S-arrestin - OPN1MW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OPN1MW 74.5
S-arrestin 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 K 157 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 K 157 3x56 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 K 157 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 R 163 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 163 34x55 s8s9 K 145 N.s8s9.09
Hydrophobic TM2 L 92 2x43 s5s6 V 78 N.s5s6.07
Ionic C-term E 346 - s1s2 R 22 N.s1s2.02
Polar C-term E 346 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term E 346 - s1s2 R 22 N.s1s2.02
Hydrophobic TM2 L 88 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 V 154 3x53 s5s6 I 76 N.s5s6.05
Polar TM6 S 258 6x25 S6 R 84 N.S6.02
Van-der-waals TM6 S 258 6x25 S6 R 84 N.S6.02
Hydrophobic TM3 K 157 3x56 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 K 157 3x56 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 T 259 6x26 S6 R 85 N.S6.03
Van-der-waals TM6 T 259 6x26 S6 R 85 N.S6.03
Ionic TM3 K 157 3x56 S16 D 257 C.S16.01
Polar TM3 K 157 3x56 S16 D 257 C.S16.01
Hydrophobic TM3 K 157 3x56 S16 D 257 C.S16.01
Van-der-waals TM3 K 157 3x56 S16 D 257 C.S16.01
Polar ICL2 R 163 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 163 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 163 34x55 S16 Y 259 C.S16.03
Hydrophobic TM6 M 273 6x40 s5s6 I 79 N.s5s6.08
Polar H8 Q 328 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 Q 328 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 Q 328 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 R 151 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 151 3x50 s5s6 I 79 N.s5s6.08
Ionic C-term D 342 - s9s10 K 170 N.s9s10.12
Polar C-term D 342 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term D 342 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term D 342 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term S 348 - s17s18 K 304 C.s17s18.20
Van-der-waals C-term S 348 - s17s18 K 304 C.s17s18.20
Polar TM2 H 86 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 H 86 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 H 86 2x37 s5s6 Q 73 N.s5s6.02
Polar ICL2 N 161 34x53 S16 D 257 C.S16.01
Hydrophobic ICL2 N 161 34x53 S16 D 257 C.S16.01
Van-der-waals ICL2 N 161 34x53 S16 D 257 C.S16.01
Polar TM6 S 256 6x23 S6 D 86 N.S6.04
Hydrophobic TM6 S 256 6x23 S6 D 86 N.S6.04
Van-der-waals TM6 S 256 6x23 S6 D 86 N.S6.04
Polar C-term S 356 - S1 K 18 N.S1.03
Van-der-waals C-term S 356 - S1 K 18 N.S1.03
Polar TM6 S 258 6x25 S6 D 86 N.S6.04
Hydrophobic TM6 S 258 6x25 S6 D 86 N.S6.04
Van-der-waals TM6 S 258 6x25 S6 D 86 N.S6.04
Hydrophobic TM3 V 155 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 155 3x54 S6 F 83 N.S6.01
Hydrophobic TM5 V 249 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 V 155 3x54 s15s16 Y 254 C.s15s16.03
Hydrophobic C-term L 347 - S5 R 70 N.S5.11
Van-der-waals C-term L 347 - S5 R 70 N.S5.11
Polar ICL2 N 161 34x53 S16 Y 258 C.S16.02
Van-der-waals ICL2 N 161 34x53 S16 Y 258 C.S16.02
Polar TM3 K 157 3x56 S5 Y 71 N.S5.12
Hydrophobic TM3 K 157 3x56 S5 Y 71 N.S5.12
Van-der-waals TM3 K 157 3x56 S5 Y 71 N.S5.12
Ionic TM6 K 261 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 K 261 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 K 261 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 261 6x28 s9s10 D 166 N.s9s10.08
Polar C-term S 345 - s5s6 E 74 N.s5s6.03
Hydrophobic C-term S 345 - s5s6 E 74 N.s5s6.03
Van-der-waals C-term S 345 - s5s6 E 74 N.s5s6.03
Polar ICL3 E 255 - s7s8 Y 129 N.s7s8.05
Hydrophobic TM6 M 269 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 269 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic C-term L 347 - S10 L 177 N.S10.05
Van-der-waals C-term L 347 - S10 L 177 N.S10.05
Polar C-term S 351 - S20 E 381 C.S20.05
Van-der-waals C-term S 351 - S20 E 381 C.S20.05
Hydrophobic TM2 N 89 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 89 2x40 s5s6 V 78 N.s5s6.07
Ionic ICL2 R 163 34x55 s8s9 D 142 N.s8s9.06
Polar ICL2 R 163 34x55 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 R 163 34x55 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 R 163 34x55 s8s9 D 142 N.s8s9.06
Polar C-term E 354 - S20 E 381 C.S20.05
Hydrophobic C-term E 354 - S20 E 381 C.S20.05
Van-der-waals C-term E 354 - S20 E 381 C.S20.05
Hydrophobic C-term K 352 - S20 E 381 C.S20.05
Van-der-waals C-term K 352 - S20 E 381 C.S20.05
Ionic C-term D 342 - s1s2 R 22 N.s1s2.02
Polar TM5 V 249 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 V 249 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 V 249 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 Q 253 5x72 S6 L 87 N.S6.05
Van-der-waals TM5 Q 253 5x72 S6 L 87 N.S6.05
Polar TM3 R 151 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 151 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 151 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic H8 N 326 8x47 s5s6 G 80 N.s5s6.09
Hydrophobic H8 N 326 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 326 8x47 s5s6 V 78 N.s5s6.07
Polar TM5 Q 253 5x72 S6 R 85 N.S6.03
Hydrophobic TM5 Q 253 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 Q 253 5x72 S6 R 85 N.S6.03
Hydrophobic TM6 V 266 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 266 6x33 s5s6 L 81 N.s5s6.10
Polar H8 R 327 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 R 327 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 327 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals ICL2 G 160 34x52 S16 D 257 C.S16.01
Van-der-waals TM3 R 151 3x50 s5s6 I 76 N.s5s6.05
Hydrophobic H8 N 326 8x47 s5s6 I 79 N.s5s6.08
Hydrophobic C-term S 351 - s20c A 383 C.s20c.02
Polar H8 Q 328 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 Q 328 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 Q 328 8x49 s5s6 D 77 N.s5s6.06
Polar C-term T 353 - S20 E 381 C.S20.05
Hydrophobic C-term T 353 - S20 E 381 C.S20.05
Van-der-waals C-term T 353 - S20 E 381 C.S20.05
Polar H8 N 326 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 326 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 326 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 R 327 8x48 s5s6 G 80 N.s5s6.09
Van-der-waals H8 R 327 8x48 s5s6 G 80 N.s5s6.09
Polar TM6 T 259 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 E 265 6x32 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 I 246 5x65 S6 F 83 N.S6.01