Beta-arrestin-2 - OX1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OX1 72.9
Beta-arrestin-2 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 G 249 - s15s16 L 244 C.s15s16.02
Hydrophobic ICL2 F 154 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 F 154 34x53 s5s6 R 66 N.s5s6.02
Polar ICL3 G 249 - S6 K 78 N.S6.03
Hydrophobic ICL3 G 249 - S6 K 78 N.S6.03
Van-der-waals ICL3 G 249 - S6 K 78 N.S6.03
Hydrophobic ICL3 T 251 - S6 K 78 N.S6.03
Hydrophobic TM5 I 247 5x70 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 247 5x70 s15s16 F 245 C.s15s16.03
Hydrophobic C-term L 417 - S16 A 248 C.S16.01
Polar ICL2 P 151 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 151 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 151 34x50 S5 Y 64 N.S5.12
Hydrophobic TM5 L 242 5x65 S6 F 76 N.S6.01
Polar TM6 Q 289 6x26 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 Q 289 6x26 s5s6 S 75 N.s5s6.11
Ionic C-term E 413 - s17s18 K 285 C.s17s18.10
Polar C-term E 413 - s17s18 K 285 C.s17s18.10
Hydrophobic C-term E 413 - s17s18 K 285 C.s17s18.10
Van-der-waals C-term E 413 - s17s18 K 285 C.s17s18.10
Hydrophobic TM6 R 293 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 R 293 6x30 S6 F 76 N.S6.01
Hydrophobic ICL3 R 281 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 R 281 - s9s10 L 155 N.s9s10.03
Hydrophobic TM3 I 148 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 247 5x70 S6 K 78 N.S6.03
Hydrophobic ICL3 E 275 - S6 F 81 N.S6.06
Van-der-waals ICL3 E 275 - S6 F 81 N.S6.06
Hydrophobic TM3 A 147 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 A 147 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic C-term V 415 - S16 K 251 C.S16.04
Van-der-waals C-term V 415 - S16 K 251 C.S16.04
Hydrophobic ICL2 L 152 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 152 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 M 299 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 299 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic H8 F 365 8x50 s5s6 V 71 N.s5s6.07
Polar C-term T 418 - S16 Q 249 C.S16.02
Hydrophobic TM6 R 293 6x30 s15s16 F 245 C.s15s16.03
Hydrophobic C-term V 415 - S16 C 252 C.S16.05
Van-der-waals C-term V 415 - S16 C 252 C.S16.05
Ionic TM3 D 143 3x49 s5s6 R 66 N.s5s6.02
Polar TM3 D 143 3x49 s5s6 R 66 N.s5s6.02
Polar TM6 Q 289 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 Q 289 6x26 S6 R 77 N.S6.02
Polar C-term S 419 - S16 Q 249 C.S16.02
Van-der-waals C-term S 419 - S16 Q 249 C.S16.02
Hydrophobic ICL3 Q 277 - S6 A 83 N.S6.08
Van-der-waals ICL3 Q 277 - S6 A 83 N.S6.08
Polar TM4 R 159 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 R 159 4x40 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 R 159 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic C-term L 417 - S16 Y 250 C.S16.03
Van-der-waals C-term L 417 - S16 Y 250 C.S16.03
Polar C-term T 421 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term T 421 - s15s16 T 247 C.s15s16.05
Ionic H8 K 364 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 364 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 A 147 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 147 3x53 s5s6 L 69 N.s5s6.05
Polar TM6 T 296 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 296 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 296 6x33 s5s6 L 72 N.s5s6.08
Polar C-term E 413 - S16 Q 256 C.S16.09
Hydrophobic C-term E 413 - S16 Q 256 C.S16.09
Van-der-waals C-term E 413 - S16 Q 256 C.S16.09
Hydrophobic TM3 R 144 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 144 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 296 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 T 296 6x33 s5s6 L 74 N.s5s6.10
Polar C-term V 416 - S16 K 251 C.S16.04
Polar ICL3 Q 277 - S6 I 82 N.S6.07
Hydrophobic ICL3 Q 277 - S6 I 82 N.S6.07
Van-der-waals ICL3 Q 277 - S6 I 82 N.S6.07
Polar ICL2 L 152 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 152 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 152 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 152 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 152 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 I 148 3x54 S6 F 76 N.S6.01
Polar ICL2 L 152 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 152 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 152 34x51 S16 Y 250 C.S16.03
Ionic ICL3 R 281 - s9s10 E 156 N.s9s10.07
Polar ICL3 R 281 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 281 - s9s10 E 156 N.s9s10.07
Hydrophobic C-term V 415 - s17s18 K 285 C.s17s18.10
Hydrophobic ICL2 K 155 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 K 155 - s17s18 R 286 C.s17s18.11
Hydrophobic TM2 T 79 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 P 248 5x71 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 P 248 5x71 s15s16 F 245 C.s15s16.03
Polar C-term T 418 - S16 K 251 C.S16.04
Hydrophobic C-term T 418 - S16 K 251 C.S16.04
Van-der-waals C-term T 418 - S16 K 251 C.S16.04
Hydrophobic ICL3 E 275 - s7s8 P 121 N.s7s8.03
Van-der-waals ICL3 E 275 - s7s8 P 121 N.s7s8.03
Hydrophobic C-term S 412 - s17s18 E 284 C.s17s18.09
Hydrophobic TM3 I 148 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 148 3x54 s5s6 L 74 N.s5s6.10
Ionic C-term K 410 - s17s18 E 284 C.s17s18.09
Polar C-term K 410 - s17s18 E 284 C.s17s18.09
Hydrophobic C-term K 410 - s17s18 E 284 C.s17s18.09
Van-der-waals C-term K 410 - s17s18 E 284 C.s17s18.09
Hydrophobic C-term V 420 - S16 A 248 C.S16.01
Polar ICL2 S 156 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 S 156 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 S 156 - s5s6 R 66 N.s5s6.02
Hydrophobic TM3 I 148 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 148 3x54 s5s6 L 69 N.s5s6.05
Polar TM4 T 157 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 T 157 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 157 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic C-term V 415 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term V 415 - s17s18 R 286 C.s17s18.11
Polar ICL2 F 154 34x53 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 F 154 34x53 s17s18 R 286 C.s17s18.11
Hydrophobic ICL3 T 251 - S6 D 79 N.S6.04
Van-der-waals ICL3 T 251 - S6 D 79 N.S6.04
Hydrophobic ICL3 L 254 - s7s8 N 123 N.s7s8.05
Van-der-waals ICL3 L 254 - s7s8 N 123 N.s7s8.05
Hydrophobic TM5 L 242 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 242 5x65 s5s6 L 74 N.s5s6.10
Polar H8 S 362 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 362 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 S 362 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 H 76 12x49 s20c Q 407 C.s20c.17
Van-der-waals ICL1 H 76 12x49 s20c Q 407 C.s20c.17
Hydrophobic ICL2 L 152 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 152 34x51 S16 A 248 C.S16.01
Hydrophobic TM6 R 293 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 R 293 6x30 s5s6 L 74 N.s5s6.10
Polar ICL3 T 250 - S6 K 78 N.S6.03
Hydrophobic ICL3 T 250 - S6 K 78 N.S6.03
Van-der-waals ICL3 T 250 - S6 K 78 N.S6.03
Polar ICL3 Q 277 - S6 T 84 N.S6.09
Van-der-waals ICL3 Q 277 - S6 T 84 N.S6.09