Beta-arrestin-1 -
Rhodopsin complex model
GPCR CLASS (FAMILY)
SPECIES
ARRESTIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
Chain | pLDDT score avg |
---|---|
Rhodopsin | 87.7 |
Beta-arrestin-1 | 79.8 |
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.8
GPCR - Arrestin interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(arrestin residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-Arrestin backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Arrestin,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Arrestin segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | K | 141 | 3x56 | s5s6 | R | 65 | N.s5s6.02 |
Van-der-waals | TM3 | K | 141 | 3x56 | s5s6 | R | 65 | N.s5s6.02 |
Polar | C-term | E | 332 | - | s20c | G | 409 | C.s20c.19 |
Hydrophobic | C-term | E | 332 | - | s20c | G | 409 | C.s20c.19 |
Van-der-waals | C-term | E | 332 | - | s20c | G | 409 | C.s20c.19 |
Hydrophobic | TM5 | Q | 237 | 5x72 | s15s16 | F | 244 | C.s15s16.03 |
Van-der-waals | TM5 | Q | 237 | 5x72 | s15s16 | F | 244 | C.s15s16.03 |
Hydrophobic | C-term | A | 333 | - | s20c | E | 405 | C.s20c.15 |
Ionic | TM3 | K | 141 | 3x56 | s5s6 | D | 67 | N.s5s6.04 |
Hydrophobic | TM6 | V | 250 | 6x33 | s5s6 | L | 68 | N.s5s6.05 |
Ionic | C-term | D | 331 | - | s9s10 | K | 160 | N.s9s10.12 |
Polar | C-term | D | 331 | - | s9s10 | K | 160 | N.s9s10.12 |
Hydrophobic | C-term | D | 331 | - | s9s10 | K | 160 | N.s9s10.12 |
Van-der-waals | C-term | D | 331 | - | s9s10 | K | 160 | N.s9s10.12 |
Hydrophobic | C-term | A | 333 | - | s20c | E | 406 | C.s20c.16 |
Van-der-waals | C-term | A | 333 | - | s20c | E | 406 | C.s20c.16 |
Hydrophobic | ICL2 | N | 145 | 34x53 | s8s9 | T | 136 | N.s8s9.07 |
Hydrophobic | TM3 | V | 139 | 3x54 | s5s6 | D | 67 | N.s5s6.04 |
Van-der-waals | TM3 | V | 139 | 3x54 | s5s6 | D | 67 | N.s5s6.04 |
Polar | ICL2 | R | 147 | 34x55 | s8s9 | G | 132 | N.s8s9.03 |
Van-der-waals | ICL2 | R | 147 | 34x55 | s8s9 | G | 132 | N.s8s9.03 |
Polar | TM6 | T | 242 | 6x25 | S6 | D | 78 | N.S6.04 |
Van-der-waals | TM6 | T | 242 | 6x25 | S6 | D | 78 | N.S6.04 |
Hydrophobic | TM6 | T | 243 | 6x26 | S6 | F | 75 | N.S6.01 |
Van-der-waals | TM6 | T | 243 | 6x26 | S6 | F | 75 | N.S6.01 |
Hydrophobic | TM6 | M | 257 | 6x40 | s5s6 | L | 71 | N.s5s6.08 |
Polar | TM3 | V | 139 | 3x54 | s5s6 | R | 65 | N.s5s6.02 |
Hydrophobic | TM5 | Q | 237 | 5x72 | S6 | K | 77 | N.S6.03 |
