ArrestinDb

Beta-arrestin-2 - NOP receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
NOP	74.8
Beta-arrestin-2	78.5

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 20.2

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	ICL2	L	159	34x54	S8	L	130	N.S8.03
Hydrophobic	TM3	R	148	3x50	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL3	S	249	-	S6	K	78	N.S6.03
Hydrophobic	TM6	V	265	6x37	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	I	156	34x51	S16	Y	250	C.S16.03
Hydrophobic	TM6	L	264	6x36	s5s6	L	72	N.s5s6.08
Hydrophobic	TM6	L	258	6x30	s5s6	L	74	N.s5s6.10
Hydrophobic	TM6	K	254	6x26	S6	R	77	N.S6.02
Hydrophobic	ICL3	S	249	-	s15s16	F	245	C.s15s16.03
Hydrophobic	TM6	L	258	6x30	S6	F	76	N.S6.01
Hydrophobic	TM2	T	86	2x39	s5s6	L	72	N.s5s6.08
Hydrophobic	TM2	N	87	2x40	s5s6	V	71	N.s5s6.07
Hydrophobic	TM3	R	148	3x50	s5s6	L	69	N.s5s6.05
Hydrophobic	ICL2	I	156	34x51	S15	I	242	C.S15.14
Hydrophobic	ICL2	L	159	34x54	S16	Y	250	C.S16.03
Hydrophobic	TM3	I	152	3x54	S6	F	76	N.S6.01
Hydrophobic	ICL2	P	155	34x50	s15s16	S	246	C.s15s16.04
Hydrophobic	TM3	I	152	3x54	s5s6	L	74	N.s5s6.10
Hydrophobic	TM3	H	154	3x56	s15s16	S	246	C.s15s16.04
Hydrophobic	ICL1	K	81	12x49	s20c	Y	404	C.s20c.14
Hydrophobic	ICL2	R	162	34x57	s5s6	L	69	N.s5s6.05
Hydrophobic	TM5	V	245	5x68	S6	F	76	N.S6.01
Hydrophobic	TM6	S	251	6x23	S6	D	79	N.S6.04
Hydrophobic	ICL2	L	159	34x54	s5s6	R	66	N.s5s6.02
Hydrophobic	TM5	L	242	5x65	S6	F	76	N.S6.01
Hydrophobic	TM5	R	241	5x64	s15s16	F	245	C.s15s16.03
Hydrophobic	TM6	I	261	6x33	s5s6	G	73	N.s5s6.09
Hydrophobic	TM6	K	254	6x26	S6	F	76	N.S6.01
Hydrophobic	H8	D	323	8x47	s5s6	V	71	N.s5s6.07
Hydrophobic	TM3	C	153	3x55	s15s16	S	246	C.s15s16.04
Hydrophobic	TM2	T	84	2x37	s5s6	D	68	N.s5s6.04
Hydrophobic	TM2	T	84	2x37	s5s6	V	71	N.s5s6.07
Hydrophobic	TM6	I	261	6x33	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	P	155	34x50	S5	Y	64	N.S5.12
Hydrophobic	TM3	A	151	3x53	s5s6	L	69	N.s5s6.05
Hydrophobic	ICL2	I	156	34x51	S16	A	248	C.S16.01
Hydrophobic	TM5	V	245	5x68	s15s16	F	245	C.s15s16.03
Hydrophobic	TM6	N	257	6x29	s5s6	G	73	N.s5s6.09
Hydrophobic	TM3	R	148	3x50	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL3	L	248	-	S6	K	78	N.S6.03
Hydrophobic	TM6	I	261	6x33	s5s6	L	74	N.s5s6.10
Polar	ICL2	R	162	34x57	s5s6	R	66	N.s5s6.02
Polar	ICL2	I	156	34x51	S16	Y	250	C.S16.03
Polar	ICL1	K	81	12x49	s20c	Q	407	C.s20c.17
Polar	TM2	A	85	2x38	s5s6	D	68	N.s5s6.04
Polar	TM3	R	148	3x50	s5s6	D	68	N.s5s6.04
