S-arrestin - Rhodopsin complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
Rhodopsin 85.5
S-arrestin 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 19.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 70 2x37 s5s6 E 74 N.s5s6.03
Van-der-waals TM2 T 70 2x37 s5s6 E 74 N.s5s6.03
Ionic ICL2 R 147 34x55 s8s9 D 142 N.s8s9.06
Polar ICL2 R 147 34x55 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 R 147 34x55 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 R 147 34x55 s8s9 D 142 N.s8s9.06
Polar ICL3 S 240 - S6 D 86 N.S6.04
Hydrophobic ICL3 S 240 - S6 D 86 N.S6.04
Polar C-term S 343 - S1 K 18 N.S1.03
Van-der-waals C-term S 343 - S1 K 18 N.S1.03
Hydrophobic C-term V 345 - S20 F 379 C.S20.03
Van-der-waals C-term V 345 - S20 F 379 C.S20.03
Hydrophobic C-term E 341 - S20 E 381 C.S20.05
Ionic C-term E 332 - s9s10 K 170 N.s9s10.12
Polar C-term E 332 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term E 332 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term E 332 - s9s10 K 170 N.s9s10.12
Hydrophobic TM3 L 131 3x46 s5s6 V 78 N.s5s6.07
Hydrophobic C-term V 345 - H1 K 114 N.H1.09
Hydrophobic TM3 V 139 3x54 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 V 139 3x54 s5s6 I 76 N.s5s6.05
Polar TM3 K 141 3x56 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 K 141 3x56 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 K 141 3x56 s15s16 Y 254 C.s15s16.03
Polar ICL2 N 145 34x53 S16 Y 258 C.S16.02
Van-der-waals ICL2 N 145 34x53 S16 Y 258 C.S16.02
Ionic TM6 K 245 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 K 245 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 245 6x28 s9s10 D 166 N.s9s10.08
Polar H8 N 310 8x47 s5s6 D 77 N.s5s6.06
Ionic C-term E 332 - S10 R 175 N.S10.03
Polar C-term E 332 - S10 R 175 N.S10.03
Van-der-waals C-term E 332 - S10 R 175 N.S10.03
Polar C-term S 338 - S20 E 381 C.S20.05
Van-der-waals C-term S 338 - S20 E 381 C.S20.05
Hydrophobic TM3 V 139 3x54 S6 F 83 N.S6.01
Hydrophobic TM5 A 233 5x68 s15s16 Y 254 C.s15s16.03
Ionic C-term D 330 - s9s10 K 170 N.s9s10.12
Polar C-term D 330 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term D 330 - s9s10 K 170 N.s9s10.12
Hydrophobic TM6 E 249 6x32 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 R 147 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 147 34x55 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 A 246 6x29 s5s6 L 81 N.s5s6.10
Polar TM5 Q 237 5x72 s15s16 Y 254 C.s15s16.03
Polar TM6 T 242 6x25 S6 D 86 N.S6.04
Hydrophobic TM6 T 242 6x25 S6 D 86 N.S6.04
Van-der-waals TM6 T 242 6x25 S6 D 86 N.S6.04
Ionic TM3 K 141 3x56 S16 D 257 C.S16.01
Hydrophobic TM5 L 226 5x61 s5s6 I 79 N.s5s6.08
Polar TM6 T 243 6x26 S6 R 84 N.S6.02
Hydrophobic TM3 V 138 3x53 s5s6 D 75 N.s5s6.04
Van-der-waals TM3 V 138 3x53 s5s6 D 75 N.s5s6.04
Hydrophobic C-term T 340 - S20 E 381 C.S20.05
Van-der-waals C-term T 340 - S20 E 381 C.S20.05
Hydrophobic TM3 V 138 3x53 s5s6 V 78 N.s5s6.07
Hydrophobic C-term T 342 - S20 E 380 C.S20.04
Hydrophobic TM6 M 253 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 253 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic C-term K 339 - S20 E 381 C.S20.05
Hydrophobic C-term P 347 - s19s20 N 376 C.s19s20.51
Polar C-term T 336 - s1s2 R 22 N.s1s2.02
Hydrophobic TM2 L 72 2x39 s5s6 E 74 N.s5s6.03
Van-der-waals TM2 L 72 2x39 s5s6 E 74 N.s5s6.03
Polar TM3 R 135 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 135 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 135 3x50 s5s6 V 78 N.s5s6.07
Polar TM5 Q 237 5x72 S6 R 85 N.S6.03
Hydrophobic TM5 Q 237 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 Q 237 5x72 S6 R 85 N.S6.03
Hydrophobic TM2 L 72 2x39 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 L 72 2x39 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 K 141 3x56 s5s6 Q 73 N.s5s6.02
Polar H8 Q 312 8x49 s5s6 D 77 N.s5s6.06
Polar H8 N 310 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 V 250 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 250 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 L 72 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 L 72 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 V 230 5x65 S6 F 83 N.S6.01
Polar TM5 Q 236 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 Q 236 5x71 S6 R 85 N.S6.03
Polar TM6 T 242 6x25 S6 R 84 N.S6.02
Hydrophobic TM6 V 250 6x33 s5s6 I 79 N.s5s6.08
Polar TM3 K 141 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 K 141 3x56 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 K 141 3x56 s15s16 S 255 C.s15s16.04
Polar ICL2 N 145 34x53 S16 D 257 C.S16.01
Hydrophobic ICL2 N 145 34x53 S16 D 257 C.S16.01
Van-der-waals ICL2 N 145 34x53 S16 D 257 C.S16.01
Polar TM3 K 141 3x56 S5 Y 71 N.S5.12
Hydrophobic TM3 K 141 3x56 S5 Y 71 N.S5.12
Van-der-waals TM3 K 141 3x56 S5 Y 71 N.S5.12
Hydrophobic TM3 R 135 3x50 s5s6 I 79 N.s5s6.08