Beta-arrestin-2 - OPN1LW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OPN1LW 75.4
Beta-arrestin-2 79.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 246 5x65 s5s6 L 72 N.s5s6.08
Polar TM6 S 256 6x23 S6 R 77 N.S6.02
Polar TM3 V 154 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 V 266 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 266 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 Q 253 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 253 5x72 s15s16 F 245 C.s15s16.03
Polar C-term S 349 - s20c D 405 C.s20c.15
Hydrophobic C-term S 349 - s20c D 405 C.s20c.15
Van-der-waals C-term S 349 - s20c D 405 C.s20c.15
Polar ICL2 R 163 34x55 s8s9 P 134 N.s8s9.04
Polar C-term S 351 - s17s18 E 284 C.s17s18.09
Van-der-waals C-term S 351 - s17s18 E 284 C.s17s18.09
Polar C-term S 348 - s20c D 405 C.s20c.15
Hydrophobic C-term S 348 - s20c D 405 C.s20c.15
Van-der-waals C-term S 348 - s20c D 405 C.s20c.15
Polar C-term S 345 - s20c Q 407 C.s20c.17
Hydrophobic C-term S 345 - s20c Q 407 C.s20c.17
Van-der-waals C-term S 345 - s20c Q 407 C.s20c.17
Polar TM6 S 258 6x25 S6 R 77 N.S6.02
Hydrophobic TM6 S 258 6x25 S6 R 77 N.S6.02
Van-der-waals TM6 S 258 6x25 S6 R 77 N.S6.02
Hydrophobic TM3 V 154 3x53 s5s6 E 67 N.s5s6.03
Polar C-term E 346 - s20c L 408 C.s20c.18
Hydrophobic C-term E 346 - s20c L 408 C.s20c.18
Van-der-waals C-term E 346 - s20c L 408 C.s20c.18
Ionic TM2 H 86 2x37 s5s6 E 67 N.s5s6.03
Polar TM2 H 86 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 H 86 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 H 86 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic C-term L 347 - s17s18 K 295 C.s17s18.20
Van-der-waals C-term L 347 - s17s18 K 295 C.s17s18.20
Ionic C-term E 346 - s9s10 K 161 N.s9s10.12
Polar C-term E 346 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term E 346 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term E 346 - s9s10 K 161 N.s9s10.12
Polar H8 N 326 8x47 s5s6 V 71 N.s5s6.07
Polar C-term S 349 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term S 349 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term S 349 - s17s18 R 286 C.s17s18.11
Polar C-term K 352 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term K 352 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term K 352 - s17s18 R 286 C.s17s18.11
Polar C-term S 348 - s20c Q 407 C.s20c.17
Hydrophobic C-term S 348 - s20c Q 407 C.s20c.17
Van-der-waals C-term S 348 - s20c Q 407 C.s20c.17
Polar TM3 R 151 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 151 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 151 3x50 s5s6 V 71 N.s5s6.07
Polar C-term S 351 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term S 351 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term S 351 - s17s18 R 286 C.s17s18.11
Polar C-term L 347 - s20c L 408 C.s20c.18
Hydrophobic C-term L 347 - s20c L 408 C.s20c.18
Van-der-waals C-term L 347 - s20c L 408 C.s20c.18
Polar C-term E 354 - s8s9 D 136 N.s8s9.06
Van-der-waals C-term E 354 - s8s9 D 136 N.s8s9.06
Hydrophobic C-term L 347 - s20c D 405 C.s20c.15
Van-der-waals C-term L 347 - s20c D 405 C.s20c.15
Hydrophobic TM6 M 269 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 269 6x36 s5s6 L 72 N.s5s6.08
Polar ICL2 R 163 34x55 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 R 163 34x55 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 163 34x55 s8s9 D 136 N.s8s9.06
Polar C-term S 351 - s8s9 G 133 N.s8s9.03
Hydrophobic C-term S 351 - s8s9 G 133 N.s8s9.03
Van-der-waals C-term S 351 - s8s9 G 133 N.s8s9.03
Hydrophobic TM3 V 155 3x54 s5s6 L 69 N.s5s6.05
Polar C-term V 355 - s8s9 E 135 N.s8s9.05
Polar C-term T 353 - s8s9 D 136 N.s8s9.06
Hydrophobic C-term T 353 - s8s9 D 136 N.s8s9.06
Van-der-waals C-term T 353 - s8s9 D 136 N.s8s9.06
Polar C-term T 353 - s17s18 G 287 C.s17s18.12
Hydrophobic C-term T 353 - s17s18 G 287 C.s17s18.12
Van-der-waals C-term T 353 - s17s18 G 287 C.s17s18.12
Van-der-waals C-term S 351 - s8s9 P 132 N.s8s9.02
Hydrophobic C-term L 347 - s17s18 K 293 C.s17s18.18
Van-der-waals C-term L 347 - s17s18 K 293 C.s17s18.18
Hydrophobic TM6 A 262 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 262 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic C-term L 347 - s20c Q 407 C.s20c.17
Van-der-waals C-term L 347 - s20c Q 407 C.s20c.17
Polar C-term E 346 - s20c Q 407 C.s20c.17
Hydrophobic C-term E 346 - s20c Q 407 C.s20c.17
Van-der-waals C-term E 346 - s20c Q 407 C.s20c.17
Hydrophobic C-term T 353 - S16 C 252 C.S16.05
Hydrophobic TM3 V 155 3x54 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 V 155 3x54 s5s6 D 68 N.s5s6.04
