Beta-arrestin-1 - OPN1SW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OPN1SW 81.0
Beta-arrestin-1 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic H8 K 313 8x56 s20c E 407 C.s20c.17
Polar H8 K 313 8x56 s20c E 407 C.s20c.17
Van-der-waals H8 K 313 8x56 s20c E 407 C.s20c.17
Hydrophobic TM3 I 133 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic C-term T 326 - s20c E 407 C.s20c.17
Hydrophobic TM3 V 132 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 V 132 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 M 251 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 133 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 133 3x54 s5s6 L 71 N.s5s6.08
Polar C-term D 322 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term D 322 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term D 322 - s9s10 K 160 N.s9s10.12
Polar C-term Q 330 - s20c D 408 C.s20c.18
Hydrophobic C-term Q 330 - s20c D 408 C.s20c.18
Van-der-waals C-term Q 330 - s20c D 408 C.s20c.18
Polar C-term E 333 - s20c S 412 C.s20c.22
Hydrophobic TM5 Q 231 5x72 s15s16 L 243 C.s15s16.02
Van-der-waals TM5 Q 231 5x72 s15s16 L 243 C.s15s16.02
Polar C-term E 323 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term E 323 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term E 323 - s9s10 K 160 N.s9s10.12
Hydrophobic TM5 L 224 5x65 s5s6 L 68 N.s5s6.05
Hydrophobic C-term A 319 - s20c E 407 C.s20c.17
Van-der-waals C-term A 319 - s20c E 407 C.s20c.17
Ionic C-term E 323 - S10 R 165 N.S10.03
Polar C-term E 323 - S10 R 165 N.S10.03
Hydrophobic C-term E 323 - S10 R 165 N.S10.03
Van-der-waals C-term E 323 - S10 R 165 N.S10.03
Hydrophobic TM5 V 227 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 L 220 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic C-term Q 330 - s20c A 392 C.s20c.02
Van-der-waals C-term Q 330 - s20c A 392 C.s20c.02
Ionic C-term D 325 - S5 R 62 N.S5.11
Polar C-term D 325 - S5 R 62 N.S5.11
Van-der-waals C-term D 325 - S5 R 62 N.S5.11
Hydrophobic C-term T 332 - S20 D 390 C.S20.05
Hydrophobic TM5 Q 231 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 231 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 T 237 6x26 S6 F 75 N.S6.01
Van-der-waals TM6 T 237 6x26 S6 F 75 N.S6.01
Hydrophobic TM6 E 243 6x32 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 Q 231 5x72 S6 K 77 N.S6.03
Polar TM3 R 129 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 129 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 129 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 A 240 6x29 s5s6 L 73 N.s5s6.10
Polar C-term S 328 - S1 K 11 N.S1.04
Van-der-waals C-term S 328 - S1 K 11 N.S1.04
Polar H8 N 304 8x47 s5s6 V 70 N.s5s6.07
Polar TM6 S 234 6x23 S6 R 76 N.S6.02
Hydrophobic TM5 V 227 5x68 s15s16 F 244 C.s15s16.03
Polar C-term S 329 - s20c D 408 C.s20c.18
Hydrophobic C-term S 329 - s20c D 408 C.s20c.18
Van-der-waals C-term S 329 - s20c D 408 C.s20c.18
Polar C-term Q 330 - s20c R 395 C.s20c.05
Hydrophobic TM2 L 66 2x39 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 L 66 2x39 s5s6 E 66 N.s5s6.03
Ionic ICL1 K 61 12x49 s20c E 405 C.s20c.15
Polar ICL1 K 61 12x49 s20c E 405 C.s20c.15
Hydrophobic ICL1 K 61 12x49 s20c E 405 C.s20c.15
Van-der-waals ICL1 K 61 12x49 s20c E 405 C.s20c.15
Polar C-term E 333 - S20 D 390 C.S20.05
Polar C-term S 329 - s20c E 406 C.s20c.16
Hydrophobic C-term S 329 - s20c E 406 C.s20c.16
Van-der-waals C-term S 329 - s20c E 406 C.s20c.16
Polar TM6 T 236 6x25 S6 R 76 N.S6.02
Hydrophobic TM6 T 236 6x25 S6 R 76 N.S6.02
Van-der-waals TM6 T 236 6x25 S6 R 76 N.S6.02
Polar C-term T 332 - s20c R 393 C.s20c.03
Polar H8 K 305 8x48 s5s6 G 72 N.s5s6.09
Hydrophobic H8 K 305 8x48 s5s6 G 72 N.s5s6.09
Van-der-waals H8 K 305 8x48 s5s6 G 72 N.s5s6.09
Polar TM3 I 133 3x54 s5s6 R 65 N.s5s6.02
Hydrophobic C-term S 328 - s20c D 408 C.s20c.18
Van-der-waals C-term S 328 - s20c D 408 C.s20c.18
Polar ICL2 R 141 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 141 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 141 34x55 s8s9 T 136 N.s8s9.07
Polar C-term Q 330 - S1 K 11 N.S1.04
Hydrophobic C-term Q 330 - S1 K 11 N.S1.04
Van-der-waals C-term Q 330 - S1 K 11 N.S1.04
Hydrophobic ICL1 K 61 12x49 s20c E 404 C.s20c.14
Polar C-term C 327 - s17s18 K 292 C.s17s18.18
Hydrophobic C-term C 327 - s17s18 K 292 C.s17s18.18
Van-der-waals C-term C 327 - s17s18 K 292 C.s17s18.18
Hydrophobic TM2 L 66 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 L 66 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 V 244 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 V 244 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 M 247 6x36 s5s6 L 71 N.s5s6.08
Polar C-term T 332 - s20c A 392 C.s20c.02
Hydrophobic C-term T 332 - s20c A 392 C.s20c.02
Van-der-waals C-term T 332 - s20c A 392 C.s20c.02
Polar C-term T 326 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term T 326 - s9s10 K 160 N.s9s10.12
Hydrophobic TM6 S 234 6x23 S6 K 77 N.S6.03
Ionic ICL2 R 141 34x55 s8s9 D 135 N.s8s9.06
Polar ICL2 R 141 34x55 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 141 34x55 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 141 34x55 s8s9 D 135 N.s8s9.06
Hydrophobic TM3 I 133 3x54 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 I 133 3x54 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 V 244 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 244 6x33 s5s6 L 71 N.s5s6.08
Polar ICL2 R 141 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 141 34x55 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 141 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 F 140 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 F 140 34x54 s8s9 T 136 N.s8s9.07
Polar C-term S 324 - S10 R 165 N.S10.03
Van-der-waals C-term S 324 - S10 R 165 N.S10.03
Hydrophobic TM3 K 135 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 K 135 3x56 s15s16 N 245 C.s15s16.04
Polar C-term S 329 - s20c R 395 C.s20c.05
Hydrophobic C-term S 329 - s20c R 395 C.s20c.05
Van-der-waals C-term S 329 - s20c R 395 C.s20c.05
Polar C-term T 321 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term T 321 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term T 321 - s9s10 K 160 N.s9s10.12