Van-der-waals | TM5 | Q | 237 | 5x72 | S6 | K | 77 | N.S6.03 |
Polar | C-term | E | 341 | - | s20c | Q | 414 | C.s20c.24 |
Hydrophobic | C-term | E | 341 | - | s20c | Q | 414 | C.s20c.24 |
Van-der-waals | C-term | E | 341 | - | s20c | Q | 414 | C.s20c.24 |
Polar | ICL2 | R | 147 | 34x55 | s8s9 | D | 135 | N.s8s9.06 |
Hydrophobic | ICL2 | R | 147 | 34x55 | s8s9 | D | 135 | N.s8s9.06 |
Van-der-waals | ICL2 | R | 147 | 34x55 | s8s9 | D | 135 | N.s8s9.06 |
Polar | TM6 | T | 243 | 6x26 | S6 | R | 76 | N.S6.02 |
Ionic | ICL1 | K | 67 | 12x49 | s20c | E | 405 | C.s20c.15 |
Polar | ICL1 | K | 67 | 12x49 | s20c | E | 405 | C.s20c.15 |
Hydrophobic | ICL1 | K | 67 | 12x49 | s20c | E | 405 | C.s20c.15 |
Van-der-waals | ICL1 | K | 67 | 12x49 | s20c | E | 405 | C.s20c.15 |
Polar | TM3 | R | 135 | 3x50 | s5s6 | V | 70 | N.s5s6.07 |
Hydrophobic | TM3 | R | 135 | 3x50 | s5s6 | V | 70 | N.s5s6.07 |
Van-der-waals | TM3 | R | 135 | 3x50 | s5s6 | V | 70 | N.s5s6.07 |
Polar | ICL2 | R | 147 | 34x55 | s8s9 | P | 133 | N.s8s9.04 |
Van-der-waals | ICL2 | R | 147 | 34x55 | s8s9 | P | 133 | N.s8s9.04 |
Hydrophobic | TM3 | V | 138 | 3x53 | s5s6 | D | 67 | N.s5s6.04 |
Van-der-waals | TM3 | V | 138 | 3x53 | s5s6 | D | 67 | N.s5s6.04 |
Hydrophobic | TM6 | E | 249 | 6x32 | s5s6 | L | 73 | N.s5s6.10 |
Van-der-waals | TM6 | E | 249 | 6x32 | s5s6 | L | 73 | N.s5s6.10 |
Hydrophobic | TM6 | V | 250 | 6x33 | s5s6 | L | 71 | N.s5s6.08 |
Polar | H8 | Q | 312 | 8x49 | s5s6 | D | 69 | N.s5s6.06 |
Hydrophobic | H8 | Q | 312 | 8x49 | s5s6 | D | 69 | N.s5s6.06 |
Van-der-waals | H8 | Q | 312 | 8x49 | s5s6 | D | 69 | N.s5s6.06 |
Hydrophobic | C-term | D | 331 | - | s20c | E | 407 | C.s20c.17 |
Van-der-waals | C-term | D | 331 | - | s20c | E | 407 | C.s20c.17 |
Polar | ICL2 | R | 147 | 34x55 | s8s9 | G | 137 | N.s8s9.08 |
Hydrophobic | H8 | N | 310 | 8x47 | s5s6 | G | 72 | N.s5s6.09 |
Hydrophobic | ICL2 | R | 147 | 34x55 | s8s9 | T | 136 | N.s8s9.07 |
Van-der-waals | ICL2 | R | 147 | 34x55 | s8s9 | T | 136 | N.s8s9.07 |
Hydrophobic | TM5 | V | 230 | 5x65 | s5s6 | L | 68 | N.s5s6.05 |
Polar | ICL2 | R | 147 | 34x55 | s8s9 | E | 134 | N.s8s9.05 |
Hydrophobic | ICL2 | R | 147 | 34x55 | s8s9 | E | 134 | N.s8s9.05 |
Van-der-waals | ICL2 | R | 147 | 34x55 | s8s9 | E | 134 | N.s8s9.05 |
Hydrophobic | TM2 | L | 72 | 2x39 | s5s6 | E | 66 | N.s5s6.03 |
Van-der-waals | TM2 | L | 72 | 2x39 | s5s6 | E | 66 | N.s5s6.03 |
Hydrophobic | TM6 | T | 242 | 6x25 | S6 | R | 76 | N.S6.02 |
