ArrestinDb

S-arrestin - Rhodopsin complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
Rhodopsin	85.5
S-arrestin	80.2

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.7

iPTM Score: 0.5

PAE mean: 19.1

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	TM2	T	70	2x37	s5s6	E	74	N.s5s6.03
Hydrophobic	ICL2	R	147	34x55	s8s9	D	142	N.s8s9.06
Hydrophobic	ICL3	S	240	-	S6	D	86	N.S6.04
Hydrophobic	C-term	V	345	-	S20	F	379	C.S20.03
Hydrophobic	C-term	E	341	-	S20	E	381	C.S20.05
Hydrophobic	C-term	E	332	-	s9s10	K	170	N.s9s10.12
Hydrophobic	TM3	L	131	3x46	s5s6	V	78	N.s5s6.07
Hydrophobic	C-term	V	345	-	H1	K	114	N.H1.09
Hydrophobic	TM3	V	139	3x54	s5s6	I	76	N.s5s6.05
Hydrophobic	TM3	K	141	3x56	s15s16	Y	254	C.s15s16.03
Hydrophobic	TM3	V	139	3x54	S6	F	83	N.S6.01
Hydrophobic	TM5	A	233	5x68	s15s16	Y	254	C.s15s16.03
Hydrophobic	TM6	E	249	6x32	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL2	R	147	34x55	s8s9	K	145	N.s8s9.09
Hydrophobic	TM6	A	246	6x29	s5s6	L	81	N.s5s6.10
Hydrophobic	TM6	T	242	6x25	S6	D	86	N.S6.04
Hydrophobic	TM5	L	226	5x61	s5s6	I	79	N.s5s6.08
Hydrophobic	TM3	V	138	3x53	s5s6	D	75	N.s5s6.04
Hydrophobic	C-term	T	340	-	S20	E	381	C.S20.05
Hydrophobic	TM3	V	138	3x53	s5s6	V	78	N.s5s6.07
Hydrophobic	C-term	T	342	-	S20	E	380	C.S20.04
Hydrophobic	TM6	M	253	6x36	s5s6	I	79	N.s5s6.08
Hydrophobic	C-term	K	339	-	S20	E	381	C.S20.05
Hydrophobic	C-term	P	347	-	s19s20	N	376	C.s19s20.51
Hydrophobic	TM2	L	72	2x39	s5s6	E	74	N.s5s6.03
Hydrophobic	TM3	R	135	3x50	s5s6	V	78	N.s5s6.07
Hydrophobic	TM5	Q	237	5x72	S6	R	85	N.S6.03
Hydrophobic	TM2	L	72	2x39	s5s6	D	75	N.s5s6.04
Hydrophobic	TM3	K	141	3x56	s5s6	Q	73	N.s5s6.02
Hydrophobic	TM6	V	250	6x33	s5s6	L	81	N.s5s6.10
Hydrophobic	TM2	L	72	2x39	s5s6	V	78	N.s5s6.07
Hydrophobic	TM5	V	230	5x65	S6	F	83	N.S6.01
Hydrophobic	TM6	V	250	6x33	s5s6	I	79	N.s5s6.08
Hydrophobic	TM3	K	141	3x56	s15s16	S	255	C.s15s16.04
Hydrophobic	ICL2	N	145	34x53	S16	D	257	C.S16.01
Hydrophobic	TM3	K	141	3x56	S5	Y	71	N.S5.12
Hydrophobic	TM3	R	135	3x50	s5s6	I	79	N.s5s6.08
Ionic	ICL2	R	147	34x55	s8s9	D	142	N.s8s9.06
Ionic	C-term	E	332	-	s9s10	K	170	N.s9s10.12
Ionic	TM6	K	245	6x28	s9s10	D	166	N.s9s10.08
Ionic	C-term	E	332	-	S10	R	175	N.S10.03
Ionic	C-term	D	330	-	s9s10	K	170	N.s9s10.12
Ionic	TM3	K	141	3x56	S16	D	257	C.S16.01
Polar	ICL2	R	147	34x55	s8s9	D	142	N.s8s9.06
Polar	ICL3	S	240	-	S6	D	86	N.S6.04
