Beta-arrestin-2 - κ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
κ 72.6
Beta-arrestin-2 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 167 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 167 34x54 S16 Y 250 C.S16.03
Hydrophobic TM2 T 94 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 T 94 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 275 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 T 92 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 92 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 V 256 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 256 5x68 s15s16 F 245 C.s15s16.03
Polar H8 N 336 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 N 336 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 N 336 8x49 s5s6 D 70 N.s5s6.06
Polar H8 D 334 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 D 334 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 D 334 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 A 159 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 159 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 V 164 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 V 164 34x51 S16 A 248 C.S16.01
Polar H8 E 335 8x48 s5s6 D 70 N.s5s6.06
Ionic TM6 K 265 6x26 S6 D 79 N.S6.04
Polar TM6 K 265 6x26 S6 D 79 N.S6.04
Van-der-waals TM6 K 265 6x26 S6 D 79 N.S6.04
Polar ICL2 P 163 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 163 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 163 34x50 S5 Y 64 N.S5.12
Hydrophobic TM3 R 156 3x50 s5s6 L 72 N.s5s6.08
Ionic TM6 E 264 6x25 s9s10 K 158 N.s9s10.09
Polar TM6 E 264 6x25 s9s10 K 158 N.s9s10.09
Hydrophobic TM6 E 264 6x25 s9s10 K 158 N.s9s10.09
Van-der-waals TM6 E 264 6x25 s9s10 K 158 N.s9s10.09
Hydrophobic TM3 V 160 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 V 160 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 L 167 34x54 S5 Y 64 N.S5.12
Hydrophobic TM5 L 253 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 253 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 156 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 156 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 160 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 160 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 163 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 L 253 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 L 253 5x65 S6 F 76 N.S6.01
Polar TM6 N 268 6x29 s5s6 G 73 N.s5s6.09
Ionic ICL1 K 91 12x51 s20c D 402 C.s20c.12
Polar ICL2 A 166 34x53 s5s6 R 66 N.s5s6.02
Polar ICL2 R 170 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 170 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 170 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 M 249 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 M 249 5x61 s5s6 L 72 N.s5s6.08
Polar TM2 T 94 2x39 s5s6 D 68 N.s5s6.04
Polar C-term R 354 - s20c Y 404 C.s20c.14
Van-der-waals C-term R 354 - s20c Y 404 C.s20c.14
Hydrophobic TM5 V 256 5x68 S6 F 76 N.S6.01
Hydrophobic ICL2 V 164 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 V 164 34x51 S15 I 242 C.S15.14
Hydrophobic ICL3 L 259 - s15s16 F 245 C.s15s16.03
Polar TM6 K 265 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 K 265 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 K 265 6x26 S6 R 77 N.S6.02
Polar ICL2 R 170 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 170 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM4 P 172 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 I 272 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 I 272 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 160 3x54 s5s6 L 69 N.s5s6.05
Polar TM5 R 252 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 252 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 252 5x64 s15s16 F 245 C.s15s16.03
Polar ICL2 V 164 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 V 164 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 V 164 34x51 S16 Y 250 C.S16.03
Polar ICL2 L 167 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 167 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 167 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals TM6 L 275 6x36 s5s6 V 71 N.s5s6.07
Polar ICL3 S 260 - S6 R 77 N.S6.02
Polar C-term R 361 - s20c Q 407 C.s20c.17
Hydrophobic C-term R 361 - s20c Q 407 C.s20c.17
Van-der-waals C-term R 361 - s20c Q 407 C.s20c.17
Hydrophobic ICL2 V 164 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 I 272 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 272 6x33 s5s6 L 72 N.s5s6.08