263 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 V 243 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 P 153 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 153 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM4 T 161 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 161 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 157 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 157 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL3 L 245 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 L 245 - G.S6 Y 321 G.S6.02
Polar C-term E 355 - G.H3 W 259 G.H3.17
Hydrophobic C-term E 355 - G.H3 W 259 G.H3.17
Van-der-waals C-term E 355 - G.H3 W 259 G.H3.17
Hydrophobic TM3 R 146 3x50 G.H5 L 354 G.H5.25
Polar C-term T 358 - G.H3 N 258 G.H3.16
Polar ICL3 L 245 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 L 245 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 L 245 - G.H5 D 342 G.H5.13
Hydrophobic TM6 I 259 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 I 259 6x33 G.H5 C 355 G.H5.26
Hydrophobic C-term E 355 - G.H3 N 258 G.H3.16
Polar C-term E 355 - G.H3 N 258 G.H3.16
Van-der-waals C-term E 355 - G.H3 N 258 G.H3.16
Hydrophobic ICL3 R 244 - G.S6 Y 321 G.S6.02
Hydrophobic TM5 L 240 5x65 G.H5 I 345 G.H5.16
Hydrophobic ICL3 L 245 - G.H5 V 343 G.H5.14
Hydrophobic C-term A 372 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term A 372 - G.s4h3 E 237 G.s4h3.10
Polar C-term A 372 - G.s4h3 E 237 G.s4h3.10
Hydrophobic TM6 I 259 6x33 G.H5 L 349 G.H5.20
Hydrophobic C-term A 370 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term A 370 - G.s4h3 D 238 G.s4h3.11
Hydrophobic C-term A 372 - G.s4h3 L 235 G.s4h3.08
Polar C-term A 371 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term A 371 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term A 371 - G.s4h3 E 237 G.s4h3.10
Polar C-term R 354 - G.H3 N 258 G.H3.16
Hydrophobic C-term R 354 - G.H3 N 258 G.H3.16
Van-der-waals C-term R 354 - G.H3 N 258 G.H3.16
Van-der-waals C-term R 354 - G.h3s5 I 261 G.h3s5.01
Hydrophobic C-term R 354 - G.h3s5 I 261 G.h3s5.01
Hydrophobic C-term A 371 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term A 371 - G.s4h3 D 238 G.s4h3.11
Polar C-term A 371 - G.s4h3 D 238 G.s4h3.11
Hydrophobic H8 D 322 8x47 G.H5 G 353 G.H5.24
Hydrophobic C-term A 372 - G.s4h3 Y 236 G.s4h3.09
Van-der-waals C-term A 372 - G.s4h3 Y 236 G.s4h3.09
Hydrophobic C-term A 371 - G.s4h3 N 239 G.s4h3.12
Van-der-waals C-term A 371 - G.s4h3 N 239 G.s4h3.12
Hydrophobic C-term A 371 - G.s4h3 Q 240 G.s4h3.13
Van-der-waals C-term A 371 - G.s4h3 Q 240 G.s4h3.13
Polar C-term A 370 - G.s4h3 Q 240 G.s4h3.13
Hydrophobic C-term A 370 - G.s4h3 Q 240 G.s4h3.13
Van-der-waals C-term A 370 - G.s4h3 Q 240 G.s4h3.13
Polar C-term A 372 - G.s4h3 D 238 G.s4h3.11
Hydrophobic C-term A 372 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term A 372 - G.s4h3 D 238 G.s4h3.11
Polar C-term A 372 - G.s4h3 N 239 G.s4h3.12
Hydrophobic C-term A 372 - G.s4h3 N 239 G.s4h3.12
Van-der-waals C-term A 372 - G.s4h3 N 239 G.s4h3.12
Hydrophobic C-term G 369 - G.s4h3 Q 240 G.s4h3.13
Van-der-waals C-term G 369 - G.s4h3 Q 240 G.s4h3.13
Hydrophobic TM4 P 162 4x39 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 157 34x54 G.S1 I 34 G.S1.02
Ionic ICL2 K 155 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 K 155 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 K 155 34x52 G.s2s3 E 194 G.s2s3.02
Polar C-term A 351 - G.H3 N 258 G.H3.16
Hydrophobic C-term A 351 - G.H3 N 258 G.H3.16