Polar	C-term	S	343	-	S1	K	18	N.S1.03
Polar	C-term	E	332	-	s9s10	K	170	N.s9s10.12
Polar	TM3	K	141	3x56	s15s16	Y	254	C.s15s16.03
Polar	ICL2	N	145	34x53	S16	Y	258	C.S16.02
Polar	TM6	K	245	6x28	s9s10	D	166	N.s9s10.08
Polar	H8	N	310	8x47	s5s6	D	77	N.s5s6.06
Polar	C-term	E	332	-	S10	R	175	N.S10.03
Polar	C-term	S	338	-	S20	E	381	C.S20.05
Polar	C-term	D	330	-	s9s10	K	170	N.s9s10.12
Polar	TM5	Q	237	5x72	s15s16	Y	254	C.s15s16.03
Polar	TM6	T	242	6x25	S6	D	86	N.S6.04
Polar	TM6	T	243	6x26	S6	R	84	N.S6.02
Polar	C-term	T	336	-	s1s2	R	22	N.s1s2.02
Polar	TM3	R	135	3x50	s5s6	V	78	N.s5s6.07
Polar	TM5	Q	237	5x72	S6	R	85	N.S6.03
Polar	H8	Q	312	8x49	s5s6	D	77	N.s5s6.06
Polar	H8	N	310	8x47	s5s6	V	78	N.s5s6.07
Polar	TM5	Q	236	5x71	S6	R	85	N.S6.03
Polar	TM6	T	242	6x25	S6	R	84	N.S6.02
Polar	TM3	K	141	3x56	s15s16	S	255	C.s15s16.04
Polar	ICL2	N	145	34x53	S16	D	257	C.S16.01
Polar	TM3	K	141	3x56	S5	Y	71	N.S5.12
Van-der-waals	TM2	T	70	2x37	s5s6	E	74	N.s5s6.03
Van-der-waals	ICL2	R	147	34x55	s8s9	D	142	N.s8s9.06
Van-der-waals	C-term	S	343	-	S1	K	18	N.S1.03
Van-der-waals	C-term	V	345	-	S20	F	379	C.S20.03
Van-der-waals	C-term	E	332	-	s9s10	K	170	N.s9s10.12
Van-der-waals	TM3	V	139	3x54	s5s6	I	76	N.s5s6.05
Van-der-waals	TM3	K	141	3x56	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	N	145	34x53	S16	Y	258	C.S16.02
Van-der-waals	TM6	K	245	6x28	s9s10	D	166	N.s9s10.08
Van-der-waals	C-term	E	332	-	S10	R	175	N.S10.03
Van-der-waals	C-term	S	338	-	S20	E	381	C.S20.05
Van-der-waals	C-term	D	330	-	s9s10	K	170	N.s9s10.12
Van-der-waals	ICL2	R	147	34x55	s8s9	K	145	N.s8s9.09
Van-der-waals	TM6	T	242	6x25	S6	D	86	N.S6.04
Van-der-waals	TM3	V	138	3x53	s5s6	D	75	N.s5s6.04
Van-der-waals	C-term	T	340	-	S20	E	381	C.S20.05
Van-der-waals	TM6	M	253	6x36	s5s6	I	79	N.s5s6.08
Van-der-waals	TM2	L	72	2x39	s5s6	E	74	N.s5s6.03
Van-der-waals	TM3	R	135	3x50	s5s6	V	78	N.s5s6.07
Van-der-waals	TM5	Q	237	5x72	S6	R	85	N.S6.03
Van-der-waals	TM2	L	72	2x39	s5s6	D	75	N.s5s6.04
Van-der-waals	TM6	V	250	6x33	s5s6	L	81	N.s5s6.10
Van-der-waals	TM2	L	72	2x39	s5s6	V	78	N.s5s6.07
Van-der-waals	TM5	Q	236	5x71	S6	R	85	N.S6.03
Van-der-waals	TM3	K	141	3x56	s15s16	S	255	C.s15s16.04
Van-der-waals	ICL2	N	145	34x53	S16	D	257	C.S16.01
Van-der-waals	TM3	K	141	3x56	S5	Y	71	N.S5.12

Showing 1 to 94 of 94 entries

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S-arrestin - Rhodopsin complex model Download Full