Van-der-waals | TM6 | T | 242 | 6x25 | S6 | R | 76 | N.S6.02 |
Hydrophobic | C-term | E | 332 | - | s20c | E | 407 | C.s20c.17 |
Van-der-waals | C-term | E | 332 | - | s20c | E | 407 | C.s20c.17 |
Hydrophobic | C-term | A | 333 | - | s20c | E | 407 | C.s20c.17 |
Van-der-waals | C-term | A | 333 | - | s20c | E | 407 | C.s20c.17 |
Hydrophobic | TM5 | A | 233 | 5x68 | s15s16 | F | 244 | C.s15s16.03 |
Hydrophobic | C-term | T | 336 | - | s20c | G | 411 | C.s20c.21 |
Van-der-waals | C-term | T | 336 | - | s20c | G | 411 | C.s20c.21 |
Hydrophobic | ICL3 | S | 240 | - | S6 | K | 77 | N.S6.03 |
Hydrophobic | TM6 | V | 250 | 6x33 | s5s6 | L | 73 | N.s5s6.10 |
Van-der-waals | TM6 | V | 250 | 6x33 | s5s6 | L | 73 | N.s5s6.10 |
Hydrophobic | TM2 | L | 72 | 2x39 | s5s6 | V | 70 | N.s5s6.07 |
Van-der-waals | TM2 | L | 72 | 2x39 | s5s6 | V | 70 | N.s5s6.07 |
Hydrophobic | TM5 | Q | 237 | 5x72 | s15s16 | L | 243 | C.s15s16.02 |
Van-der-waals | TM5 | Q | 237 | 5x72 | s15s16 | L | 243 | C.s15s16.02 |
Hydrophobic | C-term | E | 332 | - | s1s2 | P | 14 | N.s1s2.02 |
Van-der-waals | C-term | E | 332 | - | s1s2 | P | 14 | N.s1s2.02 |
Hydrophobic | C-term | E | 332 | - | s9s10 | K | 160 | N.s9s10.12 |
Van-der-waals | C-term | E | 332 | - | s9s10 | K | 160 | N.s9s10.12 |
Polar | TM3 | K | 141 | 3x56 | s15s16 | N | 245 | C.s15s16.04 |
Hydrophobic | TM3 | K | 141 | 3x56 | s15s16 | N | 245 | C.s15s16.04 |
Van-der-waals | TM3 | K | 141 | 3x56 | s15s16 | N | 245 | C.s15s16.04 |
Hydrophobic | C-term | T | 336 | - | s20c | T | 410 | C.s20c.20 |
Hydrophobic | TM3 | V | 138 | 3x53 | s5s6 | E | 66 | N.s5s6.03 |
Polar | ICL3 | S | 240 | - | S6 | R | 76 | N.S6.02 |
Hydrophobic | TM3 | R | 135 | 3x50 | s5s6 | L | 71 | N.s5s6.08 |
Van-der-waals | TM3 | R | 135 | 3x50 | s5s6 | L | 71 | N.s5s6.08 |
Hydrophobic | ICL2 | F | 146 | 34x54 | s8s9 | T | 136 | N.s8s9.07 |
Polar | C-term | D | 330 | - | s9s10 | K | 160 | N.s9s10.12 |
Hydrophobic | C-term | D | 330 | - | s9s10 | K | 160 | N.s9s10.12 |
Van-der-waals | C-term | D | 330 | - | s9s10 | K | 160 | N.s9s10.12 |
Ionic | ICL3 | E | 239 | - | S6 | K | 77 | N.S6.03 |
Polar | ICL3 | E | 239 | - | S6 | K | 77 | N.S6.03 |
Hydrophobic | ICL3 | E | 239 | - | S6 | K | 77 | N.S6.03 |
Van-der-waals | ICL3 | E | 239 | - | S6 | K | 77 | N.S6.03 |
Ionic | ICL2 | R | 147 | 34x55 | s5s6 | E | 66 | N.s5s6.03 |
Hydrophobic | TM5 | L | 226 | 5x61 | s5s6 | L | 71 | N.s5s6.08 |