S-arrestin - OPN1SW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OPN1SW 80.5
S-arrestin 77.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 227 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 A 240 6x29 s5s6 L 81 N.s5s6.10
Polar TM5 V 227 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 V 227 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 V 227 5x68 S6 R 85 N.S6.03
Polar TM2 Q 64 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 Q 64 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 Q 64 2x37 s5s6 D 75 N.s5s6.04
Polar H8 N 304 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 304 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 304 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 K 135 3x56 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 K 135 3x56 s15s16 Y 254 C.s15s16.03
Polar TM2 Q 64 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 Q 64 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 Q 64 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic H8 N 304 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 304 8x47 s5s6 V 78 N.s5s6.07
Polar TM5 Q 230 5x71 s17s18 D 321 C.s17s18.37
Van-der-waals TM5 Q 230 5x71 s17s18 D 321 C.s17s18.37
Polar TM5 Q 230 5x71 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 Q 230 5x71 s17s18 T 323 C.s17s18.39
Polar H8 Q 306 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 Q 306 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 Q 306 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic C-term E 323 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term E 323 - s9s10 K 170 N.s9s10.12
Hydrophobic TM5 Q 231 5x72 S6 L 87 N.S6.05
Van-der-waals TM5 Q 231 5x72 S6 L 87 N.S6.05
Hydrophobic TM6 V 244 6x33 s5s6 I 79 N.s5s6.08
Polar TM6 T 236 6x25 S6 D 86 N.S6.04
Hydrophobic TM6 T 236 6x25 S6 D 86 N.S6.04
Van-der-waals TM6 T 236 6x25 S6 D 86 N.S6.04
Ionic ICL2 R 141 34x55 s8s9 D 142 N.s8s9.06
Polar ICL2 R 141 34x55 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 R 141 34x55 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 R 141 34x55 s8s9 D 142 N.s8s9.06
Hydrophobic TM3 I 133 3x54 s5s6 I 79 N.s5s6.08
Polar TM5 Q 231 5x72 S6 D 86 N.S6.04
Hydrophobic TM5 Q 231 5x72 S6 D 86 N.S6.04
Polar ICL3 E 233 - s7s8 Y 129 N.s7s8.05
Ionic H8 K 305 8x48 s5s6 D 77 N.s5s6.06
Polar H8 K 305 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 305 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 305 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 L 220 5x61 s5s6 I 79 N.s5s6.08
Polar H8 Q 306 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 Q 306 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 Q 306 8x49 s5s6 D 77 N.s5s6.06
Polar TM6 T 237 6x26 S6 D 86 N.S6.04
Polar TM5 Q 230 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 Q 230 5x71 S6 R 85 N.S6.03
Polar C-term T 332 - S20 E 381 C.S20.05
Hydrophobic C-term T 332 - S20 E 381 C.S20.05
Van-der-waals C-term T 332 - S20 E 381 C.S20.05
Hydrophobic TM6 M 251 6x40 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 L 224 5x65 s5s6 L 81 N.s5s6.10
Ionic ICL1 K 61 12x49 s5s6 D 75 N.s5s6.04
Polar ICL1 K 61 12x49 s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 K 61 12x49 s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 K 61 12x49 s5s6 D 75 N.s5s6.04
Polar C-term T 326 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term T 326 - s1s2 R 22 N.s1s2.02
Ionic TM3 K 135 3x56 S16 D 257 C.S16.01
Polar TM3 K 135 3x56 S16 D 257 C.S16.01
Hydrophobic TM3 K 135 3x56 S16 D 257 C.S16.01
Van-der-waals TM3 K 135 3x56 S16 D 257 C.S16.01
Polar ICL2 R 141 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 141 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 141 34x55 S16 Y 259 C.S16.03
Polar TM6 S 234 6x23 S6 D 86 N.S6.04
Hydrophobic TM6 S 234 6x23 S6 D 86 N.S6.04
Van-der-waals TM6 S 234 6x23 S6 D 86 N.S6.04
Polar C-term Q 330 - S20 E 381 C.S20.05
Hydrophobic TM6 M 247 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 247 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 R 141 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 141 34x55 s8s9 K 145 N.s8s9.09
Ionic TM6 K 239 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 K 239 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 239 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM2 L 66 2x39 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 L 66 2x39 s5s6 I 76 N.s5s6.05
Hydrophobic TM2 L 70 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 N 139 34x53 S16 D 257 C.S16.01
Van-der-waals ICL2 N 139 34x53 S16 D 257 C.S16.01
Hydrophobic TM3 R 129 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 244 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 244 6x33 s5s6 L 81 N.s5s6.10
Ionic C-term E 323 - s1s2 R 22 N.s1s2.02
Polar C-term E 323 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term E 323 - s1s2 R 22 N.s1s2.02
Polar TM5 Q 231 5x72 S6 R 85 N.S6.03
Hydrophobic TM5 Q 231 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 Q 231 5x72 S6 R 85 N.S6.03
Polar TM3 K 135 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 K 135 3x56 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 K 135 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 R 129 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 129 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 I 133 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 133 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 133 3x54 s15s16 Y 254 C.s15s16.03
Polar ICL2 N 139 34x53 S16 Y 258 C.S16.02
Van-der-waals ICL2 N 139 34x53 S16 Y 258 C.S16.02
Polar TM3 K 135 3x56 S5 Y 71 N.S5.12
Hydrophobic TM3 K 135 3x56 S5 Y 71 N.S5.12
Van-der-waals TM3 K 135 3x56 S5 Y 71 N.S5.12
Hydrophobic TM5 L 224 5x65 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 L 224 5x65 S6 F 83 N.S6.01
Hydrophobic TM3 L 125 3x46 s5s6 V 78 N.s5s6.07
Polar H8 K 305 8x48 s5s6 G 80 N.s5s6.09
Hydrophobic H8 K 305 8x48 s5s6 G 80 N.s5s6.09
Van-der-waals H8 K 305 8x48 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 T 236 6x25 s9s10 E 165 N.s9s10.07