Polar	TM3	R	148	3x50	s5s6	L	69	N.s5s6.05
Polar	ICL1	K	81	12x49	s20c	Y	404	C.s20c.14
Polar	TM6	S	251	6x23	S6	D	79	N.S6.04
Polar	ICL2	L	159	34x54	s5s6	R	66	N.s5s6.02
Polar	TM5	R	241	5x64	s15s16	F	245	C.s15s16.03
Polar	TM6	K	254	6x26	S6	F	76	N.S6.01
Polar	TM3	C	153	3x55	s15s16	S	246	C.s15s16.04
Polar	ICL2	P	155	34x50	S5	Y	64	N.S5.12
Polar	ICL3	S	249	-	S6	D	79	N.S6.04
Polar	TM6	K	254	6x26	s5s6	S	75	N.s5s6.11
Polar	TM6	N	257	6x29	s5s6	G	73	N.s5s6.09
Polar	ICL3	L	248	-	S6	K	78	N.S6.03
Van-der-waals	TM3	R	148	3x50	s5s6	L	74	N.s5s6.10
Van-der-waals	ICL2	R	162	34x57	s5s6	R	66	N.s5s6.02
Van-der-waals	TM6	V	265	6x37	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL2	I	156	34x51	S16	Y	250	C.S16.03
Van-der-waals	TM6	L	264	6x36	s5s6	L	72	N.s5s6.08
Van-der-waals	TM6	L	258	6x30	s5s6	L	74	N.s5s6.10
Van-der-waals	TM6	K	254	6x26	S6	R	77	N.S6.02
Van-der-waals	ICL1	K	81	12x49	s20c	Q	407	C.s20c.17
Van-der-waals	TM6	L	258	6x30	S6	F	76	N.S6.01
Van-der-waals	TM3	R	148	3x50	s5s6	D	68	N.s5s6.04
Van-der-waals	TM2	T	86	2x39	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL2	I	156	34x51	S15	I	242	C.S15.14
Van-der-waals	ICL2	L	159	34x54	S16	Y	250	C.S16.03
Van-der-waals	ICL2	P	155	34x50	s15s16	S	246	C.s15s16.04
Van-der-waals	TM3	I	152	3x54	s5s6	L	74	N.s5s6.10
Van-der-waals	ICL1	K	81	12x49	s20c	Y	404	C.s20c.14
Van-der-waals	ICL2	R	162	34x57	s5s6	L	69	N.s5s6.05
Van-der-waals	TM6	S	251	6x23	S6	D	79	N.S6.04
Van-der-waals	ICL2	L	159	34x54	s5s6	R	66	N.s5s6.02
Van-der-waals	TM5	R	241	5x64	s15s16	F	245	C.s15s16.03
Van-der-waals	TM6	I	261	6x33	s5s6	G	73	N.s5s6.09
Van-der-waals	TM6	K	254	6x26	S6	F	76	N.S6.01
Van-der-waals	H8	D	323	8x47	s5s6	V	71	N.s5s6.07
Van-der-waals	TM3	C	153	3x55	s15s16	S	246	C.s15s16.04
Van-der-waals	TM2	T	84	2x37	s5s6	D	68	N.s5s6.04
Van-der-waals	TM6	I	261	6x33	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL2	P	155	34x50	S5	Y	64	N.S5.12
Van-der-waals	TM3	A	151	3x53	s5s6	L	69	N.s5s6.05
Van-der-waals	ICL2	I	156	34x51	S16	A	248	C.S16.01
Van-der-waals	TM5	V	245	5x68	s15s16	F	245	C.s15s16.03
Van-der-waals	TM6	K	254	6x26	s5s6	S	75	N.s5s6.11
Van-der-waals	TM6	N	257	6x29	s5s6	G	73	N.s5s6.09
Van-der-waals	TM3	R	148	3x50	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL3	L	248	-	S6	K	78	N.S6.03
Van-der-waals	TM6	I	261	6x33	s5s6	L	74	N.s5s6.10

Showing 1 to 93 of 93 entries

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Main reference

Beta-arrestin-2 - NOP receptor complex model Download Full