Polar TM3 K 157 3x56 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 K 157 3x56 s15s16 S 246 C.s15s16.04
Polar C-term S 351 - s8s9 P 134 N.s8s9.04
Hydrophobic C-term S 351 - s8s9 P 134 N.s8s9.04
Van-der-waals C-term S 351 - s8s9 P 134 N.s8s9.04
Polar ICL2 R 163 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 R 163 34x55 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 163 34x55 s8s9 T 137 N.s8s9.07
Polar C-term S 349 - s20c Y 404 C.s20c.14
Hydrophobic C-term S 349 - s20c Y 404 C.s20c.14
Van-der-waals C-term S 349 - s20c Y 404 C.s20c.14
Hydrophobic TM2 L 88 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 L 88 2x39 s5s6 V 71 N.s5s6.07
Polar ICL2 N 161 34x53 s8s9 T 137 N.s8s9.07
Polar C-term L 347 - s20c D 406 C.s20c.16
Hydrophobic C-term L 347 - s20c D 406 C.s20c.16
Van-der-waals C-term L 347 - s20c D 406 C.s20c.16
Hydrophobic C-term K 352 - s8s9 P 134 N.s8s9.04
Van-der-waals C-term K 352 - s8s9 P 134 N.s8s9.04
Hydrophobic TM3 K 157 3x56 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 K 157 3x56 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 R 151 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 E 265 6x32 s5s6 L 74 N.s5s6.10
Hydrophobic C-term A 350 - s8s9 P 134 N.s8s9.04
Van-der-waals C-term A 350 - s8s9 P 134 N.s8s9.04
Polar C-term S 348 - s20c L 408 C.s20c.18
Hydrophobic C-term S 348 - s20c L 408 C.s20c.18
Van-der-waals C-term S 348 - s20c L 408 C.s20c.18
Polar C-term V 355 - s8s9 D 136 N.s8s9.06
Hydrophobic C-term V 355 - s8s9 D 136 N.s8s9.06
Van-der-waals C-term V 355 - s8s9 D 136 N.s8s9.06
Ionic C-term K 352 - s8s9 E 135 N.s8s9.05
Polar C-term K 352 - s8s9 E 135 N.s8s9.05
Hydrophobic C-term K 352 - s8s9 E 135 N.s8s9.05
Van-der-waals C-term K 352 - s8s9 E 135 N.s8s9.05
Polar ICL2 R 163 34x55 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 R 163 34x55 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 R 163 34x55 s8s9 E 135 N.s8s9.05
Hydrophobic C-term K 352 - s8s9 G 133 N.s8s9.03
Van-der-waals C-term K 352 - s8s9 G 133 N.s8s9.03
Polar ICL1 K 83 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 K 83 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 83 12x49 s20c Y 404 C.s20c.14
Polar C-term T 353 - s8s9 G 133 N.s8s9.03
Hydrophobic C-term T 353 - s8s9 G 133 N.s8s9.03
Van-der-waals C-term T 353 - s8s9 G 133 N.s8s9.03
Hydrophobic C-term V 355 - S16 Y 250 C.S16.03
Van-der-waals C-term V 355 - S16 Y 250 C.S16.03
Polar C-term T 353 - s8s9 E 135 N.s8s9.05
Hydrophobic C-term T 353 - s8s9 E 135 N.s8s9.05
Van-der-waals C-term T 353 - s8s9 E 135 N.s8s9.05
Hydrophobic TM6 T 259 6x26 S6 F 76 N.S6.01
Hydrophobic TM2 L 88 2x39 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 L 88 2x39 s5s6 E 67 N.s5s6.03
Ionic C-term D 342 - s9s10 K 161 N.s9s10.12
Polar C-term D 342 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term D 342 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term D 342 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term S 348 - s8s9 A 140 N.s8s9.10
Van-der-waals C-term S 348 - s8s9 A 140 N.s8s9.10
Polar ICL1 K 82 12x48 s20c Y 404 C.s20c.14
Hydrophobic ICL1 K 82 12x48 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 82 12x48 s20c Y 404 C.s20c.14
Hydrophobic TM5 I 246 5x65 s5s6 L 69 N.s5s6.05
Hydrophobic C-term E 346 - s20c D 406 C.s20c.16
Van-der-waals C-term E 346 - s20c D 406 C.s20c.16
Hydrophobic TM5 V 249 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 V 154 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 V 154 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic H8 R 327 8x48 s5s6 G 73 N.s5s6.09
Van-der-waals H8 R 327 8x48 s5s6 G 73 N.s5s6.09
Polar C-term S 348 - s20c Y 404 C.s20c.14
Hydrophobic C-term S 348 - s20c Y 404 C.s20c.14
Van-der-waals C-term S 348 - s20c Y 404 C.s20c.14
Polar C-term T 353 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term T 353 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term T 353 - s17s18 R 286 C.s17s18.11
Polar C-term A 350 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term A 350 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term A 350 - s17s18 R 286 C.s17s18.11
Polar TM3 V 155 3x54 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 V 155 3x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 V 249 5x68 S6 F 76 N.S6.01
Hydrophobic TM3 V 155 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 V 155 3x54 s5s6 L 72 N.s5s6.08
Polar C-term K 352 - s17s18 E 284 C.s17s18.09
Hydrophobic TM5 V 242 5x61 s5s6 L 72 N.s5s6.08
Polar C-term L 347 - s20c C 409 C.s20c.19
Hydrophobic C-term L 347 - s20c C 409 C.s20c.19
Van-der-waals C-term L 347 - s20c C 409 C.s20c.19
Hydrophobic TM6 V 266 6x33 s5s6 L 72 N.s5s6.08