Arrestin-C - μ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
μ 73.0
Arrestin-C 81.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 171 3x54 S6 F 71 N.S6.01
Hydrophobic ICL3 L 267 - S6 K 73 N.S6.03
Hydrophobic TM6 M 283 6x36 s5s6 I 67 N.s5s6.08
Polar H8 N 344 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 344 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 344 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM5 M 257 5x61 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 M 257 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 V 175 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 V 175 34x51 S15 V 238 C.S15.14
Hydrophobic TM2 T 103 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic ICL3 L 267 - s15s16 Y 241 C.s15s16.03
Polar TM4 P 183 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 P 183 4x39 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 P 183 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 L 178 34x54 s17s18 G 283 C.s17s18.12
Polar TM5 R 260 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 260 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 260 5x64 s15s16 Y 241 C.s15s16.03
Polar ICL2 A 177 34x53 s5s6 R 61 N.s5s6.02
Ionic ICL2 K 176 34x52 S16 D 244 C.S16.01
Polar ICL2 K 176 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 K 176 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 K 176 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 V 175 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 V 175 34x51 S8 L 126 N.S8.03
Hydrophobic TM5 V 264 5x68 S6 F 71 N.S6.01
Hydrophobic TM3 H 173 3x56 s15s16 S 242 C.s15s16.04
Polar TM6 N 276 6x29 s5s6 G 68 N.s5s6.09
Polar TM5 R 260 5x64 S5 Y 59 N.S5.12
Van-der-waals TM5 R 260 5x64 S5 Y 59 N.S5.12
Polar TM5 V 264 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 V 264 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 V 264 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 178 34x54 S8 L 126 N.S8.03
Polar H8 D 342 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 D 342 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 D 342 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 D 342 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 D 342 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 P 174 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 174 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 174 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 174 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 L 261 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 261 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM2 T 105 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 105 2x39 s5s6 V 66 N.s5s6.07
Polar ICL2 L 178 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic TM5 L 261 5x65 S6 F 71 N.S6.01
Van-der-waals TM5 L 261 5x65 S6 F 71 N.S6.01
Hydrophobic TM3 A 170 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 170 3x53 s5s6 L 64 N.s5s6.05
Polar H8 E 343 8x48 s5s6 E 65 N.s5s6.06
Polar ICL2 L 178 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 L 178 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 I 280 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 I 280 6x33 s5s6 I 67 N.s5s6.08
Ionic TM6 K 273 6x26 S6 D 74 N.S6.04
Polar TM6 K 273 6x26 S6 D 74 N.S6.04
Van-der-waals TM6 K 273 6x26 S6 D 74 N.S6.04
Ionic TM3 H 173 3x56 S16 D 244 C.S16.01
Polar TM3 H 173 3x56 S16 D 244 C.S16.01
Hydrophobic TM3 H 173 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 H 173 3x56 S16 D 244 C.S16.01
Van-der-waals ICL2 D 179 34x55 s17s18 R 282 C.s17s18.11
Hydrophobic TM6 M 283 6x36 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 M 283 6x36 s5s6 V 66 N.s5s6.07
Polar TM2 T 105 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic H8 E 343 8x48 s5s6 G 68 N.s5s6.09
Ionic H8 R 347 8x52 s5s6 E 65 N.s5s6.06
Polar H8 R 347 8x52 s5s6 E 65 N.s5s6.06
Hydrophobic H8 R 347 8x52 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 347 8x52 s5s6 E 65 N.s5s6.06
Polar TM3 V 171 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 V 171 3x54 S5 Y 59 N.S5.12
Van-der-waals TM3 V 171 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 V 171 3x54 s5s6 L 64 N.s5s6.05
Ionic ICL2 D 179 34x55 S16 K 248 C.S16.05
Polar ICL2 D 179 34x55 S16 K 248 C.S16.05
Van-der-waals ICL2 D 179 34x55 S16 K 248 C.S16.05
Hydrophobic TM6 I 280 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 I 280 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 C 172 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 C 172 3x55 s15s16 S 242 C.s15s16.04
Polar ICL2 K 176 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 K 176 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 K 176 34x52 S16 Y 246 C.S16.03
Hydrophobic TM4 T 182 4x38 s17s18 R 282 C.s17s18.11
Van-der-waals TM4 T 182 4x38 s17s18 R 282 C.s17s18.11
Hydrophobic TM3 R 167 3x50 s5s6 I 67 N.s5s6.08
Polar ICL2 V 175 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 V 175 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 V 175 34x51 S16 Y 246 C.S16.03
Polar ICL2 R 181 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 181 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 V 175 34x51 S9 C 137 N.S9.01
Hydrophobic TM3 R 167 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 167 3x50 s5s6 V 66 N.s5s6.07
Ionic ICL2 R 181 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 181 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 181 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 181 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 S 263 5x67 s15s16 Y 241 C.s15s16.03