Beta-arrestin-2 - NOP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
NOP 74.8
Beta-arrestin-2 78.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 159 34x54 S8 L 130 N.S8.03
Hydrophobic TM3 R 148 3x50 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 R 148 3x50 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 S 249 - S6 K 78 N.S6.03
Polar ICL2 R 162 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 162 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 V 265 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 265 6x37 s5s6 L 72 N.s5s6.08
Polar ICL2 I 156 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 I 156 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 I 156 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 L 264 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 264 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 L 258 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 258 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 K 254 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 K 254 6x26 S6 R 77 N.S6.02
Polar ICL1 K 81 12x49 s20c Q 407 C.s20c.17
Van-der-waals ICL1 K 81 12x49 s20c Q 407 C.s20c.17
Hydrophobic ICL3 S 249 - s15s16 F 245 C.s15s16.03
Hydrophobic TM6 L 258 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 L 258 6x30 S6 F 76 N.S6.01
Polar TM2 A 85 2x38 s5s6 D 68 N.s5s6.04
Polar TM3 R 148 3x50 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 148 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 86 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 T 86 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 N 87 2x40 s5s6 V 71 N.s5s6.07
Polar TM3 R 148 3x50 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 R 148 3x50 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 I 156 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 I 156 34x51 S15 I 242 C.S15.14
Hydrophobic ICL2 L 159 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 159 34x54 S16 Y 250 C.S16.03
Hydrophobic TM3 I 152 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 P 155 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 155 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 152 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 152 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 H 154 3x56 s15s16 S 246 C.s15s16.04
Polar ICL1 K 81 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 K 81 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 81 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL2 R 162 34x57 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 R 162 34x57 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 V 245 5x68 S6 F 76 N.S6.01
Polar TM6 S 251 6x23 S6 D 79 N.S6.04
Hydrophobic TM6 S 251 6x23 S6 D 79 N.S6.04
Van-der-waals TM6 S 251 6x23 S6 D 79 N.S6.04
Polar ICL2 L 159 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 159 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 159 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 L 242 5x65 S6 F 76 N.S6.01
Polar TM5 R 241 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 241 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 241 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 I 261 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 I 261 6x33 s5s6 G 73 N.s5s6.09
Polar TM6 K 254 6x26 S6 F 76 N.S6.01
Hydrophobic TM6 K 254 6x26 S6 F 76 N.S6.01
Van-der-waals TM6 K 254 6x26 S6 F 76 N.S6.01
Hydrophobic H8 D 323 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 D 323 8x47 s5s6 V 71 N.s5s6.07
Polar TM3 C 153 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 C 153 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 C 153 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 T 84 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 84 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 84 2x37 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 I 261 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 261 6x33 s5s6 L 72 N.s5s6.08
Polar ICL2 P 155 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 155 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 155 34x50 S5 Y 64 N.S5.12
Polar ICL3 S 249 - S6 D 79 N.S6.04
Hydrophobic TM3 A 151 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 151 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 I 156 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 I 156 34x51 S16 A 248 C.S16.01
Hydrophobic TM5 V 245 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 245 5x68 s15s16 F 245 C.s15s16.03
Polar TM6 K 254 6x26 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 K 254 6x26 s5s6 S 75 N.s5s6.11
Polar TM6 N 257 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 N 257 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 N 257 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 R 148 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 148 3x50 s5s6 L 72 N.s5s6.08
Polar ICL3 L 248 - S6 K 78 N.S6.03
Hydrophobic ICL3 L 248 - S6 K 78 N.S6.03
Van-der-waals ICL3 L 248 - S6 K 78 N.S6.03
Hydrophobic TM6 I 261 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 I 261 6x33 s5s6 L 74 N.s5s6.10